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The discrepancy in discrepant analysis.
Hadgu A. Hadgu A. Lancet. 1996 Aug 31;348(9027):592-3. doi: 10.1016/S0140-6736(96)05122-7. Lancet. 1996. PMID: 8774575 Review.
Discrepant analysis is a widely used technique that attempts to provide estimates of sensitivity and specificity in the presence of an imperfect gold-standard. ...This technique should not be adopted for evaluating the performance of a diagnostic test....
Discrepant analysis is a widely used technique that attempts to provide estimates of sensitivity and specificity in the presence of a …
Nucleic acid amplification tests for diagnosis of tuberculous meningitis.
Hadgu A, Sternberg M. Hadgu A, et al. Lancet Infect Dis. 2004 Jan;4(1):9-10; discussion 11-2. doi: 10.1016/s1473-3099(03)00852-1. Lancet Infect Dis. 2004. PMID: 14720560 No abstract available.
Evaluation of nucleic acid amplification tests in the absence of a perfect gold-standard test: a review of the statistical and epidemiologic issues.
Hadgu A, Dendukuri N, Hilden J. Hadgu A, et al. Epidemiology. 2005 Sep;16(5):604-12. doi: 10.1097/01.ede.0000173042.07579.17. Epidemiology. 2005. PMID: 16135935
During the past 10 years, medical diagnostic testing for sexually transmitted infections (STIs) has changed markedly as a result of the rapid expansion and marketing of nucleic acid amplification tests (NAATs). ...Finally, we apply some of these statistical modeling techni …
During the past 10 years, medical diagnostic testing for sexually transmitted infections (STIs) has changed markedly as a result of t …
Bias due to composite reference standards in diagnostic accuracy studies.
Schiller I, van Smeden M, Hadgu A, Libman M, Reitsma JB, Dendukuri N. Schiller I, et al. Among authors: hadgu a. Stat Med. 2016 Apr 30;35(9):1454-70. doi: 10.1002/sim.6803. Epub 2015 Nov 10. Stat Med. 2016. PMID: 26555849
Reproducibility and specificity concerns associated with nucleic acid amplification tests for detecting Chlamydia trachomatis.
Hadgu A, Sternberg M. Hadgu A, et al. Eur J Clin Microbiol Infect Dis. 2009 Jan;28(1):9-15. doi: 10.1007/s10096-008-0586-3. Epub 2008 Jul 19. Eur J Clin Microbiol Infect Dis. 2009. PMID: 18642036 Review.
This is because for many infectious diseases including chlamydia, a true gold standard simply does not exist and, as a result, estimation of test performance parameters in the absence of a gold standard is a difficult and challenging task. ...
This is because for many infectious diseases including chlamydia, a true gold standard simply does not exist and, as a result, …
Discrepant analysis: a biased and an unscientific method for estimating test sensitivity and specificity.
Hadgu A. Hadgu A. J Clin Epidemiol. 1999 Dec;52(12):1231-7. doi: 10.1016/s0895-4356(99)00101-8. J Clin Epidemiol. 1999. PMID: 10580787
Using a typical example from the published literature, I show that the discrepant analysis-based estimates of sensitivity and specificity can generate a significant and clinically important overestimation of the true sensitivity and specificity values. ...It violate …
Using a typical example from the published literature, I show that the discrepant analysis-based estimates of sensitivity and specifi …
Head-to-head evaluation of five chlamydia tests relative to a quality-assured culture standard.
Newhall WJ, Johnson RE, DeLisle S, Fine D, Hadgu A, Matsuda B, Osmond D, Campbell J, Stamm WE. Newhall WJ, et al. J Clin Microbiol. 1999 Mar;37(3):681-5. doi: 10.1128/JCM.37.3.681-685.1999. J Clin Microbiol. 1999. PMID: 9986831 Free PMC article.
All positive results obtained with a nonculture test (except MicroTrak DFA) were confirmed by testing the original specimens with a blocking antibody test (Chlamydiazyme), a cytospin DFA (MicroTrak EIA and Pathfinder EIA), and a probe competition assay …
All positive results obtained with a nonculture test (except MicroTrak DFA) were confirmed by testing the original specimens with …
Screening women for gonorrhea: demographic screening criteria for general clinical use.
Mertz KJ, Levine WC, Mosure DJ, Berman SM, Dorian KJ, Hadgu A. Mertz KJ, et al. Am J Public Health. 1997 Sep;87(9):1535-8. doi: 10.2105/ajph.87.9.1535. Am J Public Health. 1997. PMID: 9314811 Free PMC article.
Sensitivity and specificity for correlated observations.
Smith PJ, Hadgu A. Smith PJ, et al. Stat Med. 1992 Aug;11(11):1503-9. doi: 10.1002/sim.4780111108. Stat Med. 1992. PMID: 1410962
A general estimating equation approach is used to obtain estimates of sensitivity and specificity when the data consist of correlated binary outcomes. ...Data from a dental study are used to motivate and illustrate the methods....
A general estimating equation approach is used to obtain estimates of sensitivity and specificity when the data consist of correlated
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