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Page 1
Involvement of the 14-3-3 Gene Family in Autism Spectrum Disorder and Schizophrenia: Genetics, Transcriptomics and Functional Analyses.
Torrico B, Antón-Galindo E, Fernàndez-Castillo N, Rojo-Francàs E, Ghorbani S, Pineda-Cirera L, Hervás A, Rueda I, Moreno E, Fullerton JM, Casadó V, Buitelaar JK, Rommelse N, Franke B, Reif A, Chiocchetti AG, Freitag C, Kleppe R, Haavik J, Toma C, Cormand B. Torrico B, et al. Among authors: haavik j. J Clin Med. 2020 Jun 13;9(6):1851. doi: 10.3390/jcm9061851. J Clin Med. 2020. PMID: 32545830 Free PMC article.
Here, we explored the contribution of the seven human 14-3-3 family members in ASD and other psychiatric disorders by investigating the: (i) functional impact of the 14-3-3zeta mutation p.L220Ffs*18 by assessing solubility, target binding and dimerizat …
Here, we explored the contribution of the seven human 14-3-3 family members in ASD and other psychiatric disorders by investig …
The 14-3-3 proteins in regulation of cellular metabolism.
Kleppe R, Martinez A, Døskeland SO, Haavik J. Kleppe R, et al. Among authors: haavik j. Semin Cell Dev Biol. 2011 Sep;22(7):713-9. doi: 10.1016/j.semcdb.2011.08.008. Epub 2011 Aug 22. Semin Cell Dev Biol. 2011. PMID: 21888985 Free article. Review.
Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that modulate cellular and w …
Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In t …
Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.
Waløen K, Kleppe R, Martinez A, Haavik J. Waløen K, et al. Among authors: haavik j. Expert Opin Ther Targets. 2017 Feb;21(2):167-180. doi: 10.1080/14728222.2017.1272581. Epub 2016 Dec 26. Expert Opin Ther Targets. 2017. PMID: 27973928 Free article. Review.
Interactions with inhibitors, pharmacological chaperones, and regulatory proteins relevant for drug development. Expert opinion: Established inhibitors of these enzymes mainly target their amino acid substrate binding site, while tetrahydrobiopterin analogues, iron chelato …
Interactions with inhibitors, pharmacological chaperones, and regulatory proteins relevant for drug development. Expert opinion: Esta …
Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins.
Waløen K, Jung-Kc K, Vecchia ED, Pandey S, Gasparik N, Døskeland A, Patil S, Kleppe R, Hritz J, Norton WHJ, Martinez A, Haavik J. Waløen K, et al. Among authors: haavik j. Mol Pharmacol. 2021 Aug;100(2):155-169. doi: 10.1124/molpharm.120.000184. Epub 2021 May 24. Mol Pharmacol. 2021. PMID: 34031189 Free article.
The 14-3-3 proteins constitute a family of adaptor proteins with many binding partners and biological functions, and they are considered promising drug targets in cancer and neuropsychiatry. By screening 1280 small-molecule drugs using differential sca …
The 14-3-3 proteins constitute a family of adaptor proteins with many binding partners and biological functions, …
Serine 19 phosphorylation and 14-3-3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40.
Ghorbani S, Szigetvari PD, Haavik J, Kleppe R. Ghorbani S, et al. Among authors: haavik j. J Neurochem. 2020 Jan;152(1):29-47. doi: 10.1111/jnc.14872. Epub 2019 Oct 20. J Neurochem. 2020. PMID: 31529487 Free article.
Phosphorylated Ser19 (pSer19) provides a binding site for 14-3-3 proteins, a family of multi-target binding adaptor proteins. We hypothesized that pSer19 and 14-3-3 binding can regulate access to the Ser31 and Ser40 sites and modulate the …
Phosphorylated Ser19 (pSer19) provides a binding site for 14-3-3 proteins, a family of multi-target binding adaptor …
Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes.
Halskau Ø Jr, Ying M, Baumann A, Kleppe R, Rodriguez-Larrea D, Almås B, Haavik J, Martinez A. Halskau Ø Jr, et al. Among authors: haavik j. J Biol Chem. 2009 Nov 20;284(47):32758-69. doi: 10.1074/jbc.M109.027706. Epub 2009 Sep 28. J Biol Chem. 2009. PMID: 19801645 Free PMC article.
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines, is activated by phosphorylation-dependent binding to 14-3-3 proteins. The N-terminal domain of TH is also involved in interaction with lipid membranes. We investigated the …
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines, is activated by phosphorylation-dependent binding to …
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins.
Ghorbani S, Fossbakk A, Jorge-Finnigan A, Flydal MI, Haavik J, Kleppe R. Ghorbani S, et al. Among authors: haavik j. Amino Acids. 2016 May;48(5):1221-9. doi: 10.1007/s00726-015-2157-0. Epub 2016 Jan 29. Amino Acids. 2016. PMID: 26825549 Free PMC article.
Tyrosine hydroxylase (TH) is regulated by members of the 14-3-3 protein family. However, knowledge about the variation between 14-3-3 proteins in their regulation of TH is still limited. We examined the binding, effects on activation and dephosp …
Tyrosine hydroxylase (TH) is regulated by members of the 14-3-3 protein family. However, knowledge about the variation between …
Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association.
Kleppe R, Toska K, Haavik J. Kleppe R, et al. Among authors: haavik j. J Neurochem. 2001 May;77(4):1097-107. doi: 10.1046/j.1471-4159.2001.00318.x. J Neurochem. 2001. PMID: 11359875
Tyrosine hydroxylase (TH) has been reported to require binding of 14-3-3 proteins for optimal activation by phosphorylation. We examined the effects of phosphorylation at Ser19, Ser31 and Ser40 of bovine TH and human TH isoforms on their binding to the 14 …
Tyrosine hydroxylase (TH) has been reported to require binding of 14-3-3 proteins for optimal activation by phosphoryla …
Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins.
Kleppe R, Ghorbani S, Martinez A, Haavik J. Kleppe R, et al. Among authors: haavik j. FEBS Lett. 2014 Jan 3;588(1):92-8. doi: 10.1016/j.febslet.2013.11.012. Epub 2013 Nov 20. FEBS Lett. 2014. PMID: 24269229
The 14-3-3 proteins are important effectors of Ser/Thr phosphorylation in eukaryotic cells. ...Consequently, these protein targets will respond differently to interventions that affect 14-3-3 binding affinities or phosphorylation kinetics....
The 14-3-3 proteins are important effectors of Ser/Thr phosphorylation in eukaryotic cells. ...Consequently, these prot …
Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3gamma.
Kleppe R, Rosati S, Jorge-Finnigan A, Alvira S, Ghorbani S, Haavik J, Valpuesta JM, Heck AJ, Martinez A. Kleppe R, et al. Among authors: haavik j. Mol Cell Proteomics. 2014 Aug;13(8):2017-30. doi: 10.1074/mcp.M113.035709. Epub 2014 Jun 19. Mol Cell Proteomics. 2014. PMID: 24947669 Free PMC article.
Phosphorylated tyrosine hydroxylase (TH) can form complexes with 14-3-3 proteins, resulting in enzyme activation and stabilization. Although TH was among the first binding partners identified for these ubiquitous regulatory proteins, the binding stoich …
Phosphorylated tyrosine hydroxylase (TH) can form complexes with 14-3-3 proteins, resulting in enzyme activation and st …
14 results