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The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.
Radtke S, Haan S, Jörissen A, Hermanns HM, Diefenbach S, Smyczek T, Schmitz-Vandeleur H, Heinrich PC, Behrmann I, Haan C. Radtke S, et al. Among authors: haan s, haan c. J Biol Chem. 2005 Jul 8;280(27):25760-8. doi: 10.1074/jbc.M500822200. Epub 2005 May 12. J Biol Chem. 2005. PMID: 15894543 Free article.
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase.
Behrmann I, Smyczek T, Heinrich PC, Schmitz-Van de Leur H, Komyod W, Giese B, Müller-Newen G, Haan S, Haan C. Behrmann I, et al. Among authors: haan s, haan c. J Biol Chem. 2004 Aug 20;279(34):35486-93. doi: 10.1074/jbc.M404202200. Epub 2004 May 3. J Biol Chem. 2004. PMID: 15123646 Free article.
204 results