Abstract
Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Analysis of Variance
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Biomarkers / blood
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Birth Weight
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Bone Density
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Bone Resorption / blood*
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Case-Control Studies
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Collagen / analysis
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Collagen Type I
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Diabetes Mellitus, Type 1 / blood*
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Female
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Fetal Blood / metabolism
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Fetal Diseases / blood*
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Humans
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Infant, Newborn
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Peptide Fragments / blood
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Peptides / analysis
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Pregnancy
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Pregnancy in Diabetics / blood*
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Procollagen / blood
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Prospective Studies
Substances
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Biomarkers
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Collagen Type I
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Peptide Fragments
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Peptides
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Procollagen
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collagen type I trimeric cross-linked peptide
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procollagen type I carboxy terminal peptide
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Collagen