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13 results
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Targeting AMPK: a new therapeutic opportunity in breast cancer.
Hadad SM, Fleming S, Thompson AM. Hadad SM, et al. Crit Rev Oncol Hematol. 2008 Jul;67(1):1-7. doi: 10.1016/j.critrevonc.2008.01.007. Epub 2008 Mar 14. Crit Rev Oncol Hematol. 2008. PMID: 18343152 Review.
Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle.
Hadad SM, Hardie DG, Appleyard V, Thompson AM. Hadad SM, et al. Clin Transl Oncol. 2014 Aug;16(8):746-52. doi: 10.1007/s12094-013-1144-8. Epub 2013 Dec 12. Clin Transl Oncol. 2014. PMID: 24338509
Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.
Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, Jellema G, Deharo S, Hardie DG, Pusztai L, Moulder-Thompson S, Dewar JA, Thompson AM. Hadad S, et al. Breast Cancer Res Treat. 2011 Aug;128(3):783-94. doi: 10.1007/s10549-011-1612-1. Epub 2011 Jun 8. Breast Cancer Res Treat. 2011. PMID: 21655990 Clinical Trial.
Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in Patients With Estrogen Receptor-Positive Breast Cancer.
Schmid P, Pinder SE, Wheatley D, Macaskill J, Zammit C, Hu J, Price R, Bundred N, Hadad S, Shia A, Sarker SJ, Lim L, Gazinska P, Woodman N, Korbie D, Trau M, Mainwaring P, Gendreau S, Lackner MR, Derynck M, Wilson TR, Butler H, Earl G, Parker P, Purushotham A, Thompson A. Schmid P, et al. J Clin Oncol. 2016 Jun 10;34(17):1987-94. doi: 10.1200/JCO.2015.63.9179. Epub 2016 Mar 14. J Clin Oncol. 2016. PMID: 26976426 Free PMC article. Clinical Trial.
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC. Cha JH, et al. Mol Cell. 2018 Aug 16;71(4):606-620.e7. doi: 10.1016/j.molcel.2018.07.030. Mol Cell. 2018. PMID: 30118680 Free PMC article.
Histological evaluation of AMPK signalling in primary breast cancer.
Hadad SM, Baker L, Quinlan PR, Robertson KE, Bray SE, Thomson G, Kellock D, Jordan LB, Purdie CA, Hardie DG, Fleming S, Thompson AM. Hadad SM, et al. BMC Cancer. 2009 Sep 1;9:307. doi: 10.1186/1471-2407-9-307. BMC Cancer. 2009. PMID: 19723334 Free PMC article.
Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.
Hadad SM, Appleyard V, Thompson AM. Hadad SM, et al. Breast Cancer Res Treat. 2009 Mar;114(2):391. doi: 10.1007/s10549-008-0016-3. Epub 2008 Apr 18. Breast Cancer Res Treat. 2009. PMID: 18421577 No abstract available.
Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial.
Hadad SM, Coates P, Jordan LB, Dowling RJ, Chang MC, Done SJ, Purdie CA, Goodwin PJ, Stambolic V, Moulder-Thompson S, Thompson AM. Hadad SM, et al. Breast Cancer Res Treat. 2015 Feb;150(1):149-55. doi: 10.1007/s10549-015-3307-5. Epub 2015 Feb 15. Breast Cancer Res Treat. 2015. PMID: 25682077 Clinical Trial.
A prospective comparison of ER, PR, Ki67 and gene expression in paired sequential core biopsies of primary, untreated breast cancer.
Hadad SM, Jordan LB, Roy PG, Purdie CA, Iwamoto T, Pusztai L, Moulder-Thompson SL, Thompson AM. Hadad SM, et al. BMC Cancer. 2016 Sep 22;16(1):745. doi: 10.1186/s12885-016-2788-x. BMC Cancer. 2016. PMID: 27658825 Free PMC article.
Effects of prolonged exposure to low dose metformin in thyroid cancer cell lines.
Kheder S, Sisley K, Hadad S, Balasubramanian SP. Kheder S, et al. J Cancer. 2017 Apr 9;8(6):1053-1061. doi: 10.7150/jca.16584. eCollection 2017. J Cancer. 2017. PMID: 28529619 Free PMC article.
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