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Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.
Noguchi YT, Nakamura M, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada SI. Noguchi YT, et al. Development. 2019 Feb 20;146(4):dev163618. doi: 10.1242/dev.163618. Development. 2019. PMID: 30745427
We found that HeyL forms heterodimeric complexes with Hes1 in living cells. Moreover, our ChIP-seq experiments demonstrated that, compared with HeyL alone, the HeyL-Hes1 heterodimer binds with high affinity to specific sites in the chromatin, including the bi …
We found that HeyL forms heterodimeric complexes with Hes1 in living cells. Moreover, our ChIP-seq experiments demonstrated that, com …
Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.
Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada SI. Fukuda S, et al. Elife. 2019 Sep 23;8:e48284. doi: 10.7554/eLife.48284. Elife. 2019. PMID: 31545169 Free PMC article.
In overloaded and regenerating muscle, the generation of new myonuclei depends on muscle satellite cells (MuSCs). ...Our results show that sustained HeyL expression is critical for MuSC proliferation specifically in overloaded muscle, and thus indicate …
In overloaded and regenerating muscle, the generation of new myonuclei depends on muscle satellite cells (MuSCs). ...Our resul …
[Molecular regulation of muscle stem cells by 'quiescence genes'].
Fukada S. Fukada S. Yakugaku Zasshi. 2011;131(9):1329-32. doi: 10.1248/yakushi.131.1329. Yakugaku Zasshi. 2011. PMID: 21881307 Free article. Review. Japanese.
Skeletal muscle has great regenerative potential that depends on muscle stem cells, called satellite cells. ...In our previous study, we developed a novel monoclonal antibody that specifically recognized muscle satellite cells in skeletal mus
Skeletal muscle has great regenerative potential that depends on muscle stem cells, called satellite cells. ...In our p
Implication of satellite cell behaviors in capillary growth via VEGF expression-independent mechanism in response to mechanical loading in HeyL-null mice.
Ato S, Fukada SI, Kokubo H, Ogasawara R. Ato S, et al. Am J Physiol Cell Physiol. 2022 Feb 1;322(2):C275-C282. doi: 10.1152/ajpcell.00343.2021. Epub 2022 Jan 12. Am J Physiol Cell Physiol. 2022. PMID: 35020502
However, the relevance among myonuclei number, capillary supply, and angiogenesis factor is not demonstrated. The Notch effector HeyL is specifically expressed in SCs in the skeletal muscle and is crucial for SC proliferation by inhibiting MyoD in overload-in …
However, the relevance among myonuclei number, capillary supply, and angiogenesis factor is not demonstrated. The Notch effector HeyL
TMEM8C-mediated fusion is regionalized and regulated by NOTCH signalling during foetal myogenesis.
Esteves de Lima J, Blavet C, Bonnin MA, Hirsinger E, Havis E, Relaix F, Duprez D. Esteves de Lima J, et al. Development. 2022 Jan 15;149(2):dev199928. doi: 10.1242/dev.199928. Epub 2022 Jan 25. Development. 2022. PMID: 35005776
We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C+ fusion-competent myocytes. NOTCH function in myoblast fusion had not been addressed so far. We analysed the consequences of NOTCH inh …
We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C+ …
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H. Fukada S, et al. Development. 2011 Nov;138(21):4609-19. doi: 10.1242/dev.067165. Development. 2011. PMID: 21989910 Free PMC article.
Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during postnatal development, and then are maintained in an undifferentiated quiescent state in adult skeletal muscle. This state is …
Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during …
Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy.
Jiang C, Wen Y, Kuroda K, Hannon K, Rudnicki MA, Kuang S. Jiang C, et al. Dis Model Mech. 2014 Aug;7(8):997-1004. doi: 10.1242/dmm.015917. Epub 2014 Jun 6. Dis Model Mech. 2014. PMID: 24906372 Free PMC article.
Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles. ...Concomitantly …
Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adult …
Inhibition of myogenesis by Notch: evidence for multiple pathways.
Buas MF, Kabak S, Kadesch T. Buas MF, et al. J Cell Physiol. 2009 Jan;218(1):84-93. doi: 10.1002/jcp.21571. J Cell Physiol. 2009. PMID: 18727102 Free PMC article.
Notch signaling is critical for skeletal muscle development and regeneration, permitting the expansion of progenitor cells by preventing premature differentiation. ...Notch activation led to the robust induction of the transcriptional repressors Hey1 and HeyL
Notch signaling is critical for skeletal muscle development and regeneration, permitting the expansion of progenitor cells by …
Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State.
Yamaguchi M, Murakami S, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S. Yamaguchi M, et al. PLoS One. 2015 Sep 29;10(9):e0138517. doi: 10.1371/journal.pone.0138517. eCollection 2015. PLoS One. 2015. PMID: 26418810 Free PMC article.
In vitro, Nrf2 had anti-myogenic and anti-proliferative effects on primary myoblasts. In vivo, although Nrf2-knockout mice showed decreased expression of its target genes in muscle stem cells, adult muscle stem cells of Nrf2-knockout mice did not exhibit the …
In vitro, Nrf2 had anti-myogenic and anti-proliferative effects on primary myoblasts. In vivo, although Nrf2-knockout mice showed dec …