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Friend or enemy? Review of 17beta-HSD10 and its role in human health or disease.
Vinklarova L, Schmidt M, Benek O, Kuca K, Gunn-Moore F, Musilek K. Vinklarova L, et al. J Neurochem. 2020 Nov;155(3):231-249. doi: 10.1111/jnc.15027. Epub 2020 May 23. J Neurochem. 2020. PMID: 32306391 Free article. Review.
These roles therefore, indicate that 17beta-HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer's disease (AD), and in hormone-dependent cancer. The objective of this review was to provide a summary about physiological …
These roles therefore, indicate that 17beta-HSD10 may be a possible druggable target for neurodegenerative diseases including …
HSD10 disease: clinical consequences of mutations in the HSD17B10 gene.
Zschocke J. Zschocke J. J Inherit Metab Dis. 2012 Jan;35(1):81-9. doi: 10.1007/s10545-011-9415-4. Epub 2011 Nov 30. J Inherit Metab Dis. 2012. PMID: 22127393 Review.
HSD10 is required for normal mitochondrial maintenance, and complete loss of HSD10 is incompatible with life. Mutations in the HSD17B10 gene have been reported in 19 families. The classical infantile form of what is best named HSD10 disease is c
HSD10 is required for normal mitochondrial maintenance, and complete loss of HSD10 is incompatible with life. Mutations
Involvement of Type 10 17beta-Hydroxysteroid Dehydrogenase in the Pathogenesis of Infantile Neurodegeneration and Alzheimer's Disease.
He XY, Frackowiak J, Dobkin C, Brown WT, Yang SY. He XY, et al. Int J Mol Sci. 2023 Dec 18;24(24):17604. doi: 10.3390/ijms242417604. Int J Mol Sci. 2023. PMID: 38139430 Free PMC article. Review.
Deacetylation of 17beta-HSD10 by sirtuins helps regulate its catalytic activities. 17beta-HSD10 may also play a critical role in the control of mitochondrial structure, morphology and dynamics by acting as a member of the Parkin/PINK1 pathway, and by binding …
Deacetylation of 17beta-HSD10 by sirtuins helps regulate its catalytic activities. 17beta-HSD10 may also play a critical role …
Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders.
Yang SY, He XY, Isaacs C, Dobkin C, Miller D, Philipp M. Yang SY, et al. J Steroid Biochem Mol Biol. 2014 Sep;143:460-72. doi: 10.1016/j.jsbmb.2014.07.001. Epub 2014 Jul 5. J Steroid Biochem Mol Biol. 2014. PMID: 25007702 Free article. Review.
The brains of individuals with Alzheimer's disease (AD) and of animals in an AD mouse model exhibit abnormally elevated levels of 17beta-HSD10. ...This may underlie the pathogenesis of the synaptic and neuronal deficiency exhibited in 17beta-HSD10 related …
The brains of individuals with Alzheimer's disease (AD) and of animals in an AD mouse model exhibit abnormally elevated levels of 17b …
Hydroxysteroid (17beta) dehydrogenase X in human health and disease.
Yang SY, He XY, Miller D. Yang SY, et al. Mol Cell Endocrinol. 2011 Aug 22;343(1-2):1-6. doi: 10.1016/j.mce.2011.06.011. Epub 2011 Jun 25. Mol Cell Endocrinol. 2011. PMID: 21708223 Review.
Hydroxysteroid (17beta) dehydrogenase 10 (HSD10), the HSD17B10 gene product, is a mitochondrial NAD(+)-dependent dehydrogenase. ...The clinical condition of some HSD10 patients mimics mitochondrial disorders. Since normal HSD10 function is essen …
Hydroxysteroid (17beta) dehydrogenase 10 (HSD10), the HSD17B10 gene product, is a mitochondrial NAD(+)-dependent dehydrogenase …
Infantile Neurodegeneration Results from Mutants of 17β-Hydroxysteroid Dehydrogenase Type 10 Rather Than Aβ-Binding Alcohol Dehydrogenase.
He XY, Dobkin C, Brown WT, Yang SY. He XY, et al. Int J Mol Sci. 2023 May 9;24(10):8487. doi: 10.3390/ijms24108487. Int J Mol Sci. 2023. PMID: 37239833 Free PMC article. Review.
A 5-methylcytosine hotspot underlying a 388-T transition leads to the HSD10 (p.R130C) mutant to be responsible for approximately half of all cases suffering with this mitochondrial disease. ...Furthermore, the rediscovery of ABAD/ERAB's mitochondrial l …
A 5-methylcytosine hotspot underlying a 388-T transition leads to the HSD10 (p.R130C) mutant to be responsible for approximately half …
Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase.
Yang SY, He XY, Schulz H. Yang SY, et al. Trends Endocrinol Metab. 2005 May-Jun;16(4):167-75. doi: 10.1016/j.tem.2005.03.006. Trends Endocrinol Metab. 2005. PMID: 15860413 Review.
Human 17beta-hydroxysteroid dehydrogenase type 10 (17beta-HSD10) is a mitochondrial enzyme encoded by the SCHAD gene, which escapes chromosome X inactivation. 17Beta-HSD10/SCHAD mutations cause a spectrum of clinical conditions, from mild mental retardation t …
Human 17beta-hydroxysteroid dehydrogenase type 10 (17beta-HSD10) is a mitochondrial enzyme encoded by the SCHAD gene, which es …
17β-Hydroxysteroid dehydrogenases and neurosteroid metabolism in the central nervous system.
He XY, Dobkin C, Yang SY. He XY, et al. Mol Cell Endocrinol. 2019 Jun 1;489:92-97. doi: 10.1016/j.mce.2018.10.002. Epub 2018 Oct 13. Mol Cell Endocrinol. 2019. PMID: 30321584 Review.
Mutations identified in this gene resulted in two distinct brain diseases, namely HSD10 deficiency and MRXS10, of which clinical presentations and pathogenetic mechanisms are quite different. Since elevated levels of 17beta-HSD10 was found in brains of Alzhei …
Mutations identified in this gene resulted in two distinct brain diseases, namely HSD10 deficiency and MRXS10, of which clinic …
HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids.
Yang SY, He XY, Miller D. Yang SY, et al. Mol Genet Metab. 2007 Sep-Oct;92(1-2):36-42. doi: 10.1016/j.ymgme.2007.06.001. Epub 2007 Jul 6. Mol Genet Metab. 2007. PMID: 17618155 Review.
The HSD17B10 gene maps on chromosome Xp11.2, a region highly associated with X-linked mental retardation. This gene encodes HSD10, a mitochondrial multifunctional enzyme that plays a significant part in the metabolism of neuroactive steroids and the degradation of i …
The HSD17B10 gene maps on chromosome Xp11.2, a region highly associated with X-linked mental retardation. This gene encodes HSD10, a …
Roles of type 10 17beta-hydroxysteroid dehydrogenase in intracrinology and metabolism of isoleucine and fatty acids.
He XY, Yang SY. He XY, et al. Endocr Metab Immune Disord Drug Targets. 2006 Mar;6(1):95-102. doi: 10.2174/187153006776056639. Endocr Metab Immune Disord Drug Targets. 2006. PMID: 16611167 Review.
This mitochondrial dehydrogenase enables prostate cancer cells to generate 5alpha-DHT in the absence of testosterone. Its inactivation of allopregnanolone is important to the modulation of GABA(A) receptor. Among steroidogenic enzymes 17beta-HSD10 plays a significan …
This mitochondrial dehydrogenase enables prostate cancer cells to generate 5alpha-DHT in the absence of testosterone. Its inactivatio …