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Facilitation of cognitive functions by a specific alpha2-adrenoceptor antagonist, atipamezole.
Haapalinna A, Sirviö J, Lammintausta R. Haapalinna A, et al. Eur J Pharmacol. 1998 Apr 17;347(1):29-40. doi: 10.1016/s0014-2999(98)00077-6. Eur J Pharmacol. 1998. PMID: 9650845
Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats.
Pitkänen A, Narkilahti S, Bezvenyuk Z, Haapalinna A, Nissinen J. Pitkänen A, et al. Among authors: haapalinna a. Epilepsy Res. 2004 Sep-Oct;61(1-3):119-40. doi: 10.1016/j.eplepsyres.2004.07.005. Epilepsy Res. 2004. PMID: 15451014
Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist.
Pertovaara A, Haapalinna A, Sirviö J, Virtanen R. Pertovaara A, et al. Among authors: haapalinna a. CNS Drug Rev. 2005 Autumn;11(3):273-88. doi: 10.1111/j.1527-3458.2005.tb00047.x. CNS Drug Rev. 2005. PMID: 16389294 Free PMC article. Review.
Levosimendan alone and in combination with valsartan prevents stroke in Dahl salt-sensitive rats.
Levijoki J, Kivikko M, Pollesello P, Sallinen J, Hyttilä-Hopponen M, Kuoppamäki M, Haasio K, Gröhn O, Miettinen R, Puoliväli J, Tähtivaara L, Yrjänheikki J, Haapalinna A. Levijoki J, et al. Among authors: haapalinna a. Eur J Pharmacol. 2015 Mar 5;750:132-40. doi: 10.1016/j.ejphar.2015.01.037. Epub 2015 Jan 29. Eur J Pharmacol. 2015. PMID: 25641751 Free article.
Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models.
Sallinen J, Holappa J, Koivisto A, Kuokkanen K, Chapman H, Lehtimäki J, Piepponen P, Mijatovic J, Tanila H, Virtanen R, Sirviö J, Haapalinna A. Sallinen J, et al. Among authors: haapalinna a. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):239-49. doi: 10.1111/bcpt.12090. Epub 2013 Jun 20. Basic Clin Pharmacol Toxicol. 2013. PMID: 23718812 Free article.
Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models.
Leino T, Viitamaa T, Haapalinna A, Lehtimäki J, Virtanen R. Leino T, et al. Among authors: haapalinna a. Naunyn Schmiedebergs Arch Pharmacol. 2009 Dec;380(6):539-50. doi: 10.1007/s00210-009-0460-6. Epub 2009 Oct 14. Naunyn Schmiedebergs Arch Pharmacol. 2009. PMID: 19826791
In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action.
Lehtimäki J, Leino T, Koivisto A, Viitamaa T, Lehtimäki T, Haapalinna A, Kuokkanen K, Virtanen R. Lehtimäki J, et al. Among authors: haapalinna a. Eur J Pharmacol. 2008 Dec 3;599(1-3):65-71. doi: 10.1016/j.ejphar.2008.10.003. Epub 2008 Oct 9. Eur J Pharmacol. 2008. PMID: 18930723
The adrenergic alpha2 receptor and sexual incentive motivation in male rats.
Viitamaa T, Haapalinna A, Agmo A. Viitamaa T, et al. Among authors: haapalinna a. Pharmacol Biochem Behav. 2006 Mar;83(3):360-9. doi: 10.1016/j.pbb.2006.02.015. Epub 2006 Mar 6. Pharmacol Biochem Behav. 2006. PMID: 16574206
alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice.
Juhila J, Honkanen A, Sallinen J, Haapalinna A, Korpi ER, Scheinin M. Juhila J, et al. Among authors: haapalinna a. Eur J Pharmacol. 2005 Jul 4;517(1-2):74-83. doi: 10.1016/j.ejphar.2005.05.022. Eur J Pharmacol. 2005. PMID: 15978573
The alpha 2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in rats.
Haapalinna A, Leino T, Heinonen E. Haapalinna A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):342-51. doi: 10.1007/s00210-003-0827-z. Epub 2003 Oct 18. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 14566451
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