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The pharmacology of the antioxidant lipoic acid.
Biewenga GP, Haenen GR, Bast A. Biewenga GP, et al. Gen Pharmacol. 1997 Sep;29(3):315-31. doi: 10.1016/s0306-3623(96)00474-0. Gen Pharmacol. 1997. PMID: 9378235 Review.
Analysis of oxidative DNA damage after human dietary supplementation with linoleic acid.
de Kok TM, Zwingman I, Moonen EJ, Schilderman PA, Rhijnsburger E, Haenen GR, Kleinjans JC. de Kok TM, et al. Food Chem Toxicol. 2003 Mar;41(3):351-8. doi: 10.1016/s0278-6915(02)00237-5. Food Chem Toxicol. 2003. PMID: 12504167 Clinical Trial.
The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial.
Baumgartner S, Mensink RP, Haenen GR, Bast A, Binder CJ, Bekers O, Husche C, Lütjohann D, Plat J. Baumgartner S, et al. Among authors: haenen gr. Sci Rep. 2017 Nov 10;7(1):15288. doi: 10.1038/s41598-017-15615-y. Sci Rep. 2017. PMID: 29127425 Free PMC article. Clinical Trial.
Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress.
Sthijns MMJPE, Schiffers PM, Janssen GM, Lemmens KJA, Ides B, Vangrieken P, Bouwman FG, Mariman EC, Pader I, Arnér ESJ, Johansson K, Bast A, Haenen GRMM. Sthijns MMJPE, et al. Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1177-1189. doi: 10.1016/j.bbagen.2017.03.004. Epub 2017 Mar 7. Biochim Biophys Acta Gen Subj. 2017. PMID: 28286015
Bioavailability and pharmacokinetics of the cardioprotecting flavonoid 7-monohydroxyethylrutoside in mice.
Abou El Hassan MA, Kedde MA, Zwiers UT, Tourn E, Haenen GR, Bast A, van der Vijgh WJ. Abou El Hassan MA, et al. Cancer Chemother Pharmacol. 2003 Nov;52(5):371-6. doi: 10.1007/s00280-003-0667-z. Epub 2003 Jul 31. Cancer Chemother Pharmacol. 2003. PMID: 12898182
Partial bladder outlet obstruction reduces the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder.
de Jongh R, Dambros M, Haenen GR, den Hartog GJ, Bast A, van Kerrebroeck PE, van Koeveringe GA. de Jongh R, et al. Neurourol Urodyn. 2009;28(5):461-7. doi: 10.1002/nau.20677. Neurourol Urodyn. 2009. PMID: 19090590
The total antioxidant capacity, the glutathione and the glutathione reductase (GR) levels significantly decreased in obstructed bladders compared to the sham group. ...
The total antioxidant capacity, the glutathione and the glutathione reductase (GR) levels significantly decreased in obstructed bladd …
The flavanol (-)-epicatechin and its metabolites protect against oxidative stress in primary endothelial cells via a direct antioxidant effect.
Ruijters EJ, Weseler AR, Kicken C, Haenen GR, Bast A. Ruijters EJ, et al. Eur J Pharmacol. 2013 Sep 5;715(1-3):147-53. doi: 10.1016/j.ejphar.2013.05.029. Epub 2013 Jun 4. Eur J Pharmacol. 2013. PMID: 23747595
Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage.
Vanhees K, van Schooten FJ, van Waalwijk van Doorn-Khosrovani SB, van Helden S, Munnia A, Peluso M, Briedé JJ, Haenen GR, Godschalk RW. Vanhees K, et al. Free Radic Biol Med. 2013 Apr;57:154-61. doi: 10.1016/j.freeradbiomed.2012.12.021. Epub 2013 Jan 4. Free Radic Biol Med. 2013. PMID: 23295412
Structure and activity in assessing antioxidant activity in vitro and in vivo A critical appraisal illustrated with the flavonoids.
Haenen GR, Arts MJ, Bast A, Coleman MD. Haenen GR, et al. Environ Toxicol Pharmacol. 2006 Feb;21(2):191-8. doi: 10.1016/j.etap.2005.07.010. Epub 2005 Aug 15. Environ Toxicol Pharmacol. 2006. PMID: 21783657
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