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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 4
1996 4
1997 3
1998 4
1999 1
2000 3
2001 5
2002 5
2003 5
2004 8
2005 8
2006 14
2007 15
2008 12
2009 10
2010 9
2011 10
2012 8
2013 13
2014 16
2015 8
2016 8
2017 10
2018 14
2019 15
2020 18
2021 9
2022 7
2023 6
2024 7
2025 5

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235 results

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Page 1
Maturity-onset diabetes of the young (MODY): an update.
Anık A, Çatlı G, Abacı A, Böber E. Anık A, et al. J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):251-63. doi: 10.1515/jpem-2014-0384. J Pediatr Endocrinol Metab. 2015. PMID: 25581748 Review.
GCK mutations cause a mild, asymptomatic, and stable fasting hyperglycemia usually requiring no specific treatment. However, mutations in the HNF1A and HNF4A cause a progressive pancreatic beta-cell dysfunction and hyperglycemia that can result in microvascular complicatio …
GCK mutations cause a mild, asymptomatic, and stable fasting hyperglycemia usually requiring no specific treatment. However, mutations in th …
Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma.
Montal R, Sia D, Montironi C, Leow WQ, Esteban-Fabró R, Pinyol R, Torres-Martin M, Bassaganyas L, Moeini A, Peix J, Cabellos L, Maeda M, Villacorta-Martin C, Tabrizian P, Rodriguez-Carunchio L, Castellano G, Sempoux C, Minguez B, Pawlik TM, Labgaa I, Roberts LR, Sole M, Fiel MI, Thung S, Fuster J, Roayaie S, Villanueva A, Schwartz M, Llovet JM. Montal R, et al. J Hepatol. 2020 Aug;73(2):315-327. doi: 10.1016/j.jhep.2020.03.008. Epub 2020 Mar 12. J Hepatol. 2020. PMID: 32173382 Free PMC article.
Tumors classified within the Metabolic class (19%) showed a hepatocyte-like phenotype with activation of the transcription factor HNF4A and enrichment in gene signatures related to bile acid metabolism. The Proliferation class (23%), more common in patients with distal CCA …
Tumors classified within the Metabolic class (19%) showed a hepatocyte-like phenotype with activation of the transcription factor HNF4A …
Mettl3-mediated mRNA m(6)A modification controls postnatal liver development by modulating the transcription factor Hnf4a.
Xu Y, Zhou Z, Kang X, Pan L, Liu C, Liang X, Chu J, Dong S, Li Y, Liu Q, Sun Y, Yu S, Zhang Q. Xu Y, et al. Nat Commun. 2022 Aug 5;13(1):4555. doi: 10.1038/s41467-022-32169-4. Nat Commun. 2022. PMID: 35931692 Free PMC article.
Deleting Mettl3 reduces m(6)A modification on Hnf4a, decreases its transcript stability in an Igf2bp1-dependent manner, and down-regulates Hnf4a expression, while overexpressing Hnf4a with AAV8 alleviates the liver injury and prolongs the lifespan of M …
Deleting Mettl3 reduces m(6)A modification on Hnf4a, decreases its transcript stability in an Igf2bp1-dependent manner, and down-regu …
Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease.
Clotet-Freixas S, Zaslaver O, Kotlyar M, Pastrello C, Quaile AT, McEvoy CM, Saha AD, Farkona S, Boshart A, Zorcic K, Neupane S, Manion K, Allen M, Chan M, Chen X, Arnold AP, Sekula P, Steinbrenner I, Köttgen A, Dart AB, Wicklow B, McGavock JM, Blydt-Hansen TD, Barrios C, Riera M, Soler MJ, Isenbrandt A, Lamontagne-Proulx J, Pradeloux S, Coulombe K, Soulet D, Rajasekar S, Zhang B, John R, Mehrotra A, Gehring A, Puhka M, Jurisica I, Woo M, Scholey JW, Röst H, Konvalinka A. Clotet-Freixas S, et al. Sci Transl Med. 2024 Mar 6;16(737):eabm2090. doi: 10.1126/scitranslmed.abm2090. Epub 2024 Mar 6. Sci Transl Med. 2024. PMID: 38446901
The male human PTEC phenotype was enhanced by dihydrotestosterone and mediated by the transcription factor HNF4A and histone demethylase KDM6A. In mice where sex chromosomes either matched or did not match gonadal sex, male gonadal sex contributed to the kidney metabolism …
The male human PTEC phenotype was enhanced by dihydrotestosterone and mediated by the transcription factor HNF4A and histone demethyl …
HNF4α in Hepatocyte Health and Disease.
Kotulkar M, Robarts DR, Apte U. Kotulkar M, et al. Semin Liver Dis. 2023 May;43(2):234-244. doi: 10.1055/a-2097-0660. Epub 2023 May 22. Semin Liver Dis. 2023. PMID: 37216979 Free PMC article. Review.
Hepatocyte nuclear factor 4 alpha (HNF4alpha) is a highly conserved member of the nuclear receptor superfamily expressed at high levels in the liver, kidney, pancreas, and gut. In the liver, HNF4alpha is exclusively expressed in hepatocyt …
Hepatocyte nuclear factor 4 alpha (HNF4alpha) is a highly conserved member of the nuclear receptor superfamily e …
HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA.
Jia W, Yu L, Xu B, Feng Y, Wang J, Zhu D, Xu C, Liang L, Zhou Y, Kong L, Ding W. Jia W, et al. Int J Biol Sci. 2024 Sep 23;20(13):5087-5108. doi: 10.7150/ijbs.95276. eCollection 2024. Int J Biol Sci. 2024. PMID: 39430249 Free PMC article.
Subsequent in vitro and in vivo functional studies demonstrated that HNF4A-AS1 inhibits the proliferation, invasion, and stemness of HCC cells. Mechanistically, it was observed that HNF4A-AS1 physically interacts with the KH3 domain of PCBP2 through a specific segme …
Subsequent in vitro and in vivo functional studies demonstrated that HNF4A-AS1 inhibits the proliferation, invasion, and stemness of …
Hepatogenic Potential and Liver Regeneration Effect of Human Liver-derived Mesenchymal-Like Stem Cells.
Lee J, Choi J, Kang S, Kim J, Lee R, So S, Yoon YI, Kirchner VA, Song GW, Hwang S, Lee SG, Kang E, Tak E. Lee J, et al. Cells. 2020 Jun 22;9(6):1521. doi: 10.3390/cells9061521. Cells. 2020. PMID: 32580448 Free PMC article.
Human liver-derived stem cells (hLD-SCs) have been proposed as a possible resource for stem cell therapy in patients with irreversible liver diseases. ...Moreover, hLD-SCs featured higher numbers of hepatic progenitor cell markers on day 14 of differentiation (CPM a …
Human liver-derived stem cells (hLD-SCs) have been proposed as a possible resource for stem cell therapy in patients with irreversibl …
Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases.
Yeh MM, Bosch DE, Daoud SS. Yeh MM, et al. World J Gastroenterol. 2019 Aug 14;25(30):4074-4091. doi: 10.3748/wjg.v25.i30.4074. World J Gastroenterol. 2019. PMID: 31435165 Free PMC article. Review.
Hepatocyte nuclear factor 4-alpha (HNF4alpha) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In …
Hepatocyte nuclear factor 4-alpha (HNF4alpha) is a highly conserved member of nuclear receptor superfamily of li …
Isolation and characterization of adult human liver progenitors from ischemic liver tissue derived from therapeutic hepatectomies.
Stachelscheid H, Urbaniak T, Ring A, Spengler B, Gerlach JC, Zeilinger K. Stachelscheid H, et al. Tissue Eng Part A. 2009 Jul;15(7):1633-43. doi: 10.1089/ten.tea.2008.0291. Tissue Eng Part A. 2009. PMID: 19108677
To study the ischemic resistance of adult liver progenitors, we characterized remaining viable cells in human liver tissue after cold ischemic treatment for 24-168 h, applied to the tissue before cell isolation. ...The cells expressed epithelial cell adhesion …
To study the ischemic resistance of adult liver progenitors, we characterized remaining viable cells in human liver tis …
Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.
Huang P, Zhang L, Gao Y, He Z, Yao D, Wu Z, Cen J, Chen X, Liu C, Hu Y, Lai D, Hu Z, Chen L, Zhang Y, Cheng X, Ma X, Pan G, Wang X, Hui L. Huang P, et al. Cell Stem Cell. 2014 Mar 6;14(3):370-84. doi: 10.1016/j.stem.2014.01.003. Epub 2014 Feb 27. Cell Stem Cell. 2014. PMID: 24582927 Free article.
The generation of large numbers of functional human hepatocytes for cell-based approaches to liver disease is an important and unmet goal. Direct reprogramming of fibroblasts to hepatic lineages could offer a solution to this problem but so far has only been achieved with …
The generation of large numbers of functional human hepatocytes for cell-based approaches to liver disease is an important and unmet …
235 results