The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
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J Biol Chem. 1998 Feb 6;273(6):3205-11. doi: 10.1074/jbc.273.6.3205.
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PMID: 9452432
Free article.
H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. ...This could explain the surprising finding that the Deltaexon 9 mutation is functionally active, although it cannot be proteolytically p …
H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N …