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27 results

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HMGA1 Promotes Macrophage Recruitment via Activation of NF-κB-CCL2 Signaling in Hepatocellular Carcinoma.
Chen J, Ji K, Gu L, Fang Y, Pan M, Tian S. Chen J, et al. J Immunol Res. 2022 Jun 22;2022:4727198. doi: 10.1155/2022/4727198. eCollection 2022. J Immunol Res. 2022. PMID: 35785026 Free PMC article.
Deletion of macrophages with clodronate liposomes significantly abrogated the tumor-promoting effects of HMGA1 on HCC growth. ...CONCLUSIONS: This study reveals HMGA1 as a crucial regulator of macrophage recruitment by activating NF-kappaB-CCL2 signali …
Deletion of macrophages with clodronate liposomes significantly abrogated the tumor-promoting effects of HMGA1 on HCC growth. …
Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis.
Ahmad P, Alvi SS, Iqbal D, Khan MS. Ahmad P, et al. Life Sci. 2020 Aug 1;254:117756. doi: 10.1016/j.lfs.2020.117756. Epub 2020 May 7. Life Sci. 2020. PMID: 32389832 Review.
The initial part of this report specifically explains distinct sequential mechanisms underlying the initiation and development of atherosclerotic plaques and later part deals with the pharmacological efficacy of PD in the management of major cardiac event i.e. atherosclerotic car …
The initial part of this report specifically explains distinct sequential mechanisms underlying the initiation and development of atheroscle …
Integrative analysis reveals key mRNAs and lncRNAs in monocytes of osteoporotic patients.
Li L, Wang XQ, Liu XT, Guo R, Zhang RD. Li L, et al. Math Biosci Eng. 2019 Jun 27;16(5):5947-5971. doi: 10.3934/mbe.2019298. Math Biosci Eng. 2019. PMID: 31499747 Free article.
In addition, we also highlighted one lncRNA, RP11-498C9.17, was highly correlated with epigenetic regulators, such as HDAC4, MORF4L1, HMGA1 and DND1, indicating that the lncRNA RP11-498C9.17 may also be an epigenetic regulator. ...
In addition, we also highlighted one lncRNA, RP11-498C9.17, was highly correlated with epigenetic regulators, such as HDAC4, MORF4L1, HMG
High-Mobility Group AT-Hook 1 Served as a Prognosis Biomarker and Associated with Immune Infiltrate in Hepatocellular Carcinoma.
Wei YG, Yang CK, Wei ZL, Liao XW, He YF, Zhou X, Huang HS, Lan CL, Han CY, Peng T. Wei YG, et al. Int J Gen Med. 2022 Jan 14;15:609-621. doi: 10.2147/IJGM.S344858. eCollection 2022. Int J Gen Med. 2022. PMID: 35058711 Free PMC article.
Notably, HMGA1 may be associated with TP53 mutational carcinogenesis. Moreover, increased HMGA1 expression may lead to an increase in immune infiltration and a decrease in tumor purity in HCC. CIBERSORT analysis elucidated that the amount of B cell naive, B cell mem …
Notably, HMGA1 may be associated with TP53 mutational carcinogenesis. Moreover, increased HMGA1 expression may lead to an incr …
Acute transcriptomic changes in murine RAW 264.7 cells following pseudorabies virus infection.
Tong C, Fu PF, Ming SL, Zeng L, Zhu HS, Wang J. Tong C, et al. Arch Virol. 2022 Dec;167(12):2623-2631. doi: 10.1007/s00705-022-05598-1. Epub 2022 Oct 21. Arch Virol. 2022. PMID: 36269412
Seven differentially expressed genes (Trim27, Ccdc117, Mrps12, Ccl4, Cerkl, Ubald1, and Hmga1-rs1) were present across all treatment groups. Our findings expand our knowledge of gene regulation and immune response following PRV infection. ...
Seven differentially expressed genes (Trim27, Ccdc117, Mrps12, Ccl4, Cerkl, Ubald1, and Hmga1-rs1) were present across all treatment …
A2AR Expression and Immunosuppressive Environment Independent of KRAS and GNAS Mutations in Pseudomyxoma Peritonei.
Kusamura S, Busico A, Conca E, Capone I, Agnelli L, Lorenzini D, Brich S, Angelini M, Volpi CC, Trupia DV, Lagano V, Torelli T, Gloghini A, Baratti D, Guaglio M, Milione M, Deraco M, Perrone F. Kusamura S, et al. Biomedicines. 2023 Jul 20;11(7):2049. doi: 10.3390/biomedicines11072049. Biomedicines. 2023. PMID: 37509688 Free PMC article.
The tumor microenvironment showed the presence of CD4+ T cells (86%); CD8+ T cells (27%); CD20+ B (67%); CD15+ cells (86%); and CD163+ M2 macrophages (67%), while CD56+ NK cells were absent. CD163 expression (27%) in PMP tumor cells was associated with poor prognosis. ...T …
The tumor microenvironment showed the presence of CD4+ T cells (86%); CD8+ T cells (27%); CD20+ B (67%); CD15+ cells (86%); and CD163+ M2 …
HCG18 Participates in Vascular Invasion of Hepatocellular Carcinoma by Regulating Macrophages and Tumor Stem Cells.
Zhang L, Wang Z, Li M, Sun P, Bai T, Wang W, Bai H, Gou J, Wang Z. Zhang L, et al. Front Cell Dev Biol. 2021 Aug 30;9:707073. doi: 10.3389/fcell.2021.707073. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34527669 Free PMC article.
Cluster analysis based on patient prognosis suggested that regulating phenotypic transformation of macrophages could be an effective intervention for treating HCC. At the same time, higher expression of HCG18, HMGA1, ILF2, and YBX1 was associated with a higher stem …
Cluster analysis based on patient prognosis suggested that regulating phenotypic transformation of macrophages could be an effective …
HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization.
Tang C, Lei X, Xiong L, Hu Z, Tang B. Tang C, et al. Cell Death Dis. 2021 Apr 29;12(5):422. doi: 10.1038/s41419-021-03703-x. Cell Death Dis. 2021. PMID: 33927188 Free PMC article.
Tumor-associated macrophages (TAMs) in the tumor microenvironment contribute to poor prognosis in gastric cancer (GC). ...POU1F1 also promoted GC metastasis in lung by modulating macrophage polarization through CXCL12/CXCR4 axis in vivo. HMGA1B/2-upregulated …
Tumor-associated macrophages (TAMs) in the tumor microenvironment contribute to poor prognosis in gastric cancer (GC). ...POU1F1 also …
Meta-analysis identifying epithelial-derived transcriptomes predicts poor clinical outcome and immune infiltrations in ovarian cancer.
Li DF, Tulahong A, Uddin MN, Zhao H, Zhang H. Li DF, et al. Math Biosci Eng. 2021 Jul 30;18(5):6527-6551. doi: 10.3934/mbe.2021324. Math Biosci Eng. 2021. PMID: 34517544 Free article.
We identified 21 (such as E2F4, FOXM1, TFDP1, E2F1, and SIN3A) and 11 (such as JUN, DDX4, FOSL1, NOC2L, and HMGA1) master transcriptional regulators (MTRs) that are interacted with upregulated and the downregulated genes in ovarian tumor epithelium, respectively. ...Moreov …
We identified 21 (such as E2F4, FOXM1, TFDP1, E2F1, and SIN3A) and 11 (such as JUN, DDX4, FOSL1, NOC2L, and HMGA1) master transcripti …
Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation.
Battista S, Pentimalli F, Baldassarre G, Fedele M, Fidanza V, Croce CM, Fusco A. Battista S, et al. FASEB J. 2003 Aug;17(11):1496-8. doi: 10.1096/fj.02-0977fje. Epub 2003 Jun 17. FASEB J. 2003. PMID: 12824305
To assess their role in development, we studied the in vitro differentiation of embryonic stem (ES) cells that bear one or both disrupted Hmga1 alleles. Here, we report that Hmga1 null ES cells generate fewer T-cell precursors than do wild-type ES cells. ...Re-expre …
To assess their role in development, we studied the in vitro differentiation of embryonic stem (ES) cells that bear one or both disrupted …
27 results