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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 1
1998 3
2000 1
2001 2
2002 3
2003 3
2004 4
2005 5
2006 8
2007 8
2008 6
2009 7
2010 8
2011 6
2012 6
2013 9
2014 12
2015 6
2016 7
2017 7
2018 12
2019 10
2020 16
2021 9
2022 1
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140 results
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Page 1
Maturity-onset diabetes of the young (MODY): an update.
Anık A, Çatlı G, Abacı A, Böber E. Anık A, et al. J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):251-63. doi: 10.1515/jpem-2014-0384. J Pediatr Endocrinol Metab. 2015. PMID: 25581748 Review.
GCK mutations cause a mild, asymptomatic, and stable fasting hyperglycemia usually requiring no specific treatment. However, mutations in the HNF1A and HNF4A cause a progressive pancreatic beta-cell dysfunction and hyperglycemia that can result in microvascular complicatio …
GCK mutations cause a mild, asymptomatic, and stable fasting hyperglycemia usually requiring no specific treatment. However, mutations in th …
circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.
Zhang X, Xu Y, Qian Z, Zheng W, Wu Q, Chen Y, Zhu G, Liu Y, Bian Z, Xu W, Zhang Y, Sun F, Pan Q, Wang J, Du L, Yu Y. Zhang X, et al. Cell Death Dis. 2018 Oct 25;9(11):1091. doi: 10.1038/s41419-018-1132-6. Cell Death Dis. 2018. PMID: 30361504 Free PMC article.
Here, we identified that circRNA_104075 (circ_104075) was highly expressed in HCC tissues, cell lines and serum. Mechanistically, HNF4a bound to the -1409 to -1401 region of the circ_104075 promoter to stimulate the expression of circ_104075. ...
Here, we identified that circRNA_104075 (circ_104075) was highly expressed in HCC tissues, cell lines and serum. Mechanistically, HNF4a
Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma.
Montal R, Sia D, Montironi C, Leow WQ, Esteban-Fabró R, Pinyol R, Torres-Martin M, Bassaganyas L, Moeini A, Peix J, Cabellos L, Maeda M, Villacorta-Martin C, Tabrizian P, Rodriguez-Carunchio L, Castellano G, Sempoux C, Minguez B, Pawlik TM, Labgaa I, Roberts LR, Sole M, Fiel MI, Thung S, Fuster J, Roayaie S, Villanueva A, Schwartz M, Llovet JM. Montal R, et al. J Hepatol. 2020 Aug;73(2):315-327. doi: 10.1016/j.jhep.2020.03.008. Epub 2020 Mar 12. J Hepatol. 2020. PMID: 32173382 Free PMC article.
Tumors classified within the Metabolic class (19%) showed a hepatocyte-like phenotype with activation of the transcription factor HNF4A and enrichment in gene signatures related to bile acid metabolism. ...
Tumors classified within the Metabolic class (19%) showed a hepatocyte-like phenotype with activation of the transcription factor HNF4A
Hepatogenic Potential and Liver Regeneration Effect of Human Liver-derived Mesenchymal-Like Stem Cells.
Lee J, Choi J, Kang S, Kim J, Lee R, So S, Yoon YI, Kirchner VA, Song GW, Hwang S, Lee SG, Kang E, Tak E. Lee J, et al. Cells. 2020 Jun 22;9(6):1521. doi: 10.3390/cells9061521. Cells. 2020. PMID: 32580448 Free PMC article.
Human liver-derived stem cells (hLD-SCs) have been proposed as a possible resource for stem cell therapy in patients with irreversible liver diseases. ...Moreover, hLD-SCs featured higher numbers of hepatic progenitor cell markers on day 14 of differentiation (CPM a …
Human liver-derived stem cells (hLD-SCs) have been proposed as a possible resource for stem cell therapy in patients with irreversibl …
Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.
Huang P, Zhang L, Gao Y, He Z, Yao D, Wu Z, Cen J, Chen X, Liu C, Hu Y, Lai D, Hu Z, Chen L, Zhang Y, Cheng X, Ma X, Pan G, Wang X, Hui L. Huang P, et al. Cell Stem Cell. 2014 Mar 6;14(3):370-84. doi: 10.1016/j.stem.2014.01.003. Epub 2014 Feb 27. Cell Stem Cell. 2014. PMID: 24582927 Free article.
The generation of large numbers of functional human hepatocytes for cell-based approaches to liver disease is an important and unmet goal. Direct reprogramming of fibroblasts to hepatic lineages could offer a solution to this problem but so far has only been achieved with …
The generation of large numbers of functional human hepatocytes for cell-based approaches to liver disease is an important and unmet …
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N. Saha SK, et al. Nature. 2014 Sep 4;513(7516):110-4. doi: 10.1038/nature13441. Epub 2014 Jul 2. Nature. 2014. PMID: 25043045 Free PMC article.
Correspondingly, genetically engineered mouse models expressing mutant IDH in the adult liver show an aberrant response to hepatic injury, characterized by HNF-4alpha silencing, impaired hepatocyte differentiation, and markedly elevated levels of cell proliferation. …
Correspondingly, genetically engineered mouse models expressing mutant IDH in the adult liver show an aberrant response to hep …
Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases.
Yeh MM, Bosch DE, Daoud SS. Yeh MM, et al. World J Gastroenterol. 2019 Aug 14;25(30):4074-4091. doi: 10.3748/wjg.v25.i30.4074. World J Gastroenterol. 2019. PMID: 31435165 Free PMC article. Review.
Hepatocyte nuclear factor 4-alpha (HNF4alpha) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4alpha is bes …
Hepatocyte nuclear factor 4-alpha (HNF4alpha) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription …
Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers.
Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Mordaunt CE, et al. Epigenetics Chromatin. 2019 Feb 1;12(1):10. doi: 10.1186/s13072-019-0255-z. Epigenetics Chromatin. 2019. PMID: 30709419 Free PMC article.
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters, and binding sites of liver developmental transcription factors, including Hepatocyte Nuclear Factor 4 alpha ( …
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active …
Conversion of mesenchymal stem cells into a canine hepatocyte-like cells by Foxa1 and Hnf4a.
Nitta S, Kusakari Y, Yamada Y, Kubo T, Neo S, Igarashi H, Hisasue M. Nitta S, et al. Regen Ther. 2020 Feb 20;14:165-176. doi: 10.1016/j.reth.2020.01.003. eCollection 2020 Jun. Regen Ther. 2020. PMID: 32123700 Free PMC article.
The establishment of iHep cell lines are needed to carry out liver transplants and assess liver toxicity in the rising number of dogs affected by liver disease. ...Canine iHep cells are expected to provide insights for the construction of liver models …
The establishment of iHep cell lines are needed to carry out liver transplants and assess liver toxicity in the rising number …
Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival.
Hang HL, Liu XY, Wang HT, Xu N, Bian JM, Zhang JJ, Xia L, Xia Q. Hang HL, et al. Exp Cell Res. 2017 Nov 15;360(2):81-93. doi: 10.1016/j.yexcr.2017.08.020. Epub 2017 Sep 6. Exp Cell Res. 2017. PMID: 28870599
This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A) in hepatic differentiation of IHH, and whether encapsulation of IHH overexpressing HNF4A could improve liver function and survival in rats with acute liver failure (ALF). .. …
This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A) in hepatic differentiation of IHH, and whether encapsu …
140 results