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T-helper type 2-driven inflammation defines major subphenotypes of asthma.
Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. Woodruff PG, et al. Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95. doi: 10.1164/rccm.200903-0392OC. Epub 2009 May 29. Am J Respir Crit Care Med. 2009. PMID: 19483109 Free PMC article. Clinical Trial.
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy JV, Woodruff PG, Harris JM, Arron JR; Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) Study Group. Jia G, et al. J Allergy Clin Immunol. 2012 Sep;130(3):647-654.e10. doi: 10.1016/j.jaci.2012.06.025. Epub 2012 Aug 1. J Allergy Clin Immunol. 2012. PMID: 22857879 Free PMC article.
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.
Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. Woodruff PG, et al. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15858-63. doi: 10.1073/pnas.0707413104. Epub 2007 Sep 26. Proc Natl Acad Sci U S A. 2007. PMID: 17898169 Free PMC article. Clinical Trial.