Cardiomyocyte Foxp1-Specific Deletion Promotes Post-injury Heart Regeneration via Targeting Usp20-HIF1-Hand1 Signaling Pathway.
Wang Y, Wang X, Fang J, Chen X, Xu T, Zhuang T, Peng S, Bao W, Wu W, Lu Y, Wang H, Tomlinson B, Chan P, Zhuang S, Zhang Q, Zhang L, Liu Z, Pi J, Zhang Y, Liu J.
Wang Y, et al.
Adv Sci (Weinh). 2025 Mar;12(12):e2412124. doi: 10.1002/advs.202412124. Epub 2025 Feb 3.
Adv Sci (Weinh). 2025.
PMID: 39899693
Free PMC article.
The adult mammalian heart has limited regenerative capacity to replace lost tissue after a major injury. ...Thus, Foxp1 regulates HIF1alpha and downstream heart and neural crest derivatives expressed 1 (Hand1) to control the cardiomyocyte proliferation …
The adult mammalian heart has limited regenerative capacity to replace lost tissue after a major injury. ...Thus, Foxp1 regula …