Hackos DH - Search Results

1

Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences.

Hackos DH, Hanson JE. Hackos DH, et al. Neuropharmacology. 2017 Jan;112(Pt A):34-45. doi: 10.1016/j.neuropharm.2016.07.037. Epub 2016 Jul 30. Neuropharmacology. 2017. PMID: 27484578 Review.

2

Identification of the molecular trigger for allosteric activation in glycogen phosphorylase.

Browner MF, Hackos D, Fletterick R. Browner MF, et al. Nat Struct Biol. 1994 May;1(5):327-33. doi: 10.1038/nsb0594-327. Nat Struct Biol. 1994. PMID: 7664039

3

Histone deacetylase 2 cell autonomously suppresses excitatory and enhances inhibitory synaptic function in CA1 pyramidal neurons.

Hanson JE, Deng L, Hackos DH, Lo SC, Lauffer BE, Steiner P, Zhou Q. Hanson JE, et al. Among authors: hackos dh. J Neurosci. 2013 Apr 3;33(14):5924-9. doi: 10.1523/JNEUROSCI.3162-12.2013. J Neurosci. 2013. PMID: 23554474 Free PMC article.

4

Pannexin-1 is blocked by its C-terminus through a delocalized non-specific interaction surface.

Dourado M, Wong E, Hackos DH. Dourado M, et al. Among authors: hackos dh. PLoS One. 2014 Jun 9;9(6):e99596. doi: 10.1371/journal.pone.0099596. eCollection 2014. PLoS One. 2014. PMID: 24911976 Free PMC article.

5

TRPA1 as a drug target--promise and challenges.

Chen J, Hackos DH. Chen J, et al. Among authors: hackos dh. Naunyn Schmiedebergs Arch Pharmacol. 2015 Apr;388(4):451-63. doi: 10.1007/s00210-015-1088-3. Epub 2015 Feb 3. Naunyn Schmiedebergs Arch Pharmacol. 2015. PMID: 25640188 Free PMC article. Review.

6

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.

Ahuja S, Mukund S, Deng L, Khakh K, Chang E, Ho H, Shriver S, Young C, Lin S, Johnson JP Jr, Wu P, Li J, Coons M, Tam C, Brillantes B, Sampang H, Mortara K, Bowman KK, Clark KR, Estevez A, Xie Z, Verschoof H, Grimwood M, Dehnhardt C, Andrez JC, Focken T, Sutherlin DP, Safina BS, Starovasnik MA, Ortwine DF, Franke Y, Cohen CJ, Hackos DH, Koth CM, Payandeh J. Ahuja S, et al. Among authors: hackos dh. Science. 2015 Dec 18;350(6267):aac5464. doi: 10.1126/science.aac5464. Science. 2015. PMID: 26680203

7

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

Hackos DH, Lupardus PJ, Grand T, Chen Y, Wang TM, Reynen P, Gustafson A, Wallweber HJ, Volgraf M, Sellers BD, Schwarz JB, Paoletti P, Sheng M, Zhou Q, Hanson JE. Hackos DH, et al. Neuron. 2016 Mar 2;89(5):983-99. doi: 10.1016/j.neuron.2016.01.016. Epub 2016 Feb 11. Neuron. 2016. PMID: 26875626

8

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

Volgraf M, Sellers BD, Jiang Y, Wu G, Ly CQ, Villemure E, Pastor RM, Yuen PW, Lu A, Luo X, Liu M, Zhang S, Sun L, Fu Y, Lupardus PJ, Wallweber HJ, Liederer BM, Deshmukh G, Plise E, Tay S, Reynen P, Herrington J, Gustafson A, Liu Y, Dirksen A, Dietz MG, Liu Y, Wang TM, Hanson JE, Hackos D, Scearce-Levie K, Schwarz JB. Volgraf M, et al. J Med Chem. 2016 Mar 24;59(6):2760-79. doi: 10.1021/acs.jmedchem.5b02010. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26919761

9

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.

Villemure E, Volgraf M, Jiang Y, Wu G, Ly CQ, Yuen PW, Lu A, Luo X, Liu M, Zhang S, Lupardus PJ, Wallweber HJ, Liederer BM, Deshmukh G, Plise E, Tay S, Wang TM, Hanson JE, Hackos DH, Scearce-Levie K, Schwarz JB, Sellers BD. Villemure E, et al. Among authors: hackos dh. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89. doi: 10.1021/acsmedchemlett.6b00388. eCollection 2017 Jan 12. ACS Med Chem Lett. 2016. PMID: 28105280 Free PMC article.

10

Computationally Discovered Potentiating Role of Glycans on NMDA Receptors.

Sinitskiy AV, Stanley NH, Hackos DH, Hanson JE, Sellers BD, Pande VS. Sinitskiy AV, et al. Among authors: hackos dh. Sci Rep. 2017 Apr 5;7:44578. doi: 10.1038/srep44578. Sci Rep. 2017. PMID: 28378791 Free PMC article.

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