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The Role of HLA-Class I Heavy-Chain Interactions with Killer-Cell Immunoglobulin-Like Receptors in Immune Regulation.
Kollnberger S. Kollnberger S. Crit Rev Immunol. 2016;36(3):269-282. doi: 10.1615/CritRevImmunol.2016017965. Crit Rev Immunol. 2016. PMID: 28008807 Review.
B2m-free class I heavy chains (FHCs) form on cells either as a consequence of the natural turnover of pMHC or, in the case of HLA-F, are expressed without beta2m. Distinct characteristics of certain HLA-class I members, such as HLA-B27 …
B2m-free class I heavy chains (FHCs) form on cells either as a consequence of the natural turnover of pMHC or, in the c …
The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09.
Cauli A, Shaw J, Giles J, Hatano H, Rysnik O, Payeli S, McHugh K, Dessole G, Porru G, Desogus E, Fiedler S, Hölper S, Carette A, Blanco-Gelaz MA, Vacca A, Piga M, Ibba V, Garau P, La Nasa G, López-Larrea C, Mathieu A, Renner C, Bowness P, Kollnberger S. Cauli A, et al. Rheumatology (Oxford). 2013 Nov;52(11):1952-62. doi: 10.1093/rheumatology/ket219. Epub 2013 Jun 26. Rheumatology (Oxford). 2013. PMID: 23804219 Free PMC article.
Thus, the objective of this study was to compare the formation of beta2m-free heavy chain (FHC) including B27 dimers (B272) by HLA-B*27:05 and HLA-B*27:09 and their binding to KIR immunoreceptors. ...Increased proportions of NK and CD4 T …
Thus, the objective of this study was to compare the formation of beta2m-free heavy chain (FHC) including B27 di …
The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis.
Kollnberger S, Bowness P. Kollnberger S, et al. Adv Exp Med Biol. 2009;649:277-85. doi: 10.1007/978-1-4419-0298-6_21. Adv Exp Med Biol. 2009. PMID: 19731637 Review.
HLA-B27 (B27) is strongly associated with spondyloarthopathy. The classical role of B27 is to present peptides from intracellular pathogens as a heterotrimeric complex with beta2 microglobulin for recognition by the T-cell receptor (TCR) of CD8 T-cells …
HLA-B27 (B27) is strongly associated with spondyloarthopathy. The classical role of B27 is to present peptides f …
Therapeutic Antibodies to KIR3DL2 and Other Target Antigens on Cutaneous T-Cell Lymphomas.
Schmitt C, Marie-Cardine A, Bensussan A. Schmitt C, et al. Front Immunol. 2017 Aug 30;8:1010. doi: 10.3389/fimmu.2017.01010. eCollection 2017. Front Immunol. 2017. PMID: 28912774 Free PMC article. Review.
Several ligands have been identified for KIR3DL2. As for other KIRs, binding to HLA class I molecules is essential for NK development by promoting phenomena such as licensing and driving NK cell maturation. For KIR3DL2, this includes binding to HLA-A3 …
Several ligands have been identified for KIR3DL2. As for other KIRs, binding to HLA class I molecules is essential for NK deve …
Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide.
Kollnberger S, Chan A, Sun MY, Chen LY, Wright C, di Gleria K, McMichael A, Bowness P. Kollnberger S, et al. Eur J Immunol. 2007 May;37(5):1313-22. doi: 10.1002/eji.200635997. Eur J Immunol. 2007. PMID: 17407096 Free article.
HLA-B27 can form beta-2 microglobulin (beta2m)-associated heterotrimers (HLA-B27) and beta2m-free homodimers (B27(2)). ...Heterotrimeric complexes containing peptides with charged amino acids at position 8 did not bind to KIR3DL1; however …
HLA-B27 can form beta-2 microglobulin (beta2m)-associated heterotrimers (HLA-B27) and beta2m-free homodim …
The biochemistry and immunology of non-canonical forms of HLA-B27.
Shaw J, Hatano H, Kollnberger S. Shaw J, et al. Mol Immunol. 2014 Jan;57(1):52-8. doi: 10.1016/j.molimm.2013.05.243. Epub 2013 Aug 1. Mol Immunol. 2014. PMID: 23910730 Review.
HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 is expressed at the cell surface of antigen presenting cells (APC) both as canonical beta2m-associated and non-canonical beta2m-free heavy chain (FHC) fo …
HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 is expressed at the cell surface of an …
Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue.
Rysnik O, McHugh K, van Duivenvoorde L, van Tok M, Guggino G, Taurog J, Kollnberger S, Ciccia F, Baeten D, Bowness P. Rysnik O, et al. J Autoimmun. 2016 Jun;70:12-21. doi: 10.1016/j.jaut.2016.03.009. Epub 2016 Mar 29. J Autoimmun. 2016. PMID: 27036372 Free PMC article.
OBJECTIVES: Human leukocyte antigen (HLA)-B27 (B27) is the strongest genetic factor associated with development of Ankylosing Spondylitis and other spondyloarthropathies (SpA), yet the role it plays in disease pathogenesis remains unclear. We investiga …
OBJECTIVES: Human leukocyte antigen (HLA)-B27 (B27) is the strongest genetic factor associated with development …
Cell-surface expression and immune receptor recognition of HLA-B27 homodimers.
Kollnberger S, Bird L, Sun MY, Retiere C, Braud VM, McMichael A, Bowness P. Kollnberger S, et al. Arthritis Rheum. 2002 Nov;46(11):2972-82. doi: 10.1002/art.10605. Arthritis Rheum. 2002. PMID: 12428240
OBJECTIVE: HLA-B27 is capable of forming in vitro a heavy-chain homodimer structure lacking beta(2)-microglobulin. We undertook this study to ascertain if patients with spondylarthritis express beta(2)-microglobulin-free HLA-B27 …
OBJECTIVE: HLA-B27 is capable of forming in vitro a heavy-chain homodimer structure lacking beta(2)-microglobuli …
Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.
Payeli SK, Kollnberger S, Marroquin Belaunzaran O, Thiel M, McHugh K, Giles J, Shaw J, Kleber S, Ridley A, Wong-Baeza I, Keidel S, Kuroki K, Maenaka K, Wadle A, Renner C, Bowness P. Payeli SK, et al. Arthritis Rheum. 2012 Oct;64(10):3139-49. doi: 10.1002/art.34538. Arthritis Rheum. 2012. PMID: 22576154
OBJECTIVE: Spondylarthritides (SpA), including ankylosing spondylitis (AS), are common inflammatory rheumatic diseases that are strongly associated with positivity for the HLA class I allotype B27. HLA-B27 normally forms complexes with beta(2) -microgl …
OBJECTIVE: Spondylarthritides (SpA), including ankylosing spondylitis (AS), are common inflammatory rheumatic diseases that are strongly ass …
New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.
Shaw J, Kollnberger S. Shaw J, et al. Front Immunol. 2012 Nov 16;3:339. doi: 10.3389/fimmu.2012.00339. eCollection 2012. Front Immunol. 2012. PMID: 23162554 Free PMC article.
KIR3DL2 binds to HLA-A3 and -A11 in a peptide-dependent fashion and to B27 free heavy chain forms. ...Moreover, KIR3DL2 expression delineates circulating and cutaneous lymphoma T cells in Sezary's syndrome. ...
KIR3DL2 binds to HLA-A3 and -A11 in a peptide-dependent fashion and to B27 free heavy chain forms. …
11 results