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Frequency of Coronary Microvascular Dysfunction and Diffuse Myocardial Fibrosis (Measured by Cardiovascular Magnetic Resonance) in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction.
Löffler AI, Pan JA, Balfour PC Jr, Shaw PW, Yang Y, Nasir M, Auger DA, Epstein FH, Kramer CM, Gan LM, Salerno M. Löffler AI, et al. Am J Cardiol. 2019 Nov 15;124(10):1584-1589. doi: 10.1016/j.amjcard.2019.08.011. Epub 2019 Aug 22. Am J Cardiol. 2019. PMID: 31575425 Free PMC article.
The purpose of this study is to examine the relation between myocardial perfusion reserve (MPR) and diffuse myocardial fibrosis in patients with HFpEF using cardiovascular magnetic resonance. ...T1 mapping was used to assess fibrosis …
The purpose of this study is to examine the relation between myocardial perfusion reserve (MPR) and diffuse myocardial fibr …
CMR-verified diffuse myocardial fibrosis is associated with diastolic dysfunction in HFpEF.
Su MY, Lin LY, Tseng YH, Chang CC, Wu CK, Lin JL, Tseng WY. Su MY, et al. JACC Cardiovasc Imaging. 2014 Oct;7(10):991-7. doi: 10.1016/j.jcmg.2014.04.022. Epub 2014 Sep 17. JACC Cardiovasc Imaging. 2014. PMID: 25240451 Free article.
Extracellular volume fraction (ECV), a measure of diffuse myocardial fibrosis, was quantified from T1 mapping. Systolic and diastolic functions of the LV were assessed by cine CMR. ...Diffuse myocardial fibrosis plays a unique role in the …
Extracellular volume fraction (ECV), a measure of diffuse myocardial fibrosis, was quantified from T1 mapping. S …
Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.
Kanagala P, Cheng ASH, Singh A, Khan JN, Gulsin GS, Patel P, Gupta P, Arnold JR, Squire IB, Ng LL, McCann GP. Kanagala P, et al. JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 2):2291-2301. doi: 10.1016/j.jcmg.2018.11.031. Epub 2019 Feb 13. JACC Cardiovasc Imaging. 2019. PMID: 30772227 Free article.
BACKGROUND: Myocardial fibrosis has been implicated in the pathophysiology of HFpEF. ...Late gadolinium-enhanced (LGE) imaging and T1 mapping to calculate myocardial extracellular volume indexed to body surface area (iECV) were used to as …
BACKGROUND: Myocardial fibrosis has been implicated in the pathophysiology of HFpEF. ...Late gadolinium-enhanced (LGE) …
Fibroblast growth factor 23: a biomarker of fibrosis and prognosis in heart failure with preserved ejection fraction.
Roy C, Lejeune S, Slimani A, de Meester C, Ahn As SA, Rousseau MF, Mihaela A, Ginion A, Ferracin B, Pasquet A, Vancraeynest D, Beauloye C, Vanoverschelde JL, Horman S, Gruson D, Gerber BL, Pouleur AC. Roy C, et al. ESC Heart Fail. 2020 Oct;7(5):2494-2507. doi: 10.1002/ehf2.12816. Epub 2020 Jun 24. ESC Heart Fail. 2020. PMID: 32578967 Free PMC article.
However, data about FGF-23 in HF and preserved ejection fraction (HFpEF) remain limited. The aim of this study was to assess the association between FGF-23 levels, clinical and imaging characteristics, particularly diffuse myocardial fibrosis, and prognosis i …
However, data about FGF-23 in HF and preserved ejection fraction (HFpEF) remain limited. The aim of this study was to assess the asso …
Diagnostic and Prognostic Value of CMR T(1)-Mapping in Patients With Heart Failure and Preserved Ejection Fraction.
Rommel KP, Lücke C, Lurz P. Rommel KP, et al. Rev Esp Cardiol (Engl Ed). 2017 Oct;70(10):848-855. doi: 10.1016/j.rec.2017.02.018. Epub 2017 Mar 15. Rev Esp Cardiol (Engl Ed). 2017. PMID: 28314659 Review. English, Spanish.
Diastolic dysfunction is a diagnostic and pathophysiological cornerstone in HFpEF and is believed to be caused by systemic inflammation with the development of interstitial myocardial fibrosis and myocardial stiffening. Cardiac magnetic resonance (CMR) …
Diastolic dysfunction is a diagnostic and pathophysiological cornerstone in HFpEF and is believed to be caused by systemic inflammati …
Diffuse right ventricular fibrosis in heart failure with preserved ejection fraction and pulmonary hypertension.
Patel RB, Li E, Benefield BC, Swat SA, Polsinelli VB, Carr JC, Shah SJ, Markl M, Collins JD, Freed BH. Patel RB, et al. ESC Heart Fail. 2020 Feb;7(1):253-263. doi: 10.1002/ehf2.12565. Epub 2020 Jan 5. ESC Heart Fail. 2020. PMID: 31903694 Free PMC article.
T1 mapping was performed using high-resolution modified look-locker inversion recovery with a 1 1 mm(2) in-plane resolution. ...In PH-HFpEF, diffuse RV fibrosis may occur out of proportion to the degree of RV afterload....
T1 mapping was performed using high-resolution modified look-locker inversion recovery with a 1 1 mm(2) in-plane resolution. . …
CMR Tissue Characterization in Patients with HFmrEF.
Doeblin P, Hashemi D, Tanacli R, Lapinskas T, Gebker R, Stehning C, Motzkus LA, Blum M, Tahirovic E, Dordevic A, Kraft R, Zamani SM, Pieske B, Edelmann F, Düngen HD, Kelle S. Doeblin P, et al. J Clin Med. 2019 Nov 5;8(11):1877. doi: 10.3390/jcm8111877. J Clin Med. 2019. PMID: 31694263 Free PMC article.
T1 and T2 relaxation time mapping was performed and the extracellular volume (ECV) was calculated. ...GLS (-15.7 2.1) and GCS (-19.9 4.1) were moderately reduced in HFmrEF, resembling systolic dysfunction. Native T1 relaxation times were elevated in HFmrEF (1 …
T1 and T2 relaxation time mapping was performed and the extracellular volume (ECV) was calculated. ...GLS (-15.7 2.1) and GCS …
Feature Tracking of Global Longitudinal Strain by Using Cardiovascular MRI Improves Risk Stratification in Heart Failure with Preserved Ejection Fraction.
Kammerlander AA, Donà C, Nitsche C, Koschutnik M, Schönbauer R, Duca F, Zotter-Tufaro C, Binder C, Aschauer S, Beitzke D, Loewe C, Hengstenberg C, Bonderman D, Mascherbauer J. Kammerlander AA, et al. Radiology. 2020 Aug;296(2):290-298. doi: 10.1148/radiol.2020200195. Epub 2020 Jun 2. Radiology. 2020. PMID: 32484413
Feature-tracking cardiovascular MRI also allows for strain analysis; however, to the knowledge of the authors, little is known about its prognostic value and whether it reflects severity of diffuse fibrosis, as assessed by cardiovascular MRI T1 mapping. Purpo …
Feature-tracking cardiovascular MRI also allows for strain analysis; however, to the knowledge of the authors, little is known about its pro …
Cardiac MRI for the prognostication of heart failure with preserved ejection fraction: A systematic review and meta-analysis.
Assadi H, Jones R, Swift AJ, Al-Mohammad A, Garg P. Assadi H, et al. Magn Reson Imaging. 2021 Feb;76:116-122. doi: 10.1016/j.mri.2020.11.011. Epub 2020 Nov 19. Magn Reson Imaging. 2021. PMID: 33221422 Free PMC article.
The main cardiac MRI methods that demonstrated association to prognosis in HFpEF included late gadolinium enhancement (LGE) assessment of scar (n = 3), tissue characterisation with T1-mapping (n = 4), myocardial ischaemia (n = 1) and right ventricular …
The main cardiac MRI methods that demonstrated association to prognosis in HFpEF included late gadolinium enhancement (LGE) assessmen …
Native T1 time of right ventricular insertion points by cardiac magnetic resonance: relation with invasive haemodynamics and outcome in heart failure with preserved ejection fraction.
Nitsche C, Kammerlander AA, Binder C, Duca F, Aschauer S, Koschutnik M, Snidat A, Beitzke D, Loewe C, Bonderman D, Hengstenberg C, Mascherbauer J. Nitsche C, et al. Eur Heart J Cardiovasc Imaging. 2020 Jun 1;21(6):683-691. doi: 10.1093/ehjci/jez221. Eur Heart J Cardiovasc Imaging. 2020. PMID: 31495874
AIMS: Increased afterload to the right ventricle (RV) has been shown to induce myocardial fibrosis at the RV insertion points (RVIPs). Such changes can be discrete but potentially detected by cardiac magnetic resonance (CMR) T1-mapping. ...CONCLUSION: …
AIMS: Increased afterload to the right ventricle (RV) has been shown to induce myocardial fibrosis at the RV insertion points …
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