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Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.
Noguchi YT, Nakamura M, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada SI. Noguchi YT, et al. Development. 2019 Feb 20;146(4):dev163618. doi: 10.1242/dev.163618. Development. 2019. PMID: 30745427
The undifferentiated state of muscle stem (satellite) cells (MuSCs) is maintained by the canonical Notch pathway. Although three bHLH transcriptional factors, Hey1, HeyL and Hes1, are considered to be potential effectors of the Notch pathway exerting anti-myogenic e …
The undifferentiated state of muscle stem (satellite) cells (MuSCs) is maintained by the canonical Notch pathway. Although three bHLH …
Decreased number of satellite cells-derived myonuclei in both fast- and slow-twitch muscles in HeyL-KO mice during voluntary running exercise.
Iwamori K, Kubota M, Zhang L, Kodama K, Kubo A, Kokubo H, Akimoto T, Fukada SI. Iwamori K, et al. Skelet Muscle. 2024 Oct 24;14(1):25. doi: 10.1186/s13395-024-00357-z. Skelet Muscle. 2024. PMID: 39449015 Free PMC article.
METHODS: We used a voluntary wheel running model and HeyL-knockout mice to investigate the impact of HeyL deficiency on MuSC-derived myonuclei, MuSC behavior, muscle weight, myofiber size, and myofiber type in the running mice. ...The frequency of Type IIb my …
METHODS: We used a voluntary wheel running model and HeyL-knockout mice to investigate the impact of HeyL deficiency on MuSC-d …
Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.
Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada SI. Fukuda S, et al. Elife. 2019 Sep 23;8:e48284. doi: 10.7554/eLife.48284. Elife. 2019. PMID: 31545169 Free PMC article.
Mechanistically, MuSCs in overloaded muscle sustain the expression of Heyl, a Notch effector gene, to suppress MyoD expression, which allows effective MuSC proliferation on myofibers and beneath the basal lamina. ...Our results show that sustained HeyL expres …
Mechanistically, MuSCs in overloaded muscle sustain the expression of Heyl, a Notch effector gene, to suppress MyoD expression …
Implication of satellite cell behaviors in capillary growth via VEGF expression-independent mechanism in response to mechanical loading in HeyL-null mice.
Ato S, Fukada SI, Kokubo H, Ogasawara R. Ato S, et al. Am J Physiol Cell Physiol. 2022 Feb 1;322(2):C275-C282. doi: 10.1152/ajpcell.00343.2021. Epub 2022 Jan 12. Am J Physiol Cell Physiol. 2022. PMID: 35020502 Free article.
However, the relevance among myonuclei number, capillary supply, and angiogenesis factor is not demonstrated. The Notch effector HeyL is specifically expressed in SCs in the skeletal muscle and is crucial for SC proliferation by inhibiting MyoD in overload-in …
However, the relevance among myonuclei number, capillary supply, and angiogenesis factor is not demonstrated. The Notch effector HeyL …
TMEM8C-mediated fusion is regionalized and regulated by NOTCH signalling during foetal myogenesis.
Esteves de Lima J, Blavet C, Bonnin MA, Hirsinger E, Havis E, Relaix F, Duprez D. Esteves de Lima J, et al. Development. 2022 Jan 15;149(2):dev199928. doi: 10.1242/dev.199928. Epub 2022 Jan 25. Development. 2022. PMID: 35005776 Free article.
We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C+ fusion-competent myocytes. NOTCH function in myoblast fusion had not been addressed so far. We analysed the consequences of NOTCH inh …
We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C+ …
[Molecular regulation of muscle stem cells by 'quiescence genes'].
Fukada S. Fukada S. Yakugaku Zasshi. 2011;131(9):1329-32. doi: 10.1248/yakushi.131.1329. Yakugaku Zasshi. 2011. PMID: 21881307 Free article. Review. Japanese.
Skeletal muscle has great regenerative potential that depends on muscle stem cells, called satellite cells. ...In our previous study, we developed a novel monoclonal antibody that specifically recognized muscle satellite cells in skeletal mus …
Skeletal muscle has great regenerative potential that depends on muscle stem cells, called satellite cells. ...In our p …
Epigenetics of Genes Displaying High and Preferential Expression in Myoblasts.
Ehrlich KC, Lacey M, Pradhan S, Ehrlich M. Ehrlich KC, et al. Epigenomes. 2026 Mar 13;10(1):20. doi: 10.3390/epigenomes10010020. Epigenomes. 2026. PMID: 41892369 Free PMC article.
Myoblast hypermethylated DMRs were also associated with almost half of the myoblast-preferential genes. ...Myoblast hypermethylated DMRs may also downmodulate expression in myoblasts to avoid yet higher RNA levels found in adult or fetal skeletal …
Myoblast hypermethylated DMRs were also associated with almost half of the myoblast-preferential genes. ...Myoblast hyp …
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H. Fukada S, et al. Development. 2011 Nov;138(21):4609-19. doi: 10.1242/dev.067165. Development. 2011. PMID: 21989910 Free PMC article.
Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during postnatal development, and then are maintained in an undifferentiated quiescent state in adult skeletal muscle. This state is …
Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during …
Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy.
Jiang C, Wen Y, Kuroda K, Hannon K, Rudnicki MA, Kuang S. Jiang C, et al. Dis Model Mech. 2014 Aug;7(8):997-1004. doi: 10.1242/dmm.015917. Epub 2014 Jun 6. Dis Model Mech. 2014. PMID: 24906372 Free PMC article.
Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles. ...Concomitantly …
Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adult …
Inhibition of myogenesis by Notch: evidence for multiple pathways.
Buas MF, Kabak S, Kadesch T. Buas MF, et al. J Cell Physiol. 2009 Jan;218(1):84-93. doi: 10.1002/jcp.21571. J Cell Physiol. 2009. PMID: 18727102 Free PMC article.
Notch signaling is critical for skeletal muscle development and regeneration, permitting the expansion of progenitor cells by preventing premature differentiation. ...Notch activation led to the robust induction of the transcriptional repressors Hey1 and HeyL …
Notch signaling is critical for skeletal muscle development and regeneration, permitting the expansion of progenitor cells by …
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