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Page 1
HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes.
Ng NHJ, Ghosh S, Bok CM, Ching C, Low BSJ, Chen JT, Lim E, Miserendino MC, Tan YS, Hoon S, Teo AKK. Ng NHJ, et al. Nat Commun. 2024 Jun 22;15(1):4288. doi: 10.1038/s41467-024-48647-w. Nat Commun. 2024. PMID: 38909044 Free PMC article.
To better define the pleiotropic gene regulatory roles of HNF4A and HNF1A, we generated a comprehensive genome-wide map of their binding targets in pancreatic and hepatic cells using ChIP-Seq. ...Overall, our studies provide a rich resource for uncovering downstream …
To better define the pleiotropic gene regulatory roles of HNF4A and HNF1A, we generated a comprehensive genome-wide map of the …
Reduced penetrance of MODY-associated HNF1A/HNF4A variants but not GCK variants in clinically unselected cohorts.
Mirshahi UL, Colclough K, Wright CF, Wood AR, Beaumont RN, Tyrrell J, Laver TW, Stahl R, Golden A, Goehringer JM; Geisinger-Regeneron DiscovEHR Collaboration; Frayling TF, Hattersley AT, Carey DJ, Weedon MN, Patel KA. Mirshahi UL, et al. Am J Hum Genet. 2022 Nov 3;109(11):2018-2028. doi: 10.1016/j.ajhg.2022.09.014. Epub 2022 Oct 17. Am J Hum Genet. 2022. PMID: 36257325 Free PMC article.
We show that one in 1,500 individuals harbor a pathogenic variant in one of these genes. The penetrance of diabetes for HNF1A and HNF4A pathogenic variants was substantially lower in the clinically unselected individuals compared to clinically referred probands and …
We show that one in 1,500 individuals harbor a pathogenic variant in one of these genes. The penetrance of diabetes for HNF1A …
HNF1A gene mutations and premature ovarian failure (POF): evidence from a clinical paradigm combining MODY 3 and POF.
Xekouki P, Konstantinidou A, Tatsi C, Sertedaki A, Settas N, Loutradis D, Chrousos GP, Kanaka-Gantenbein C, Dacou-Voutetakis C, Voutetakis A. Xekouki P, et al. Hormones (Athens). 2024 Jun;23(2):345-350. doi: 10.1007/s42000-024-00529-y. Epub 2024 Feb 5. Hormones (Athens). 2024. PMID: 38311659 Free PMC article. Review.
Maturity-onset diabetes of the young (MODY), caused by mutations in the HNF1A gene, is also a rare disorder; all types of MODY account for 1-2% of adult diabetic cases. ...HNF1A protein was expressed in both the fetal and adult human ovaries. Based on these f …
Maturity-onset diabetes of the young (MODY), caused by mutations in the HNF1A gene, is also a rare disorder; all types of MODY …
HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey.
Beysel S, Eyerci N, Pinarli FA, Kizilgul M, Ozcelik O, Caliskan M, Cakal E. Beysel S, et al. BMC Endocr Disord. 2019 May 20;19(1):51. doi: 10.1186/s12902-019-0375-2. BMC Endocr Disord. 2019. PMID: 31109344 Free PMC article.
After genetic analysis, diabetics (n = 46) with HNF1A, HNF1B, HNF4A, GCK gene mutations (diagnosed as MODY) and diabetics (n = 30) with HNF1B, HNF4A, GCK gene SNPs were excluded. ...HNF1A gene p.I27L SNP might contribute to age at diabetes diagn …
After genetic analysis, diabetics (n = 46) with HNF1A, HNF1B, HNF4A, GCK gene mutations (diagnosed as MODY) and diabetics (n = …
Novel insights into genetics and clinics of the HNF1A-MODY.
Valkovicova T, Skopkova M, Stanik J, Gasperikova D. Valkovicova T, et al. Endocr Regul. 2019 Apr 1;53(2):110-134. doi: 10.2478/enr-2019-0013. Endocr Regul. 2019. PMID: 31517624 Free article. Review.
MODY (Maturity Onset Diabetes of the Young) is a type of diabetes resulting from a pathogenic effect of gene mutations. Up to date, 13 MODY genes are known. Gene HNF1A is one of the most common causes of MODY diabetes (HNF1A-MODY; MODY3). This …
MODY (Maturity Onset Diabetes of the Young) is a type of diabetes resulting from a pathogenic effect of gene mutations. Up to date, 1 …
HNF1A-AS1: A Tumor-associated Long Non-coding RNA.
Liu Y, Zhao F, Tan F, Tang L, Du Z, Mou J, Zhou G, Yuan C. Liu Y, et al. Curr Pharm Des. 2022;28(21):1720-1729. doi: 10.2174/1381612828666220520113846. Curr Pharm Des. 2022. PMID: 35619319 Review.
RESULTS: This is a review paper about the tumor-associated long non-coding RNA HNF1A-AS1. Many researches show that LncRNA HNF1A-AS1 is related to the development of tumorous tumors. ...HNF1A-AS1 can also influence the development of tumors by regulating EMT. …
RESULTS: This is a review paper about the tumor-associated long non-coding RNA HNF1A-AS1. Many researches show that LncRNA HNF1A …
A study of associations between CUBN, HNF1A, and LIPC gene polymorphisms and coronary artery disease.
Park HS, Kim IJ, Kim EG, Ryu CS, Lee JY, Ko EJ, Park HW, Sung JH, Kim NK. Park HS, et al. Sci Rep. 2020 Oct 1;10(1):16294. doi: 10.1038/s41598-020-73048-6. Sci Rep. 2020. PMID: 33004870 Free PMC article.
The aim of this study was to identify novel genetic markers related to coronary artery disease (CAD) using a whole-exome sequencing (WES) approach and determine any associations between the selected gene polymorphisms and CAD prevalence. CUBN, HNF1A and LIPC gene …
The aim of this study was to identify novel genetic markers related to coronary artery disease (CAD) using a whole-exome sequencing (WES) ap …
Differential expression of HNF1A and HNF1A-AS1 in colon cancer cells.
Sepehri Z, Banerjee A, Vizeacoumar FS, Freywald A, Vizeacoumar FJ, Dolinsky VW, Davie JR. Sepehri Z, et al. IUBMB Life. 2022 Jun;74(6):496-507. doi: 10.1002/iub.2609. Epub 2022 Mar 2. IUBMB Life. 2022. PMID: 35184384 Free article.
The human hepatocyte nuclear factor 1 homeobox A (HNF1A) gene loci express the protein-coding HNF1A transcript and a long non-coding RNA in the anti-sense (HNF1A-AS1) direction. ...The HT-29 HNF1A gene had active histone marks (H3K4me3, H …
The human hepatocyte nuclear factor 1 homeobox A (HNF1A) gene loci express the protein-coding HNF1A transcript and a lo …
Association study of C-reactive protein associated gene HNF1A with ischemic stroke in Chinese population.
Shi H, Leng S, Liang H, Zheng Y, Chen L. Shi H, et al. BMC Med Genet. 2016 Jul 26;17(1):51. doi: 10.1186/s12881-016-0313-3. BMC Med Genet. 2016. PMID: 27460564 Free PMC article.
Therefore, the C-reactive protein associated gene HNF1A seems to be a promising candidate gene for ischemic stroke. RESULTS: We used HNF1A as a candidate gene of ischemic stroke and evaluated seven common variants of HNF1A for their contr …
Therefore, the C-reactive protein associated gene HNF1A seems to be a promising candidate gene for ischemic stroke. RES …
Variants influencing age at diagnosis of HNF1A-MODY.
Ludwig-Słomczyńska AH, Seweryn MT, Radkowski P, Kapusta P, Machlowska J, Pruhova S, Gasperikova D, Bellanne-Chantelot C, Hattersley A, Kandasamy B, Letourneau-Freiberg L, Philipson L, Doria A, Wołkow PP, Małecki MT, Klupa T. Ludwig-Słomczyńska AH, et al. Mol Med. 2022 Sep 14;28(1):113. doi: 10.1186/s10020-022-00542-0. Mol Med. 2022. PMID: 36104811 Free PMC article.
BACKGROUND: HNF1A-MODY is a monogenic form of diabetes caused by variants in the HNF1A gene. Different HNF1A variants are associated with differences in age of disease onset, but other factors are postulated to influence this trait. ...In the linear mi …
BACKGROUND: HNF1A-MODY is a monogenic form of diabetes caused by variants in the HNF1A gene. Different HNF1A var …
1,689 results