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In vitro-in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods.
Poulin P, Kenny JR, Hop CE, Haddad S. Poulin P, et al. Among authors: haddad s. J Pharm Sci. 2012 Feb;101(2):838-51. doi: 10.1002/jps.22792. Epub 2011 Oct 18. J Pharm Sci. 2012. PMID: 22009717
Predictions of bisphenol A hepatic clearance in the isolated perfused rat liver (IPRL): impact of albumin binding and of co-administration with naproxen.
Bounakta S, Bteich M, Mantha M, Poulin P, Haddad S. Bounakta S, et al. Among authors: haddad s. Xenobiotica. 2018 Feb;48(2):135-147. doi: 10.1080/00498254.2017.1294276. Epub 2017 Mar 3. Xenobiotica. 2018. PMID: 28277163
Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling Research.
Poulin P, Haddad S. Poulin P, et al. Among authors: haddad s. J Pharm Sci. 2015 Dec;104(12):4448-4458. doi: 10.1002/jps.24676. Epub 2015 Oct 12. J Pharm Sci. 2015. PMID: 26457988
The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research.
Poulin P, Burczynski FJ, Haddad S. Poulin P, et al. Among authors: haddad s. J Pharm Sci. 2016 Feb;105(2):497-508. doi: 10.1002/jps.24571. Epub 2016 Jan 11. J Pharm Sci. 2016. PMID: 26173749 Review.
Modulation of trichloroethylene in vitro metabolism by different drugs in human.
Cheikh Rouhou M, Haddad S. Cheikh Rouhou M, et al. Among authors: haddad s. Toxicol In Vitro. 2014 Aug;28(5):732-41. doi: 10.1016/j.tiv.2014.03.004. Epub 2014 Mar 14. Toxicol In Vitro. 2014. PMID: 24632077
Hepatocyte composition-based model as a mechanistic tool for predicting the cell suspension: aqueous phase partition coefficient of drugs in in vitro metabolic studies.
Poulin P, Haddad S. Poulin P, et al. Among authors: haddad s. J Pharm Sci. 2013 Aug;102(8):2806-18. doi: 10.1002/jps.23602. Epub 2013 May 13. J Pharm Sci. 2013. PMID: 23670739
This study is an extension of a previously published microsome composition-based model by Poulin and Haddad (Poulin and Haddad. 2011. J Pharm Sci 100:4501-4517), which was converted to the hepatocyte composition-based model. ...The second objective was to make a com …
This study is an extension of a previously published microsome composition-based model by Poulin and Haddad (Poulin and Haddad
Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte data.
Poulin P, Haddad S. Poulin P, et al. Among authors: haddad s. J Pharm Sci. 2013 Sep;102(9):3239-51. doi: 10.1002/jps.23502. Epub 2013 Mar 12. J Pharm Sci. 2013. PMID: 23494893
Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs.
Poulin P, Hop CE, Ho Q, Halladay JS, Haddad S, Kenny JR. Poulin P, et al. Among authors: haddad s. J Pharm Sci. 2012 Nov;101(11):4308-26. doi: 10.1002/jps.23288. Epub 2012 Aug 13. J Pharm Sci. 2012. PMID: 22890957
Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes.
Poulin P, Haddad S. Poulin P, et al. Among authors: haddad s. J Pharm Sci. 2011 Oct;100(10):4501-17. doi: 10.1002/jps.22619. Epub 2011 May 13. J Pharm Sci. 2011. PMID: 21574165
Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism.
Poulin P, Bteich M, Haddad S. Poulin P, et al. Among authors: haddad s. J Pharm Sci. 2017 Nov;106(11):3207-3214. doi: 10.1016/j.xphs.2017.07.004. Epub 2017 Aug 18. J Pharm Sci. 2017. PMID: 28823401
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