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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 1
2004 3
2005 4
2007 3
2008 4
2009 7
2010 4
2011 8
2012 4
2013 7
2014 9
2015 11
2016 7
2017 10
2018 10
2019 22
2020 19
2021 13
2022 7
2023 2
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2025 44
2026 2

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200 results

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Page 1
Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-kappaB/HIF-1alpha Pathway by Bioinformatics and Experimental Validation.
Li J, Dan W, Zhang C, Liu N, Wang Y, Liu J, Zhang S. Li J, et al. Drug Des Devel Ther. 2024 Jul 9;18:2847-2868. doi: 10.2147/DDDT.S436359. eCollection 2024. Drug Des Devel Ther. 2024. PMID: 39006190 Free PMC article.
PATIENTS AND METHODS: We systematically screened potential targets and relevant pathways affected by berberine for UC treatment from comprehensive databases, including GeneCards, DisGeNET, and GEO. ...The predictions were validated using both a DSS-induced UC mouse model a …
PATIENTS AND METHODS: We systematically screened potential targets and relevant pathways affected by berberine for UC treatment from …
HIF1α and metabolic reprogramming in inflammation.
Corcoran SE, O'Neill LA. Corcoran SE, et al. J Clin Invest. 2016 Oct 3;126(10):3699-3707. doi: 10.1172/JCI84431. Epub 2016 Aug 29. J Clin Invest. 2016. PMID: 27571407 Free PMC article. Review.
HIF1alpha is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. ...
HIF1alpha is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell e …
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer.
Bao MH, Wong CC. Bao MH, et al. Cells. 2021 Jul 6;10(7):1715. doi: 10.3390/cells10071715. Cells. 2021. PMID: 34359884 Free PMC article. Review.
In this review, we particularly focus on the roles of hypoxia-inducible factor (HIF)-mediated metabolic reprogramming in drug resistance in HCC. Combination therapies targeting hypoxia-induced metabolic enzymes to overcome drug resistance will also be summarized. ...
In this review, we particularly focus on the roles of hypoxia-inducible factor (HIF)-mediated metabolic reprogramming in drug resista …
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Luo W, et al. Cell. 2011 May 27;145(5):732-44. doi: 10.1016/j.cell.2011.03.054. Cell. 2011. PMID: 21620138 Free PMC article.
PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes to tumorigenesis by mechanisms that are not explained by its known biochemical activity. We show that PKM2 gene transcription is activated by hypoxia-inducible factor 1 (HIF-1). PKM2 inter …
PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes to tumorigenesis by mechanisms that are not explained by its k …
Hypoxia and the endometrium: An indispensable role for HIF-1α as therapeutic strategies.
Dai W, Guo R, Na X, Jiang S, Liang J, Guo C, Fang Y, Na Z, Li D. Dai W, et al. Redox Biol. 2024 Jul;73:103205. doi: 10.1016/j.redox.2024.103205. Epub 2024 May 21. Redox Biol. 2024. PMID: 38815332 Free PMC article. Review.
Nonetheless, additional efforts are required to elucidate the regulatory network of endometrial HIF-1alpha and promote the applications of HIF-1alpha-centered strategies in the human endometrium. Here, we summarize the role of the HIF-1alpha-mediated pathway in endo …
Nonetheless, additional efforts are required to elucidate the regulatory network of endometrial HIF-1alpha and promote the applicatio …
D-mannose suppresses macrophage IL-1β production.
Torretta S, Scagliola A, Ricci L, Mainini F, Di Marco S, Cuccovillo I, Kajaste-Rudnitski A, Sumpton D, Ryan KM, Cardaci S. Torretta S, et al. Nat Commun. 2020 Dec 11;11(1):6343. doi: 10.1038/s41467-020-20164-6. Nat Commun. 2020. PMID: 33311467 Free PMC article.
Astragali radix - Curcumae rhizoma herb pair suppresses hepatocellular carcinoma through EGFR/AKT/mTOR pathway and induces lipid peroxidation-related ferroptosis via HIF-1alpha/HO-1/GPX4 axis.
Wang C, Shi CH, Bai HY, Lu J, Hu HT, Sun YM, Gao H, An H, Lu JH, Zhao HJ, Zhu ZH. Wang C, et al. J Ethnopharmacol. 2025 May 28;348:119912. doi: 10.1016/j.jep.2025.119912. Epub 2025 Apr 30. J Ethnopharmacol. 2025. PMID: 40316156
METHODS: The efficacy and safety of ACHP against HCC in vivo were evaluated by tumor volume, organ index, H&E staining, hepatic and renal factors. The serum metabolites of ACHP were identified by UPLC-Q-TOF-MS/MS. The key targets and potential mechanisms of ACHP agains …
METHODS: The efficacy and safety of ACHP against HCC in vivo were evaluated by tumor volume, organ index, H&E staining, hepatic and rena …
Genipin ameliorates diabetic retinopathy via the HIF-1alpha and AGEs-RAGE pathways.
Sun K, Chen Y, Zheng S, Wan W, Hu K. Sun K, et al. Phytomedicine. 2024 Jul;129:155596. doi: 10.1016/j.phymed.2024.155596. Epub 2024 Apr 7. Phytomedicine. 2024. PMID: 38626646
The protein expression of the AKT/ PI3K/ HIF-1alpha and AGEs/ RAGE pathways was also examined. RESULTS: Approximately 14 types of TCM, and nearly 300 active ingredients, including genipin, were identified. ...Genipin protects cells and tissues from high glucose levels by r …
The protein expression of the AKT/ PI3K/ HIF-1alpha and AGEs/ RAGE pathways was also examined. RESULTS: Approximately 14 types of TCM …
XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway.
Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH. Chen X, et al. Nature. 2014 Apr 3;508(7494):103-107. doi: 10.1038/nature13119. Epub 2014 Mar 23. Nature. 2014. PMID: 24670641 Free PMC article.
Cancer cells induce a set of adaptive response pathways to survive in the face of stressors due to inadequate vascularization. One such adaptive pathway is the unfolded protein (UPR) or endoplasmic reticulum (ER) stress response mediated in part by the ER-localized …
Cancer cells induce a set of adaptive response pathways to survive in the face of stressors due to inadequate vascularization. One su …
Neutrophil HIF-1α stabilization is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle.
Willson JA, Arienti S, Sadiku P, Reyes L, Coelho P, Morrison T, Rinaldi G, Dockrell DH, Whyte MKB, Walmsley SR. Willson JA, et al. Blood. 2022 Jan 13;139(2):281-286. doi: 10.1182/blood.2021011010. Blood. 2022. PMID: 34411229 Free PMC article.
This is needed for the stabilization of a high level of the critical hypoxic response factor and pro-survival protein HIF-1alpha in hypoxia. Further, we demonstrate that neutrophils use the glycerol 3-phosphate pathway as a way of directly regulating mitochondrial f …
This is needed for the stabilization of a high level of the critical hypoxic response factor and pro-survival protein HIF-1alpha in h …
200 results