Haaz MC - Search Results

1

The transformation of irinotecan (CPT-11) to its active metabolite SN-38 by human liver microsomes. Differential hydrolysis for the lactone and carboxylate forms.

Haaz MC, Rivory LP, Riché C, Robert J. Haaz MC, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Aug;356(2):257-62. doi: 10.1007/pl00005049. Naunyn Schmiedebergs Arch Pharmacol. 1997. PMID: 9272733

2

Determination of drug interactions occurring with the metabolic pathways of irinotecan.

Charasson V, Haaz MC, Robert J. Charasson V, et al. Among authors: haaz mc. Drug Metab Dispos. 2002 Jun;30(6):731-3. doi: 10.1124/dmd.30.6.731. Drug Metab Dispos. 2002. PMID: 12019202

3

Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes.

Haaz MC, Riché C, Rivory LP, Robert J. Haaz MC, et al. Drug Metab Dispos. 1998 Aug;26(8):769-74. Drug Metab Dispos. 1998. PMID: 9698291

4

Identification of a new metabolite of CPT-11 (irinotecan): pharmacological properties and activation to SN-38.

Dodds HM, Haaz MC, Riou JF, Robert J, Rivory LP. Dodds HM, et al. Among authors: haaz mc. J Pharmacol Exp Ther. 1998 Jul;286(1):578-83. J Pharmacol Exp Ther. 1998. PMID: 9655905

5

Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions.

Haaz MC, Rivory L, Riché C, Vernillet L, Robert J. Haaz MC, et al. Cancer Res. 1998 Feb 1;58(3):468-72. Cancer Res. 1998. PMID: 9458091 Free article.

6

Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients.

Rivory LP, Riou JF, Haaz MC, Sable S, Vuilhorgne M, Commerçon A, Pond SM, Robert J. Rivory LP, et al. Among authors: haaz mc. Cancer Res. 1996 Aug 15;56(16):3689-94. Cancer Res. 1996. PMID: 8706009 Free article.

7

Glucuronidation of SN-38, the active metabolite of irinotecan, by human hepatic microsomes.

Haaz MC, Rivory L, Jantet S, Ratanasavanh D, Robert J. Haaz MC, et al. Pharmacol Toxicol. 1997 Feb;80(2):91-6. doi: 10.1111/j.1600-0773.1997.tb00289.x. Pharmacol Toxicol. 1997. PMID: 9060040

8

Hepatic extraction, metabolism, and biliary excretion of irinotecan in the isolated perfused rat liver.

Farabos C, Haaz MC, Gires P, Robert J. Farabos C, et al. Among authors: haaz mc. J Pharm Sci. 2001 Jun;90(6):722-31. doi: 10.1002/jps.1028. J Pharm Sci. 2001. PMID: 11357175

9

Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials.

Rivory LP, Haaz MC, Canal P, Lokiec F, Armand JP, Robert J. Rivory LP, et al. Among authors: haaz mc. Clin Cancer Res. 1997 Aug;3(8):1261-6. Clin Cancer Res. 1997. PMID: 9815808 Free article. Clinical Trial.

10

Molecular determinants of the cytotoxicity of platinum compounds: the contribution of in silico research.

Vekris A, Meynard D, Haaz MC, Bayssas M, Bonnet J, Robert J. Vekris A, et al. Among authors: haaz mc. Cancer Res. 2004 Jan 1;64(1):356-62. doi: 10.1158/0008-5472.can-03-2258. Cancer Res. 2004. PMID: 14729645 Free article.

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