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107 results

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Page 1
Preclinical Development in Radiopharmaceutical Therapy for Prostate Cancer.
Alati S, Singh R, Pomper MG, Rowe SP, Banerjee SR. Alati S, et al. Semin Nucl Med. 2023 Sep;53(5):663-686. doi: 10.1053/j.semnuclmed.2023.06.007. Epub 2023 Jul 18. Semin Nucl Med. 2023. PMID: 37468417 Review.
Prostate cancer is a leading cause of cancer death in men worldwide. Among the various treatment options, radiopharmaceutical therapy has shown notable success in metastatic, castration-resistant disease. ...Besides PSMA-based radiotherapeutics, other prominent pros …
Prostate cancer is a leading cause of cancer death in men worldwide. Among the various treatment options, radiopharmaceutical …
HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer.
Pudova EA, Kudryavtseva AV, Fedorova MS, Zaretsky AR, Shcherbo DS, Lukyanova EN, Popov AY, Sadritdinova AF, Abramov IS, Kharitonov SL, Krasnov GS, Klimina KM, Koroban NV, Volchenko NN, Nyushko KM, Melnikova NV, Chernichenko MA, Sidorov DV, Alekseev BY, Kiseleva MV, Kaprin AD, Dmitriev AA, Snezhkina AV. Pudova EA, et al. BMC Genomics. 2018 Feb 9;19(Suppl 3):113. doi: 10.1186/s12864-018-4477-4. BMC Genomics. 2018. PMID: 29504907 Free PMC article.
BACKGROUND: Colorectal cancer (CRC) is a common cancer worldwide. The main cause of death in CRC includes tumor progression and metastasis. ...We obtained the set of genes with significant correlation coefficients, which included 21 EMT-related genes and a single gl …
BACKGROUND: Colorectal cancer (CRC) is a common cancer worldwide. The main cause of death in CRC includes tumor progression an …
CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure.
Li T, Gu Y, Xu B, Kuca K, Zhang J, Wu W. Li T, et al. Mol Cancer. 2023 Apr 27;22(1):77. doi: 10.1186/s12943-023-01771-5. Mol Cancer. 2023. PMID: 37106446 Free PMC article.
Furthermore, circZBTB44 upregulated Hexokinase 3 (HK3) expression by binding to IGF2BP3 in RCC cells. HK3 exerted oncogenic effects on RCC cell malignant behaviors and tumor growth. In the co-culture of RCC cells with macrophages, circZBTB44 promoted M2 polarization …
Furthermore, circZBTB44 upregulated Hexokinase 3 (HK3) expression by binding to IGF2BP3 in RCC cells. HK3 exerted oncogenic ef …
Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics?
Mannello F, Gazzanelli G. Mannello F, et al. Breast Cancer Res. 2001;3(4):238-43. doi: 10.1186/bcr302. Epub 2001 May 10. Breast Cancer Res. 2001. PMID: 11434875 Free PMC article. Review.
Since its identification, much information has been obtained about prostate-specific antigen (PSA, or human glandular kallikrein 3 [hK3]), a kallikrein-like serine protease that is the most valuable tumour marker for the screening, diagnosis and management of human prostat …
Since its identification, much information has been obtained about prostate-specific antigen (PSA, or human glandular kallikrein 3 [hK3 …
Dual roles of HK3 in regulating the network between tumor cells and tumor-associated macrophages in neuroblastoma.
Wu X, Mi T, Jin L, Ren C, Wang J, Zhang Z, Liu J, Wang Z, Guo P, He D. Wu X, et al. Cancer Immunol Immunother. 2024 May 7;73(7):122. doi: 10.1007/s00262-024-03702-9. Cancer Immunol Immunother. 2024. PMID: 38714539 Free PMC article.
Targeting tumor-associated macrophages (TAMs) is a strategy for attenuating tumor-promoting states. The crosstalk between cancer cells and TAMs plays a pivotal role in mediating tumor progression in NB. The overexpression of Hexokinase-3 (HK3), a pivotal enzyme in g …
Targeting tumor-associated macrophages (TAMs) is a strategy for attenuating tumor-promoting states. The crosstalk between cancer cell …
HK3 stimulates immune cell infiltration to promote glioma deterioration.
Li S, Li Z, Wang X, Zhong J, Yu D, Chen H, Ma W, Liu L, Ye M, Shen R, Jiang C, Meng X, Cai J. Li S, et al. Cancer Cell Int. 2023 Oct 1;23(1):227. doi: 10.1186/s12935-023-03039-w. Cancer Cell Int. 2023. PMID: 37779195 Free PMC article.
METHODS: In our work, we analyzed the co-expression relationship between glycolytic genes and immune checkpoints based on the transcriptomic data from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) and found the correlation between HK3 express …
METHODS: In our work, we analyzed the co-expression relationship between glycolytic genes and immune checkpoints based on the transcriptomic …
The role of molecular forms of prostate-specific antigen (PSA or hK3) and of human glandular kallikrein 2 (hK2) in the diagnosis and monitoring of prostate cancer and in extra-prostatic disease.
Becker C, Noldus J, Diamandis E, Lilja H. Becker C, et al. Crit Rev Clin Lab Sci. 2001 Oct;38(5):357-99. doi: 10.1080/20014091084236. Crit Rev Clin Lab Sci. 2001. PMID: 11720279 Review.
Prostate-specific antigen (PSA or hK3) is a glandular kallikrein with abundant expression in the prostate that is widely used to detect and monitor prostate cancer (PCa), although the serum level is frequently elevated also in benign and inflammatory prostatic disea …
Prostate-specific antigen (PSA or hK3) is a glandular kallikrein with abundant expression in the prostate that is widely used to dete …
Hexokinase HK3-mediated O-GlcNAcylation of EP300: a key regulator of PD-L1 expression and immune evasion in ccRCC.
Zhang W, Zhao E, Li Z, Liu W, Wang J, Hou W, Zhang N, Yu Y, Li X, You B. Zhang W, et al. Cell Death Dis. 2024 Aug 23;15(8):613. doi: 10.1038/s41419-024-06921-1. Cell Death Dis. 2024. PMID: 39179546 Free PMC article.
Our research identified that the glycolysis-related gene (GRG) HK3 has a unique correlation with PD-L1 expression. HK3 has been identified as a key regulator of O-GlcNAcylation in ccRCC. ...The uridine 5'-diphospho-N-acetylglucosamine (UDP-GlcNAc), which serves as a …
Our research identified that the glycolysis-related gene (GRG) HK3 has a unique correlation with PD-L1 expression. HK3 has bee …
HK3 is correlated with immune infiltrates and predicts response to immunotherapy in non-small cell lung cancer.
Tuo Z, Zheng X, Zong Y, Li J, Zou C, Lv Y, Liu J. Tuo Z, et al. Clin Transl Med. 2020 Jan;10(1):319-330. doi: 10.1002/ctm2.6. Clin Transl Med. 2020. PMID: 32508023 Free PMC article.
According to a recent study, HK3 has a functional role in the treatment of acute promyelocytic leukemia and colorectal cancer. RESULTS: Here, we studied the co-expression relationship between the glycolytic pathway gene and the immune checkpoint gene and found that …
According to a recent study, HK3 has a functional role in the treatment of acute promyelocytic leukemia and colorectal cancer. …
Glioma hexokinase 3 positively correlates with malignancy and macrophage infiltration.
Liang T, Zhou X, Wang Y, Ma W. Liang T, et al. Metab Brain Dis. 2024 Jun;39(5):719-729. doi: 10.1007/s11011-023-01333-0. Epub 2024 Apr 30. Metab Brain Dis. 2024. PMID: 38687460
METHODS: This study comprehensively assessed the expression distribution and immunological effect of HK3 via pan-cancer analysis based on datasets from Genotype Tissue Expression (GTEx), Cancer Cell Line Encyclopedia (CCLE), and The Cancer Genome Atlas …
METHODS: This study comprehensively assessed the expression distribution and immunological effect of HK3 via pan-cancer analys …
107 results