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2019 2
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Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.
Noguchi YT, Nakamura M, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada SI. Noguchi YT, et al. Development. 2019 Feb 20;146(4):dev163618. doi: 10.1242/dev.163618. Development. 2019. PMID: 30745427 Free article.
The undifferentiated state of muscle stem (satellite) cells (MuSCs) is maintained by the canonical Notch pathway. Although three bHLH transcriptional factors, Hey1, HeyL and Hes1, are considered to be potential effectors of the Notch pathway exerting anti-myogenic e …
The undifferentiated state of muscle stem (satellite) cells (MuSCs) is maintained by the canonical Notch pathway. Although three bHLH …
Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.
Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada SI. Fukuda S, et al. Elife. 2019 Sep 23;8:e48284. doi: 10.7554/eLife.48284. Elife. 2019. PMID: 31545169 Free PMC article.
Mechanistically, MuSCs in overloaded muscle sustain the expression of Heyl, a Notch effector gene, to suppress MyoD expression, which allows effective MuSC proliferation on myofibers and beneath the basal lamina. ...Our results show that sustained HeyL expres …
Mechanistically, MuSCs in overloaded muscle sustain the expression of Heyl, a Notch effector gene, to suppress MyoD expression …
[Molecular regulation of muscle stem cells by 'quiescence genes'].
Fukada S. Fukada S. Yakugaku Zasshi. 2011;131(9):1329-32. doi: 10.1248/yakushi.131.1329. Yakugaku Zasshi. 2011. PMID: 21881307 Free article. Review. Japanese.
Skeletal muscle has great regenerative potential that depends on muscle stem cells, called satellite cells. In uninjured muscle, satellite cells reside beneath the basal lamina and are maintained in quiescent and undifferentiated state. ...In our previ …
Skeletal muscle has great regenerative potential that depends on muscle stem cells, called satellite cells. In uninjure …
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H. Fukada S, et al. Development. 2011 Nov;138(21):4609-19. doi: 10.1242/dev.067165. Development. 2011. PMID: 21989910 Free PMC article.
Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during postnatal development, and then are maintained in an undifferentiated quiescent state in adult skeletal muscle. ...We show tha …
Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during …
Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State.
Yamaguchi M, Murakami S, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S. Yamaguchi M, et al. PLoS One. 2015 Sep 29;10(9):e0138517. doi: 10.1371/journal.pone.0138517. eCollection 2015. PLoS One. 2015. PMID: 26418810 Free PMC article.
In vitro, Nrf2 had anti-myogenic and anti-proliferative effects on primary myoblasts. In vivo, although Nrf2-knockout mice showed decreased expression of its target genes in muscle stem cells, adult muscle stem cells of Nrf2-knockout mice did not exhibit the …
In vitro, Nrf2 had anti-myogenic and anti-proliferative effects on primary myoblasts. In vivo, although Nrf2-knockout mice showed dec …
Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy.
Jiang C, Wen Y, Kuroda K, Hannon K, Rudnicki MA, Kuang S. Jiang C, et al. Dis Model Mech. 2014 Aug;7(8):997-1004. doi: 10.1242/dmm.015917. Epub 2014 Jun 6. Dis Model Mech. 2014. PMID: 24906372 Free PMC article.
Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles. One pathological feature of DMD is the progressive depletion of satellite cells, leading to the failure of muscle repair. ...Concomitantly, the expression …
Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles. One pathological featu …
Inhibition of myogenesis by Notch: evidence for multiple pathways.
Buas MF, Kabak S, Kadesch T. Buas MF, et al. J Cell Physiol. 2009 Jan;218(1):84-93. doi: 10.1002/jcp.21571. J Cell Physiol. 2009. PMID: 18727102 Free PMC article.
Notch signaling is critical for skeletal muscle development and regeneration, permitting the expansion of progenitor cells by preventing premature differentiation. ...Notch activation led to the robust induction of the transcriptional repressors Hey1 and HeyL …
Notch signaling is critical for skeletal muscle development and regeneration, permitting the expansion of progenitor cells by …
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