HL‑066088/HL/NHLBI NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
2010	1
2012	2
2013	4
2014	1
2021	0

1

Liver X receptors in lipid metabolism: opportunities for drug discovery.

Hong C, Tontonoz P. Hong C, et al. Nat Rev Drug Discov. 2014 Jun;13(6):433-44. doi: 10.1038/nrd4280. Epub 2014 May 16. Nat Rev Drug Discov. 2014. PMID: 24833295 Review.

2

Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis.

Zhang L, Reue K, Fong LG, Young SG, Tontonoz P. Zhang L, et al. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2541-6. doi: 10.1161/ATVBAHA.112.250571. Epub 2012 Aug 30. Arterioscler Thromb Vasc Biol. 2012. PMID: 22936343 Free PMC article. Review.

3

The nuclear receptor LXRα controls the functional specialization of splenic macrophages.

A-Gonzalez N, Guillen JA, Gallardo G, Diaz M, de la Rosa JV, Hernandez IH, Casanova-Acebes M, Lopez F, Tabraue C, Beceiro S, Hong C, Lara PC, Andujar M, Arai S, Miyazaki T, Li S, Corbi AL, Tontonoz P, Hidalgo A, Castrillo A. A-Gonzalez N, et al. Nat Immunol. 2013 Aug;14(8):831-9. doi: 10.1038/ni.2622. Epub 2013 Jun 16. Nat Immunol. 2013. PMID: 23770640 Free PMC article.

4

IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.

Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P. Scotti E, et al. Mol Cell Biol. 2013 Apr;33(8):1503-14. doi: 10.1128/MCB.01716-12. Epub 2013 Feb 4. Mol Cell Biol. 2013. PMID: 23382078 Free PMC article.

5

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.

Hong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis AJ, Tangirala RK, Tontonoz P. Hong C, et al. J Lipid Res. 2012 Jun;53(6):1126-33. doi: 10.1194/jlr.M022061. Epub 2012 Mar 26. J Lipid Res. 2012. PMID: 22454476 Free PMC article.

6

Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice.

Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P. Chao LC, et al. J Lipid Res. 2013 Mar;54(3):806-15. doi: 10.1194/jlr.M034157. Epub 2013 Jan 3. J Lipid Res. 2013. PMID: 23288947 Free PMC article.

7

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression.

Feig JE, Pineda-Torra I, Sanson M, Bradley MN, Vengrenyuk Y, Bogunovic D, Gautier EL, Rubinstein D, Hong C, Liu J, Wu C, van Rooijen N, Bhardwaj N, Garabedian M, Tontonoz P, Fisher EA. Feig JE, et al. J Clin Invest. 2010 Dec;120(12):4415-24. doi: 10.1172/JCI38911. J Clin Invest. 2010. PMID: 21041949 Free PMC article.

8

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor.

Zhang L, Xu M, Scotti E, Chen ZJ, Tontonoz P. Zhang L, et al. J Lipid Res. 2013 May;54(5):1410-20. doi: 10.1194/jlr.M035774. Epub 2013 Feb 18. J Lipid Res. 2013. PMID: 23419260 Free PMC article.

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