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1995 1
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2006 12
2007 6
2008 7
2009 4
2010 2
2011 1
2012 5
2013 5
2014 4
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2016 5
2017 7
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2019 4
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2022 12
2023 7

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Page 1
Ex vivo infection model for Francisella using human lung tissue.
Köppen K, Fatykhova D, Holland G, Rauch J, Tappe D, Graff M, Rydzewski K, Hocke AC, Hippenstiel S, Heuner K. Köppen K, et al. Among authors: hocke ac. Front Cell Infect Microbiol. 2023 Jul 10;13:1224356. doi: 10.3389/fcimb.2023.1224356. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37492528 Free PMC article.
The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment.
Timm S, Lettau M, Hegermann J, Rocha ML, Weidenfeld S, Fatykhova D, Gutbier B, Nouailles G, Lopez-Rodriguez E, Hocke A, Hippenstiel S, Witzenrath M, Kuebler WM, Ochs M. Timm S, et al. Among authors: hocke a. Histochem Cell Biol. 2023 Aug;160(2):83-96. doi: 10.1007/s00418-023-02211-7. Epub 2023 Jun 29. Histochem Cell Biol. 2023. PMID: 37386200 Free PMC article.
Dual-Action Heteromultivalent Glycopolymers Stringently Block and Arrest Influenza A Virus Infection In Vitro and Ex Vivo.
Parshad B, Schlecht MN, Baumgardt M, Ludwig K, Nie C, Rimondi A, Hönzke K, Angioletti-Uberti S, Khatri V, Schneider P, Herrmann A, Haag R, Hocke AC, Wolff T, Bhatia S. Parshad B, et al. Among authors: hocke ac. Nano Lett. 2023 Jun 14;23(11):4844-4853. doi: 10.1021/acs.nanolett.3c00408. Epub 2023 May 23. Nano Lett. 2023. PMID: 37220024
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19.
Mothes R, Pascual-Reguant A, Koehler R, Liebeskind J, Liebheit A, Bauherr S, Philipsen L, Dittmayer C, Laue M, von Manitius R, Elezkurtaj S, Durek P, Heinrich F, Heinz GA, Guerra GM, Obermayer B, Meinhardt J, Ihlow J, Radke J, Heppner FL, Enghard P, Stockmann H, Aschman T, Schneider J, Corman VM, Sander LE, Mashreghi MF, Conrad T, Hocke AC, Niesner RA, Radbruch H, Hauser AE. Mothes R, et al. Among authors: hocke ac. Nat Commun. 2023 Feb 11;14(1):791. doi: 10.1038/s41467-023-36333-2. Nat Commun. 2023. PMID: 36774347 Free PMC article.
State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt M, Hülsemann M, Löwa A, Fatykhova D, Hoffmann K, Kessler M, Mieth M, Hellwig K, Frey D, Langenhagen A, Voss A, Obermayer B, Wyler E, Dökel S, Gruber AD, Tölch U, Hippenstiel S, Hocke AC, Hönzke K. Baumgardt M, et al. Among authors: hocke ac. PLoS One. 2022 Dec 20;17(12):e0276115. doi: 10.1371/journal.pone.0276115. eCollection 2022. PLoS One. 2022. PMID: 36538516 Free PMC article.
Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM. Erfinanda L, et al. Among authors: hocke a. Sci Transl Med. 2022 Dec 7;14(674):eabg8577. doi: 10.1126/scitranslmed.abg8577. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475904
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus.
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC. Bertrams W, et al. Among authors: hocke ac. Sci Rep. 2022 Nov 29;12(1):20608. doi: 10.1038/s41598-022-24792-4. Sci Rep. 2022. PMID: 36446841 Free PMC article.
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L. Faist A, et al. Among authors: hocke a. Antiviral Res. 2023 Jan;209:105475. doi: 10.1016/j.antiviral.2022.105475. Epub 2022 Nov 21. Antiviral Res. 2023. PMID: 36423831 Free PMC article.
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C. Niemeyer D, et al. Among authors: hocke ac. PLoS Biol. 2022 Nov 16;20(11):e3001871. doi: 10.1371/journal.pbio.3001871. eCollection 2022 Nov. PLoS Biol. 2022. PMID: 36383605 Free PMC article.
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze C, Kocks C, Leiz J, Karaiskos N, Boltengagen A, Cao S, Skopnik CM, Klocke J, Hardenberg JH, Stockmann H, Gotthardt I, Obermayer B, Haghverdi L, Wyler E, Landthaler M, Bachmann S, Hocke AC, Corman V, Busch J, Schneider W, Himmerkus N, Bleich M, Eckardt KU, Enghard P, Rajewsky N, Schmidt-Ott KM. Hinze C, et al. Among authors: hocke ac. Genome Med. 2022 Sep 9;14(1):103. doi: 10.1186/s13073-022-01108-9. Genome Med. 2022. PMID: 36085050 Free PMC article.
Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M. Hoffmann K, et al. Among authors: hocke ac. Commun Biol. 2022 Aug 25;5(1):875. doi: 10.1038/s42003-022-03828-5. Commun Biol. 2022. PMID: 36008580 Free PMC article.
Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses.
Krasemann S, Dittmayer C, von Stillfried S, Meinhardt J, Heinrich F, Hartmann K, Pfefferle S, Thies E, von Manitius R, Aschman TAD, Radke J, Osterloh A, Schmid S, Buhl EM, Ihlow J, Dubois F, Arnhold V, Elezkurtaj S, Horst D, Hocke A, Timm S, Bachmann S, Corman V, Goebel HH, Matschke J, Stanelle-Bertram S, Gabriel G, Seilhean D, Adle-Biassette H, Ondruschka B, Ochs M, Stenzel W, Heppner FL, Boor P, Radbruch H, Laue M, Glatzel M. Krasemann S, et al. Among authors: hocke a. EBioMedicine. 2022 Sep;83:104193. doi: 10.1016/j.ebiom.2022.104193. Epub 2022 Aug 2. EBioMedicine. 2022. PMID: 35930888 Free PMC article.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G. Pennitz P, et al. Among authors: hocke ac. Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. Print 2022 Sep 30. Eur Respir Rev. 2022. PMID: 35896273 Free PMC article. Review.
Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research: Lessons and recommendation from implementing an ad hoc quality management system for organ model research.
Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U. Hülsemann M, et al. Among authors: hocke ac. EMBO Rep. 2022 Aug 3;23(8):e55095. doi: 10.15252/embr.202255095. Epub 2022 Jul 25. EMBO Rep. 2022. PMID: 35876564 Free PMC article.
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fatykhova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC. Hönzke K, et al. Among authors: hocke ac. Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021. Print 2022 Dec. Eur Respir J. 2022. PMID: 35728978 Free PMC article.
Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection.
Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M. Wienhold SM, et al. Among authors: hocke ac. Viruses. 2021 Dec 24;14(1):33. doi: 10.3390/v14010033. Viruses. 2021. PMID: 35062236 Free PMC article.
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI); Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE. Wendisch D, et al. Among authors: hocke a. Cell. 2021 Dec 22;184(26):6243-6261.e27. doi: 10.1016/j.cell.2021.11.033. Epub 2021 Nov 27. Cell. 2021. PMID: 34914922 Free PMC article.
Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant Viruses.
Schulze J, Mache C, Balázs A, Frey D, Niemeyer D, Olze H, Dommerich S, Drosten C, Hocke AC, Mall MA, Hippenstiel S, Wolff T. Schulze J, et al. Among authors: hocke ac. J Infect Dis. 2021 Dec 15;224(12):2020-2024. doi: 10.1093/infdis/jiab523. J Infect Dis. 2021. PMID: 34651643 Free PMC article.
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.
Schroeder S, Mache C, Kleine-Weber H, Corman VM, Muth D, Richter A, Fatykhova D, Memish ZA, Stanifer ML, Boulant S, Gultom M, Dijkman R, Eggeling S, Hocke A, Hippenstiel S, Thiel V, Pöhlmann S, Wolff T, Müller MA, Drosten C. Schroeder S, et al. Among authors: hocke a. Nat Commun. 2021 Sep 7;12(1):5324. doi: 10.1038/s41467-021-25519-1. Nat Commun. 2021. PMID: 34493730 Free PMC article.
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.
Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C. Loyal L, et al. Among authors: hocke a. Science. 2021 Oct 8;374(6564):eabh1823. doi: 10.1126/science.abh1823. Epub 2021 Oct 8. Science. 2021. PMID: 34465633 Free PMC article.
Patient participation in multidisciplinary tumor conferences: How is it implemented? What is the patients' role? What are patients' experiences?
Ansmann L, Heuser C, Diekmann A, Schellenberger B, Biehl C, Danaei M, Eichler C, Heinz D, Hocke A, Malter W, Melekian B, Metin H, Mustea A, Palatty J, Peisker U, Petschat I, Ernstmann N. Ansmann L, et al. Among authors: hocke a. Cancer Med. 2021 Oct;10(19):6714-6724. doi: 10.1002/cam4.4213. Epub 2021 Aug 17. Cancer Med. 2021. PMID: 34402196 Free PMC article.
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Gassen NC, Papies J, Bajaj T, Emanuel J, Dethloff F, Chua RL, Trimpert J, Heinemann N, Niemeyer C, Weege F, Hönzke K, Aschman T, Heinz DE, Weckmann K, Ebert T, Zellner A, Lennarz M, Wyler E, Schroeder S, Richter A, Niemeyer D, Hoffmann K, Meyer TF, Heppner FL, Corman VM, Landthaler M, Hocke AC, Morkel M, Osterrieder N, Conrad C, Eils R, Radbruch H, Giavalisco P, Drosten C, Müller MA. Gassen NC, et al. Among authors: hocke ac. Nat Commun. 2021 Jun 21;12(1):3818. doi: 10.1038/s41467-021-24007-w. Nat Commun. 2021. PMID: 34155207 Free PMC article.
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study.
Thibeault C, Mühlemann B, Helbig ET, Mittermaier M, Lingscheid T, Tober-Lau P, Meyer-Arndt LA, Meiners L, Stubbemann P, Haenel SS, Bosquillon de Jarcy L, Lippert L, Pfeiffer M, Stegemann MS, Roehle R, Wiebach J, Hippenstiel S, Zoller T, Müller-Redetzky H, Uhrig A, Balzer F, von Kalle C, Suttorp N, Jones TC, Drosten C, Witzenrath M, Sander LE; Pa-COVID Study Group; Corman VM, Kurth F. Thibeault C, et al. Infection. 2021 Aug;49(4):703-714. doi: 10.1007/s15010-021-01594-w. Epub 2021 Apr 22. Infection. 2021. PMID: 33890243 Free PMC article.
COVID-19 highlights the model dilemma in biomedical research.
Adhikary PP, Ul Ain Q, Hocke AC, Hedtrich S. Adhikary PP, et al. Among authors: hocke ac. Nat Rev Mater. 2021;6(5):374-376. doi: 10.1038/s41578-021-00305-z. Epub 2021 Mar 17. Nat Rev Mater. 2021. PMID: 33747552 Free PMC article.
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler E, Mösbauer K, Franke V, Diag A, Gottula LT, Arsiè R, Klironomos F, Koppstein D, Hönzke K, Ayoub S, Buccitelli C, Hoffmann K, Richter A, Legnini I, Ivanov A, Mari T, Del Giudice S, Papies J, Praktiknjo S, Meyer TF, Müller MA, Niemeyer D, Hocke A, Selbach M, Akalin A, Rajewsky N, Drosten C, Landthaler M. Wyler E, et al. Among authors: hocke a. iScience. 2021 Mar 19;24(3):102151. doi: 10.1016/j.isci.2021.102151. Epub 2021 Feb 6. iScience. 2021. PMID: 33585804 Free PMC article.
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure.
Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM. Michalick L, et al. Among authors: hocke ac. Eur Respir J. 2021 Mar 11;57(3):2002384. doi: 10.1183/13993003.02384-2020. Print 2021 Mar. Eur Respir J. 2021. PMID: 33154030 Free PMC article.
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.
Kreye J, Reincke SM, Kornau HC, Sánchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Höltje M, Dietert K, Stöffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Müller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Prüss H. Kreye J, et al. Among authors: hocke ac. Cell. 2020 Nov 12;183(4):1058-1069.e19. doi: 10.1016/j.cell.2020.09.049. Epub 2020 Sep 23. Cell. 2020. PMID: 33058755 Free PMC article.
A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model.
Kreye J, Reincke SM, Kornau HC, Sánchez-Sendin E, Max Corman V, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Höltje M, Dietert K, Stöffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Müller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Prüss H. Kreye J, et al. Among authors: hocke ac. bioRxiv. 2020 Aug 16:2020.08.15.252320. doi: 10.1101/2020.08.15.252320. Preprint. bioRxiv. 2020. PMID: 32817952 Free PMC article. Updated.
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE; Deutsche COVID-19 OMICS Initiative (DeCOI). Schulte-Schrepping J, et al. Among authors: hocke a. Cell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001. Epub 2020 Aug 5. Cell. 2020. PMID: 32810438 Free PMC article.
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19.
Braun J, Loyal L, Frentsch M, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A. Braun J, et al. Among authors: hocke a. Nature. 2020 Nov;587(7833):270-274. doi: 10.1038/s41586-020-2598-9. Epub 2020 Jul 29. Nature. 2020. PMID: 32726801
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.
Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M. Messner CB, et al. Among authors: hocke a. Cell Syst. 2020 Jul 22;11(1):11-24.e4. doi: 10.1016/j.cels.2020.05.012. Epub 2020 Jun 2. Cell Syst. 2020. PMID: 32619549 Free PMC article.
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R. Chua RL, et al. Among authors: hocke a. Nat Biotechnol. 2020 Aug;38(8):970-979. doi: 10.1038/s41587-020-0602-4. Epub 2020 Jun 26. Nat Biotechnol. 2020. PMID: 32591762
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE. Kurth F, et al. Among authors: hocke a. Infection. 2020 Aug;48(4):619-626. doi: 10.1007/s15010-020-01464-x. Epub 2020 Jun 13. Infection. 2020. PMID: 32535877 Free PMC article.
Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry.
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Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Hönzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S, Brunotte L. Matos ADR, et al. Among authors: hocke a. Emerg Microbes Infect. 2019;8(1):1763-1776. doi: 10.1080/22221751.2019.1698271. Emerg Microbes Infect. 2019. PMID: 31826721 Free PMC article.
Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study.
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Generation of a 3D Liver Model Comprising Human Extracellular Matrix in an Alginate/Gelatin-Based Bioink by Extrusion Bioprinting for Infection and Transduction Studies.
Hiller T, Berg J, Elomaa L, Röhrs V, Ullah I, Schaar K, Dietrich AC, Al-Zeer MA, Kurtz A, Hocke AC, Hippenstiel S, Fechner H, Weinhart M, Kurreck J. Hiller T, et al. Among authors: hocke ac. Int J Mol Sci. 2018 Oct 12;19(10):3129. doi: 10.3390/ijms19103129. Int J Mol Sci. 2018. PMID: 30321994 Free PMC article.
Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.
Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M. Zakrzewicz D, et al. Among authors: hocke ac. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1816-1827. doi: 10.1016/j.bbadis.2018.02.021. Epub 2018 Mar 2. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29501774 Free article.
Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia.
Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD. Dietert K, et al. Among authors: hocke ac. Am J Respir Cell Mol Biol. 2018 Apr;58(4):440-448. doi: 10.1165/rcmb.2017-0337MA. Am J Respir Cell Mol Biol. 2018. PMID: 29361238
A comparative analysis of human bone marrow-resident and peripheral memory B cells.
Becker SC, Szyska M, Mensen A, Hellwig K, Otto R, Olfe L, Volk HD, Dörner T, Dörken B, Scheibenbogen C, Schröder J, Hocke AC, Na IK. Becker SC, et al. Among authors: hocke ac. J Allergy Clin Immunol. 2018 May;141(5):1911-1913.e7. doi: 10.1016/j.jaci.2017.12.983. Epub 2018 Jan 31. J Allergy Clin Immunol. 2018. PMID: 29355676 No abstract available.
Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.
Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Imai-Matsushima A, Meyer TF, Paasch L, Mitchell TJ, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC. Nerlich A, et al. Among authors: hocke ac. Sci Rep. 2018 Jan 9;8(1):182. doi: 10.1038/s41598-017-18468-7. Sci Rep. 2018. PMID: 29317705 Free PMC article.
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
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Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.
Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD. Dietert K, et al. Among authors: hocke ac. PLoS One. 2017 Nov 20;12(11):e0188251. doi: 10.1371/journal.pone.0188251. eCollection 2017. PLoS One. 2017. PMID: 29155867 Free PMC article.
Human Pulmonary 3D Models For Translational Research.
Zscheppang K, Berg J, Hedtrich S, Verheyen L, Wagner DE, Suttorp N, Hippenstiel S, Hocke AC. Zscheppang K, et al. Among authors: hocke ac. Biotechnol J. 2018 Jan;13(1):1700341. doi: 10.1002/biot.201700341. Epub 2017 Sep 20. Biotechnol J. 2018. PMID: 28865134 Free PMC article. Review.
Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.
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Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer.
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Human lung ex vivo infection models.
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Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.
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IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B. Naujoks J, et al. Among authors: hocke ac. PLoS Pathog. 2016 Feb 1;12(2):e1005408. doi: 10.1371/journal.ppat.1005408. eCollection 2016 Feb. PLoS Pathog. 2016. PMID: 26829557 Free PMC article.
Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): a double-blind, randomised controlled trial.
Forbes JF, Sestak I, Howell A, Bonanni B, Bundred N, Levy C, von Minckwitz G, Eiermann W, Neven P, Stierer M, Holcombe C, Coleman RE, Jones L, Ellis I, Cuzick J; IBIS-II investigators. Forbes JF, et al. Lancet. 2016 Feb 27;387(10021):866-73. doi: 10.1016/S0140-6736(15)01129-0. Epub 2015 Dec 11. Lancet. 2016. PMID: 26686313 Free PMC article. Clinical Trial.
Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.
Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B. Fatykhova D, et al. Among authors: hocke ac. PLoS One. 2015 Aug 28;10(8):e0137108. doi: 10.1371/journal.pone.0137108. eCollection 2015. PLoS One. 2015. PMID: 26317436 Free PMC article.
CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.
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Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AD, Kershaw O, Mayer K, Suttorp N, Witzenrath M. Müller-Redetzky HC, et al. Among authors: hocke ac. J Antimicrob Chemother. 2015 Mar;70(3):830-40. doi: 10.1093/jac/dku446. Epub 2014 Nov 17. J Antimicrob Chemother. 2015. PMID: 25406299
Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs.
Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T. Hocke AC, et al. Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-6. doi: 10.1164/rccm.201305-0954LE. Am J Respir Crit Care Med. 2013. PMID: 24083868 No abstract available.
Reply to Fujino et al.
Hocke AC, Berg J, Becher A, Knepper J, Klauschen F, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Hippenstiel S, Wolff T. Hocke AC, et al. J Infect Dis. 2013 Feb 15;207(4):693-5. doi: 10.1093/infdis/jis740. Epub 2012 Nov 29. J Infect Dis. 2013. PMID: 23204172 No abstract available.
Influenza A viruses target type II pneumocytes in the human lung.
Weinheimer VK, Becher A, Tönnies M, Holland G, Knepper J, Bauer TT, Schneider P, Neudecker J, Rückert JC, Szymanski K, Temmesfeld-Wollbrueck B, Gruber AD, Bannert N, Suttorp N, Hippenstiel S, Wolff T, Hocke AC. Weinheimer VK, et al. Among authors: hocke ac. J Infect Dis. 2012 Dec 1;206(11):1685-94. doi: 10.1093/infdis/jis455. Epub 2012 Jul 24. J Infect Dis. 2012. PMID: 22829640 Free PMC article.
Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue.
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The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.
Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N'Guessan PD, Rosseau S, Suttorp N, Witzenrath M. Müller HC, et al. Among authors: hocke ac. Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23. Pulm Pharmacol Ther. 2011. PMID: 21419858
Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells.
Buss C, Opitz B, Hocke AC, Lippmann J, van Laak V, Hippenstiel S, Krüll M, Suttorp N, Eitel J. Buss C, et al. Among authors: hocke ac. J Immunol. 2010 Mar 15;184(6):3072-8. doi: 10.4049/jimmunol.0902947. Epub 2010 Feb 12. J Immunol. 2010. PMID: 20154210
Adrenomedullin reduces intestinal epithelial permeability in vivo and in vitro.
Temmesfeld-Wollbrück B, Brell B, zu Dohna C, Dorenberg M, Hocke AC, Martens H, Klar J, Suttorp N, Hippenstiel S. Temmesfeld-Wollbrück B, et al. Among authors: hocke ac. Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G43-51. doi: 10.1152/ajpgi.90532.2008. Epub 2009 May 7. Am J Physiol Gastrointest Liver Physiol. 2009. PMID: 19423749 Free article.
Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.
Dje N'Guessan P, Riediger F, Vardarova K, Scharf S, Eitel J, Opitz B, Slevogt H, Weichert W, Hocke AC, Schmeck B, Suttorp N, Hippenstiel S. Dje N'Guessan P, et al. Among authors: hocke ac. Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):380-6. doi: 10.1161/ATVBAHA.108.178319. Epub 2009 Jan 2. Arterioscler Thromb Vasc Biol. 2009. PMID: 19122173
NAIP and Ipaf control Legionella pneumophila replication in human cells.
Vinzing M, Eitel J, Lippmann J, Hocke AC, Zahlten J, Slevogt H, N'guessan PD, Günther S, Schmeck B, Hippenstiel S, Flieger A, Suttorp N, Opitz B. Vinzing M, et al. Among authors: hocke ac. J Immunol. 2008 May 15;180(10):6808-15. doi: 10.4049/jimmunol.180.10.6808. J Immunol. 2008. PMID: 18453601
Adrenomedullin and endothelial barrier function.
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Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response.
Slevogt H, Seybold J, Tiwari KN, Hocke AC, Jonatat C, Dietel S, Hippenstiel S, Singer BB, Bachmann S, Suttorp N, Opitz B. Slevogt H, et al. Among authors: hocke ac. Cell Microbiol. 2007 Mar;9(3):694-707. doi: 10.1111/j.1462-5822.2006.00821.x. Epub 2006 Oct 18. Cell Microbiol. 2007. PMID: 17054439
Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium.
N'Guessan PD, Etouem MO, Schmeck B, Hocke AC, Scharf S, Vardarova K, Opitz B, Flieger A, Suttorp N, Hippenstiel S. N'Guessan PD, et al. Among authors: hocke ac. Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L267-77. doi: 10.1152/ajplung.00100.2006. Epub 2006 Sep 29. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 17012371 Free article.
Listeria monocytogenes induced Rac1-dependent signal transduction in endothelial cells.
Schmeck B, Beermann W, van Laak V, Opitz B, Hocke AC, Meixenberger K, Eitel J, Chakraborty T, Schmidt G, Barth H, Suttorp N, Hippenstiel S. Schmeck B, et al. Among authors: hocke ac. Biochem Pharmacol. 2006 Nov 30;72(11):1367-74. doi: 10.1016/j.bcp.2006.06.033. Epub 2006 Aug 1. Biochem Pharmacol. 2006. PMID: 16884694
Detection of allergen-induced airway hyperresponsiveness in isolated mouse lungs.
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Allergic lung inflammation induces pulmonary vascular hyperresponsiveness.
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Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells.
Schmeck B, Huber S, Moog K, Zahlten J, Hocke AC, Opitz B, Hammerschmidt S, Mitchell TJ, Kracht M, Rosseau S, Suttorp N, Hippenstiel S. Schmeck B, et al. Among authors: hocke ac. Am J Physiol Lung Cell Mol Physiol. 2006 Apr;290(4):L730-L737. doi: 10.1152/ajplung.00271.2005. Epub 2005 Nov 18. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16299055 Free article.
Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae.
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Porphyromonas gingivalis strain-dependent activation of human endothelial cells.
Walter C, Zahlten J, Schmeck B, Schaudinn C, Hippenstiel S, Frisch E, Hocke AC, Pischon N, Kuramitsu HK, Bernimoulin JP, Suttorp N, Krüll M. Walter C, et al. Among authors: hocke ac. Infect Immun. 2004 Oct;72(10):5910-8. doi: 10.1128/IAI.72.10.5910-5918.2004. Infect Immun. 2004. PMID: 15385493 Free PMC article.
Adrenomedullin reduces endothelial hyperpermeability.
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[Catamenial seizures--an analysis].
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