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30 results

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Page 1
HMGA1 Promotes Macrophage Recruitment via Activation of NF-kappaB-CCL2 Signaling in Hepatocellular Carcinoma.
Chen J, Ji K, Gu L, Fang Y, Pan M, Tian S. Chen J, et al. J Immunol Res. 2022 Jun 22;2022:4727198. doi: 10.1155/2022/4727198. eCollection 2022. J Immunol Res. 2022. PMID: 35785026 Free PMC article.
RESULTS: The high mobility group A1 (HMGA1) gene was identified as a putative modulator of macrophage infiltration in HCC. ...CONCLUSIONS: This study reveals HMGA1 as a crucial regulator of macrophage recruitment by activating NF-kappaB-CCL2 signaling, …
RESULTS: The high mobility group A1 (HMGA1) gene was identified as a putative modulator of macrophage infiltration in HCC. ... …
miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosis.
Xue Z, Guo Y, Wang F, Yang Q, Chen Q, Lin T, Lin S. Xue Z, et al. Iran J Immunol. 2024 Sep 7;21(3):201-211. doi: 10.22034/iji.2024.102744.2794. Online ahead of print. Iran J Immunol. 2024. PMID: 39243139 Free article.
RESULTS: Significantly reduced levels of miR-196b-5p, and increased levels of SOCS1, HMGA1, and CCL2 were observed in the ectopic endometrium of mice with endometriosis. The miR-196b-5p mimic significantly reduced the lesion size, increased M1 macrophages, and decre …
RESULTS: Significantly reduced levels of miR-196b-5p, and increased levels of SOCS1, HMGA1, and CCL2 were observed in the ectopic end …
The RP11-417E7.1/THBS2 signaling pathway promotes colorectal cancer metastasis by activating the Wnt/beta-catenin pathway and facilitating exosome-mediated M2 macrophage polarization.
Liu Y, Lv H, Liu X, Xu L, Li T, Zhou H, Zhu H, Hao C, Lin C, Zhang Y. Liu Y, et al. J Exp Clin Cancer Res. 2024 Jul 17;43(1):195. doi: 10.1186/s13046-024-03107-7. J Exp Clin Cancer Res. 2024. PMID: 39020380 Free PMC article.
Mechanistically, RP11-417E7.1 binding with High mobility group A1 (HMGA1) promotes neighboring thrombospondin 2 (THBS2) transcription via chromatin loop formation between its promoter and enhancer, which activates the Wnt/beta-catenin signaling pathway and facilitates CRC …
Mechanistically, RP11-417E7.1 binding with High mobility group A1 (HMGA1) promotes neighboring thrombospondin 2 (THBS2) transcription …
A2AR Expression and Immunosuppressive Environment Independent of KRAS and GNAS Mutations in Pseudomyxoma Peritonei.
Kusamura S, Busico A, Conca E, Capone I, Agnelli L, Lorenzini D, Brich S, Angelini M, Volpi CC, Trupia DV, Lagano V, Torelli T, Gloghini A, Baratti D, Guaglio M, Milione M, Deraco M, Perrone F. Kusamura S, et al. Biomedicines. 2023 Jul 20;11(7):2049. doi: 10.3390/biomedicines11072049. Biomedicines. 2023. PMID: 37509688 Free PMC article.
The tumor microenvironment showed the presence of CD4+ T cells (86%); CD8+ T cells (27%); CD20+ B (67%); CD15+ cells (86%); and CD163+ M2 macrophages (67%), while CD56+ NK cells were absent. CD163 expression (27%) in PMP tumor cells was associated with poor prognosis. ...T …
The tumor microenvironment showed the presence of CD4+ T cells (86%); CD8+ T cells (27%); CD20+ B (67%); CD15+ cells (86%); and CD163+ M2 …
Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study.
Guo X, Jin W, Wen Y, Wang Z, Ren X, Liu Z, Fu R, Cai Z, Li L. Guo X, et al. J Transl Med. 2024 Jul 20;22(1):673. doi: 10.1186/s12967-024-05496-x. J Transl Med. 2024. PMID: 39033303 Free PMC article.
While no significant increase in mutation burden was observed, high-risk MDS patients exhibited T-cell activation and abnormal myelogenesis at the stages between hematopoietic stem and progenitor cells (HSPC) and granulocyte-macrophage progenitors (GMP). Transcriptional fa …
While no significant increase in mutation burden was observed, high-risk MDS patients exhibited T-cell activation and abnormal myelogenesis …
HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization.
Tang C, Lei X, Xiong L, Hu Z, Tang B. Tang C, et al. Cell Death Dis. 2021 Apr 29;12(5):422. doi: 10.1038/s41419-021-03703-x. Cell Death Dis. 2021. PMID: 33927188 Free PMC article.
Tumor-associated macrophages (TAMs) in the tumor microenvironment contribute to poor prognosis in gastric cancer (GC). ...POU1F1 also promoted GC metastasis in lung by modulating macrophage polarization through CXCL12/CXCR4 axis in vivo. HMGA1B/2-upregulated …
Tumor-associated macrophages (TAMs) in the tumor microenvironment contribute to poor prognosis in gastric cancer (GC). ...POU1F1 also …
Integrated bulk and scRNA sequence identified anoikis-related diagnostic biomarkers and potential association with immune infiltration in type A aortic dissection.
Feng K, Zhang Z, Luo J, Wang W, Li T, Luo J, Huang H. Feng K, et al. Aging (Albany NY). 2023 Oct 24;15(20):11268-11285. doi: 10.18632/aging.205126. Epub 2023 Oct 24. Aging (Albany NY). 2023. PMID: 37877967 Free PMC article.
In this study, we first identified and validated eight diagnostic ARGs for TAAD based on multiple RNA-sequence datasets, including CHEK2, HIF1A, HK2, HMGA1, SERPINA1, PTPN1, SLC2A1 and VEGFA. The comprehensive functional annotation was evaluated by the integrated functiona …
In this study, we first identified and validated eight diagnostic ARGs for TAAD based on multiple RNA-sequence datasets, including CHEK2, HI …
Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis.
Ahmad P, Alvi SS, Iqbal D, Khan MS. Ahmad P, et al. Life Sci. 2020 Aug 1;254:117756. doi: 10.1016/j.lfs.2020.117756. Epub 2020 May 7. Life Sci. 2020. PMID: 32389832 Review.
The initial part of this report specifically explains distinct sequential mechanisms underlying the initiation and development of atherosclerotic plaques and later part deals with the pharmacological efficacy of PD in the management of major cardiac event i.e. atherosclerotic car …
The initial part of this report specifically explains distinct sequential mechanisms underlying the initiation and development of atheroscle …
High-Mobility Group AT-Hook 1 Served as a Prognosis Biomarker and Associated with Immune Infiltrate in Hepatocellular Carcinoma.
Wei YG, Yang CK, Wei ZL, Liao XW, He YF, Zhou X, Huang HS, Lan CL, Han CY, Peng T. Wei YG, et al. Int J Gen Med. 2022 Jan 14;15:609-621. doi: 10.2147/IJGM.S344858. eCollection 2022. Int J Gen Med. 2022. PMID: 35058711 Free PMC article.
Notably, HMGA1 may be associated with TP53 mutational carcinogenesis. Moreover, increased HMGA1 expression may lead to an increase in immune infiltration and a decrease in tumor purity in HCC. CIBERSORT analysis elucidated that the amount of B cell naive, B cell mem …
Notably, HMGA1 may be associated with TP53 mutational carcinogenesis. Moreover, increased HMGA1 expression may lead to an incr …
Acute transcriptomic changes in murine RAW 264.7 cells following pseudorabies virus infection.
Tong C, Fu PF, Ming SL, Zeng L, Zhu HS, Wang J. Tong C, et al. Arch Virol. 2022 Dec;167(12):2623-2631. doi: 10.1007/s00705-022-05598-1. Epub 2022 Oct 21. Arch Virol. 2022. PMID: 36269412
Seven differentially expressed genes (Trim27, Ccdc117, Mrps12, Ccl4, Cerkl, Ubald1, and Hmga1-rs1) were present across all treatment groups. Our findings expand our knowledge of gene regulation and immune response following PRV infection. ...
Seven differentially expressed genes (Trim27, Ccdc117, Mrps12, Ccl4, Cerkl, Ubald1, and Hmga1-rs1) were present across all treatment …
30 results