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Telomere dysfunction and the initiation of genome instability.
Feldser DM, Hackett JA, Greider CW. Feldser DM, et al. Among authors: hackett ja. Nat Rev Cancer. 2003 Aug;3(8):623-7. doi: 10.1038/nrc1142. Nat Rev Cancer. 2003. PMID: 12894250
End resection initiates genomic instability in the absence of telomerase.
Hackett JA, Greider CW. Hackett JA, et al. Mol Cell Biol. 2003 Dec;23(23):8450-61. doi: 10.1128/mcb.23.23.8450-8461.2003. Mol Cell Biol. 2003. PMID: 14612391 Free PMC article.
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis.
Hackett JA, Greider CW. Hackett JA, et al. Oncogene. 2002 Jan 21;21(4):619-26. doi: 10.1038/sj.onc.1205061. Oncogene. 2002. PMID: 11850787 Review.
Telomere dysfunction increases mutation rate and genomic instability.
Hackett JA, Feldser DM, Greider CW. Hackett JA, et al. Cell. 2001 Aug 10;106(3):275-86. doi: 10.1016/s0092-8674(01)00457-3. Cell. 2001. PMID: 11509177
Telomere length, telomere-binding proteins, and DNA damage signaling.
Hemann MT, Hackett J, IJpma A, Greider CW. Hemann MT, et al. Cold Spring Harb Symp Quant Biol. 2000;65:275-9. doi: 10.1101/sqb.2000.65.275. Cold Spring Harb Symp Quant Biol. 2000. PMID: 12760041 Review. No abstract available.
Molecular aspects of somatic hypermutation of immunoglobulin genes.
Storb U, Peters A, Kim N, Shen HM, Bozek G, Michael N, Hackett J Jr, Klotz E, Reynolds JD, Loeb LA, Martin TE. Storb U, et al. Cold Spring Harb Symp Quant Biol. 1999;64:227-34. doi: 10.1101/sqb.1999.64.227. Cold Spring Harb Symp Quant Biol. 1999. PMID: 11232290 Review. No abstract available.
Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
Rogerson B, Hackett J Jr, Peters A, Haasch D, Storb U. Rogerson B, et al. EMBO J. 1991 Dec;10(13):4331-41. EMBO J. 1991. PMID: 1756738 Free PMC article.
The mechanism of somatic hypermutation studied with transgenic and transfected target genes.
Storb U, Peters A, Klotz E, Rogerson B, Hackett J Jr. Storb U, et al. Semin Immunol. 1996 Jun;8(3):131-40. doi: 10.1006/smim.1996.0017. Semin Immunol. 1996. PMID: 8738912 Review.
Cis-acting sequences that affect somatic hypermutation of Ig genes.
Storb U, Peters A, Klotz E, Kim N, Shen HM, Hackett J, Rogerson B, Martin TE. Storb U, et al. Immunol Rev. 1998 Apr;162:153-60. doi: 10.1111/j.1600-065x.1998.tb01438.x. Immunol Rev. 1998. PMID: 9602361 Review.
Immunoglobulin transgenes as targets for somatic hypermutation.
Storb U, Peters A, Klotz E, Kim N, Shen HM, Hackett J, Rogerson B, O'Brien R, Martin TE. Storb U, et al. Int J Dev Biol. 1998;42(7):977-82. Int J Dev Biol. 1998. PMID: 9853828 Review.
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