Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 1
1998 3
2000 1
2001 2
2002 3
2003 3
2004 4
2005 5
2006 8
2007 8
2008 6
2009 7
2010 8
2011 6
2012 6
2013 9
2014 12
2015 6
2016 7
2017 7
2018 12
2019 10
2020 16
2021 9
2022 5
2023 3

Text availability

Article attribute

Article type

Publication date

Search Results

147 results

Results by year

Filters applied: . Clear all
Page 1
Mettl3-mediated mRNA m6A modification controls postnatal liver development by modulating the transcription factor Hnf4a.
Xu Y, Zhou Z, Kang X, Pan L, Liu C, Liang X, Chu J, Dong S, Li Y, Liu Q, Sun Y, Yu S, Zhang Q. Xu Y, et al. Nat Commun. 2022 Aug 5;13(1):4555. doi: 10.1038/s41467-022-32169-4. Nat Commun. 2022. PMID: 35931692 Free PMC article.
Deleting Mettl3 reduces m(6)A modification on Hnf4a, decreases its transcript stability in an Igf2bp1-dependent manner, and down-regulates Hnf4a expression, while overexpressing Hnf4a with AAV8 alleviates the liver injury and prolongs the lifespan of M …
Deleting Mettl3 reduces m(6)A modification on Hnf4a, decreases its transcript stability in an Igf2bp1-dependent manner, and down-regu …
Maturity-onset diabetes of the young (MODY): an update.
Anık A, Çatlı G, Abacı A, Böber E. Anık A, et al. J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):251-63. doi: 10.1515/jpem-2014-0384. J Pediatr Endocrinol Metab. 2015. PMID: 25581748 Review.
GCK mutations cause a mild, asymptomatic, and stable fasting hyperglycemia usually requiring no specific treatment. However, mutations in the HNF1A and HNF4A cause a progressive pancreatic beta-cell dysfunction and hyperglycemia that can result in microvascular complicatio …
GCK mutations cause a mild, asymptomatic, and stable fasting hyperglycemia usually requiring no specific treatment. However, mutations in th …
Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma.
Montal R, Sia D, Montironi C, Leow WQ, Esteban-Fabró R, Pinyol R, Torres-Martin M, Bassaganyas L, Moeini A, Peix J, Cabellos L, Maeda M, Villacorta-Martin C, Tabrizian P, Rodriguez-Carunchio L, Castellano G, Sempoux C, Minguez B, Pawlik TM, Labgaa I, Roberts LR, Sole M, Fiel MI, Thung S, Fuster J, Roayaie S, Villanueva A, Schwartz M, Llovet JM. Montal R, et al. J Hepatol. 2020 Aug;73(2):315-327. doi: 10.1016/j.jhep.2020.03.008. Epub 2020 Mar 12. J Hepatol. 2020. PMID: 32173382 Free PMC article.
Tumors classified within the Metabolic class (19%) showed a hepatocyte-like phenotype with activation of the transcription factor HNF4A and enrichment in gene signatures related to bile acid metabolism. ...
Tumors classified within the Metabolic class (19%) showed a hepatocyte-like phenotype with activation of the transcription factor HNF4A …
Hepatogenic Potential and Liver Regeneration Effect of Human Liver-derived Mesenchymal-Like Stem Cells.
Lee J, Choi J, Kang S, Kim J, Lee R, So S, Yoon YI, Kirchner VA, Song GW, Hwang S, Lee SG, Kang E, Tak E. Lee J, et al. Cells. 2020 Jun 22;9(6):1521. doi: 10.3390/cells9061521. Cells. 2020. PMID: 32580448 Free PMC article.
Human liver-derived stem cells (hLD-SCs) have been proposed as a possible resource for stem cell therapy in patients with irreversible liver diseases. ...Moreover, hLD-SCs featured higher numbers of hepatic progenitor cell markers on day 14 of differentiation (CPM a …
Human liver-derived stem cells (hLD-SCs) have been proposed as a possible resource for stem cell therapy in patients with irreversibl …
Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases.
Yeh MM, Bosch DE, Daoud SS. Yeh MM, et al. World J Gastroenterol. 2019 Aug 14;25(30):4074-4091. doi: 10.3748/wjg.v25.i30.4074. World J Gastroenterol. 2019. PMID: 31435165 Free PMC article. Review.
Hepatocyte nuclear factor 4-alpha (HNF4alpha) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4alpha is bes …
Hepatocyte nuclear factor 4-alpha (HNF4alpha) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription …
Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers.
Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Mordaunt CE, et al. Epigenetics Chromatin. 2019 Feb 1;12(1):10. doi: 10.1186/s13072-019-0255-z. Epigenetics Chromatin. 2019. PMID: 30709419 Free PMC article.
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters, and binding sites of liver developmental transcription factors, including Hepatocyte Nuclear Factor 4 alpha ( …
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active …
Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival.
Hang HL, Liu XY, Wang HT, Xu N, Bian JM, Zhang JJ, Xia L, Xia Q. Hang HL, et al. Exp Cell Res. 2017 Nov 15;360(2):81-93. doi: 10.1016/j.yexcr.2017.08.020. Epub 2017 Sep 6. Exp Cell Res. 2017. PMID: 28870599
This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A) in hepatic differentiation of IHH, and whether encapsulation of IHH overexpressing HNF4A could improve liver function and survival in rats with acute liver failure (ALF). .. …
This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A) in hepatic differentiation of IHH, and whether encapsu …
Genetic and epigenetic regulation of gene expression in fetal and adult human livers.
Bonder MJ, Kasela S, Kals M, Tamm R, Lokk K, Barragan I, Buurman WA, Deelen P, Greve JW, Ivanov M, Rensen SS, van Vliet-Ostaptchouk JV, Wolfs MG, Fu J, Hofker MH, Wijmenga C, Zhernakova A, Ingelman-Sundberg M, Franke L, Milani L. Bonder MJ, et al. BMC Genomics. 2014 Oct 4;15(1):860. doi: 10.1186/1471-2164-15-860. BMC Genomics. 2014. PMID: 25282492 Free PMC article.
BACKGROUND: The liver plays a central role in the maintenance of homeostasis and health in general. ...RESULTS: By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers, we identified 657 differentially methylated genes with adult …
BACKGROUND: The liver plays a central role in the maintenance of homeostasis and health in general. ...RESULTS: By analyzing the meth …
The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation.
Sartor C, Bachelot L, Godard C, Lager F, Renault G, Gonzalez FJ, Perret C, Gougelet A, Colnot S. Sartor C, et al. Liver Int. 2019 Apr;39(4):727-739. doi: 10.1111/liv.14068. Epub 2019 Feb 24. Liver Int. 2019. PMID: 30721564 Free PMC article.
In addition, increasing HNF4alpha level by miR-34a inhibition slowed tumour progression of beta-catenin-activated HCC in mice. METHODS: We generated a Hnf4a(flox/flox/) Apc(flox/flox) /TTR-Cre(ERT)(2) (Hnf4a/Apc(Hep) ) mouse line and evaluated the impact of Hnf4a …
In addition, increasing HNF4alpha level by miR-34a inhibition slowed tumour progression of beta-catenin-activated HCC in mice. METHODS: We g …
Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis.
Cheng CC, Yang WY, Hsiao MC, Lin KH, Lee HW, Yuh CH. Cheng CC, et al. Biomolecules. 2020 Jun 12;10(6):898. doi: 10.3390/biom10060898. Biomolecules. 2020. PMID: 32545625 Free PMC article.
Oligo-fucoidan pretreatment also decreases the expression of lipogenic enzymes and liver fibrosis genes. Using pathway analysis, we identify hepatocyte nuclear factor 4 alpha (HNF4A) to be the potential driver gene. We further investigate whether hepatocyte nuclear …
Oligo-fucoidan pretreatment also decreases the expression of lipogenic enzymes and liver fibrosis genes. Using pathway analysis, we i …
147 results