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HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats.
Arthritis Rheum. 2009.
PMID: 19714651
Free PMC article.
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The role of the unfolded protein response in axial spondyloarthritis.
Smith JA.
Smith JA.
Clin Rheumatol. 2016 Jun;35(6):1425-31. doi: 10.1007/s10067-015-3117-5. Epub 2015 Nov 14.
Clin Rheumatol. 2016.
PMID: 26567900
Review.
Beyond its nominal role in antigen presentation, HLA-B27 displays interesting and possibly unique biochemical characteristics which may contribute to disease pathogenesis. During its biosynthesis in the endoplasmic reticulum (ER), HLA-B27 folds …
Beyond its nominal role in antigen presentation, HLA-B27 displays interesting and possibly unique biochemical character …
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HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats.
DeLay ML, Turner MJ, Klenk EI, Smith JA, Sowders DP, Colbert RA.
DeLay ML, et al.
Arthritis Rheum. 2009 Sep;60(9):2633-43. doi: 10.1002/art.24763.
Arthritis Rheum. 2009.
PMID: 19714651
Free PMC article.
OBJECTIVE: To determine whether HLA-B27 misfolding and the unfolded protein response (UPR) result in cytokine dysregulation and whether this is associated with Th1 and/or Th17 activation in HLA-B27/human beta(2)-microglobuli …
OBJECTIVE: To determine whether HLA-B27 misfolding and the unfolded protein response (UPR) result …
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The enigmatic role of HLA-B*27 in spondyloarthritis pathogenesis.
Navid F, Holt V, Colbert RA.
Navid F, et al.
Semin Immunopathol. 2021 Apr;43(2):235-243. doi: 10.1007/s00281-021-00838-z. Epub 2021 Jan 22.
Semin Immunopathol. 2021.
PMID: 33481054
Review.
Recent studies implicate HLA-B*27 in aberrant bone formation. An unanticipated cell surface interaction between HLA-B*27 and the bone morphogenetic protein pathway receptor subunit ALK2 may augment TGFbeta superfamily signaling pathways, increasing res …
Recent studies implicate HLA-B*27 in aberrant bone formation. An unanticipated cell surface interaction between HLA-B*27 and t …
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