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Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C. Dormann D, et al. Among authors: haass c. J Neurochem. 2009 Aug;110(3):1082-94. doi: 10.1111/j.1471-4159.2009.06211.x. Epub 2009 Jun 9. J Neurochem. 2009. PMID: 19522733 Free article.
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. Capell A, et al. Among authors: haass c. J Biol Chem. 1998 Feb 6;273(6):3205-11. doi: 10.1074/jbc.273.6.3205. J Biol Chem. 1998. PMID: 9452432 Free article.
H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. ...This could explain the surprising finding that the Deltaexon 9 mutation is functionally active, although it cannot be proteolytically p …
H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N …
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, Ihara Y. Oyama F, et al. Among authors: haass c. J Neurochem. 1998 Jul;71(1):313-22. doi: 10.1046/j.1471-4159.1998.71010313.x. J Neurochem. 1998. PMID: 9648880 Free article.
Proteolytic processing of Alzheimer's disease associated proteins.
Haass C, Grünberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R. Haass C, et al. J Neural Transm Suppl. 1998;53:159-67. doi: 10.1007/978-3-7091-6467-9_14. J Neural Transm Suppl. 1998. PMID: 9700654 Review.
460 results