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Page 1
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors.
Metrano AJ, Morrill LA, Bommakanti G, Casella R, Cook S, Escobar RA, Giblin KA, Gosselin E, Grebe T, Hariparsad N, Howells R, Lamont GM, Mele DA, Pflug A, Proia TA, Rezaei H, Richter M, Richards R, San Martin M, Schimpl M, Schuller AG, Sha L, Sheppeck JE 2nd, Song K, Tang H, Wagner DJ, Wang J, Wu A, Wu D, Wu Y, Xu K, Ye M, Shields JD, Grimster NP. Metrano AJ, et al. Among authors: rezaei h. RSC Med Chem. 2025 May 27. doi: 10.1039/d5md00309a. Online ahead of print. RSC Med Chem. 2025. PMID: 40521343 Free PMC article.
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.
Shields JD, Baker D, Balazs AYS, Bommakanti G, Casella R, Cao S, Cook S, Escobar RA, Fawell S, Gibbons FD, Giblin KA, Goldberg FW, Gosselin E, Grebe T, Hariparsad N, Hatoum-Mokdad H, Howells R, Hughes SJ, Jackson A, Karapa Reddy I, Kettle JG, Lamont GM, Lamont S, Li M, Lill SON, Mele DA, Metrano AJ, Mfuh AM, Morrill LA, Peng B, Pflug A, Proia TA, Rezaei H, Richards R, Richter M, Robbins KJ, San Martin M, Schimpl M, Schuller AG, Sha L, Shen M, Sheppeck JE 2nd, Singh M, Stokes S, Song K, Sun Y, Tang H, Wagner DJ, Wang J, Wang Y, Wilson DM, Wu A, Wu C, Wu D, Wu Y, Xu K, Yang Y, Yao T, Ye M, Zhang AX, Zhang H, Zhai X, Zhou Y, Ziegler RE, Grimster NP. Shields JD, et al. Among authors: rezaei h. J Med Chem. 2025 Feb 27;68(4):4582-4595. doi: 10.1021/acs.jmedchem.4c02631. Epub 2025 Feb 10. J Med Chem. 2025. PMID: 39928839
AiZynth impact on medicinal chemistry practice at AstraZeneca.
Shields JD, Howells R, Lamont G, Leilei Y, Madin A, Reimann CE, Rezaei H, Reuillon T, Smith B, Thomson C, Zheng Y, Ziegler RE. Shields JD, et al. Among authors: rezaei h. RSC Med Chem. 2024 Feb 16;15(4):1085-1095. doi: 10.1039/d3md00651d. eCollection 2024 Apr 24. RSC Med Chem. 2024. PMID: 38665822 Free PMC article.
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