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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 1
1998 3
2000 1
2001 2
2002 3
2003 3
2004 4
2005 5
2006 8
2007 8
2008 6
2009 7
2010 8
2011 6
2012 6
2013 9
2014 12
2015 6
2016 7
2017 7
2018 12
2019 9
2020 6
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Page 1
Maturity-onset diabetes of the young (MODY): an update.
Anık A, Çatlı G, Abacı A, Böber E. Anık A, et al. J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):251-63. doi: 10.1515/jpem-2014-0384. J Pediatr Endocrinol Metab. 2015. PMID: 25581748 Review.
However, mutations in the HNF1A and HNF4A cause a progressive pancreatic β-cell dysfunction and hyperglycemia that can result in microvascular complications. ...Mutations in the HNF1B (MODY 5) is associated with pancreatic agenesis, renal abnormalities, genital tract malfo …
However, mutations in the HNF1A and HNF4A cause a progressive pancreatic β-cell dysfunction and hyperglycemia that can result in micr …
Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers.
Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Mordaunt CE, et al. Epigenetics Chromatin. 2019 Feb 1;12(1):10. doi: 10.1186/s13072-019-0255-z. Epigenetics Chromatin. 2019. PMID: 30709419 Free PMC article.
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters, and binding sites of liver developmental transcription factors, including Hepatocyte Nuclear Factor 4 alpha ( …
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active …
circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.
Zhang X, Xu Y, Qian Z, Zheng W, Wu Q, Chen Y, Zhu G, Liu Y, Bian Z, Xu W, Zhang Y, Sun F, Pan Q, Wang J, Du L, Yu Y. Zhang X, et al. Cell Death Dis. 2018 Oct 25;9(11):1091. doi: 10.1038/s41419-018-1132-6. Cell Death Dis. 2018. PMID: 30361504 Free PMC article.
Mechanistically, HNF4a bound to the -1409 to -1401 region of the circ_104075 promoter to stimulate the expression of circ_104075. ...
Mechanistically, HNF4a bound to the -1409 to -1401 region of the circ_104075 promoter to stimulate the expression of circ_104075. ...
Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases.
Yeh MM, Bosch DE, Daoud SS. Yeh MM, et al. World J Gastroenterol. 2019 Aug 14;25(30):4074-4091. doi: 10.3748/wjg.v25.i30.4074. World J Gastroenterol. 2019. PMID: 31435165 Free PMC article. Review.
In liver, HNF4α is best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function. Dysregulation of HNF4α expression has been associated with many human diseases such as ulcerative colit …
In liver, HNF4α is best known for its role as a master regulator of liver-specific gene expression and essential for adult
H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses.
Deng J, Mueller M, Geng T, Shen Y, Liu Y, Hou P, Mamillapalli R, Taylor HS, Paidas M, Huang Y. Deng J, et al. Cell Death Dis. 2017 Dec 7;8(12):e3175. doi: 10.1038/cddis.2017.392. Cell Death Dis. 2017. PMID: 29215608 Free PMC article.
Mechanistically, we show that the methylation change of Hnf4α is induced by H19-mediated regulation of S-adenosylhomocysteine hydrolase. We also provide evidence that altered H19 expression is a direct effect of metformin in the fetal liver. Our results suggest that …
Mechanistically, we show that the methylation change of Hnf4α is induced by H19-mediated regulation of S-adenosylhomocysteine hydrola …
Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism.
Ibrahim S, Dayoub R, Krautbauer S, Liebisch G, Wege AK, Melter M, Weiss TS. Ibrahim S, et al. Exp Cell Res. 2019 Jan 1;374(1):189-197. doi: 10.1016/j.yexcr.2018.11.023. Epub 2018 Nov 28. Exp Cell Res. 2019. PMID: 30500391
Cholestasis represents pathophysiologic syndromes defined as an impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocytes injury followed by liver cirrhosis and liver failure. ...In this study we aimed to investigate the …
Cholestasis represents pathophysiologic syndromes defined as an impaired bile flow from the liver. As an outcome, bile acids accumula …
Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4α.
Guo S, Lu H. Guo S, et al. J Cell Biochem. 2019 Jan;120(1):519-532. doi: 10.1002/jcb.27407. Epub 2018 Sep 7. J Cell Biochem. 2019. PMID: 30191603
The HNF4A gene uses two separate promoters P1 and P2, with P1 products predominant in adult liver, whereas P2 products prevalent in fetal liver, pancreas, and liver/colon cancer. ...HNF4A-AS1, a long noncoding RNA, is localized between th …
The HNF4A gene uses two separate promoters P1 and P2, with P1 products predominant in adult liver, whereas P2 products …
Deregulation of the Genes that Are Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Hepatocellular Carcinoma.
Hu DG, Marri S, McKinnon RA, Mackenzie PI, Meech R. Hu DG, et al. J Pharmacol Exp Ther. 2019 Mar;368(3):363-381. doi: 10.1124/jpet.118.255018. Epub 2018 Dec 21. J Pharmacol Exp Ther. 2019. PMID: 30578287
ADME genes are highly expressed in the liver and their levels can be influenced by liver diseases such as hepatocellular carcinoma (HCC). ...In addition, about one-half of the core ADME genes were positively correlated with each other and were also positively (AHR, …
ADME genes are highly expressed in the liver and their levels can be influenced by liver diseases such as hepatocellular carci …
Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival.
Hang HL, Liu XY, Wang HT, Xu N, Bian JM, Zhang JJ, Xia L, Xia Q. Hang HL, et al. Exp Cell Res. 2017 Nov 15;360(2):81-93. doi: 10.1016/j.yexcr.2017.08.020. Epub 2017 Sep 6. Exp Cell Res. 2017. PMID: 28870599
This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A) in hepatic differentiation of IHH, and whether encapsulation of IHH overexpressing HNF4A could improve liver function and survival in rats with acute liver failure (ALF). .. …
This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A) in hepatic differentiation of IHH, and whether encapsu …
The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation.
Sartor C, Bachelot L, Godard C, Lager F, Renault G, Gonzalez FJ, Perret C, Gougelet A, Colnot S. Sartor C, et al. Liver Int. 2019 Apr;39(4):727-739. doi: 10.1111/liv.14068. Epub 2019 Feb 24. Liver Int. 2019. PMID: 30721564 Free PMC article.
BACKGROUND & AIMS: Loss of hepatocyte nuclear factor-4α (HNF4α), a critical factor driving liver development and differentiation, is frequently associated with hepatocellular carcinoma (HCC). ...METHODS: We generated a Hnf4a(flox/flox/) Apc(flox/flox) /TTR-Cre(E …
BACKGROUND & AIMS: Loss of hepatocyte nuclear factor-4α (HNF4α), a critical factor driving liver development and differentiation, …
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