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The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.
Sents W, Ivanova E, Lambrecht C, Haesen D, Janssens V. Sents W, et al. Among authors: haesen d. FEBS J. 2013 Jan;280(2):644-61. doi: 10.1111/j.1742-4658.2012.08579.x. Epub 2012 Apr 25. FEBS J. 2013. PMID: 22443683 Free article. Review.
De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.
Reynhout S, Jansen S, Haesen D, van Belle S, de Munnik SA, Bongers EMHF, Schieving JH, Marcelis C, Amiel J, Rio M, Mclaughlin H, Ladda R, Sell S, Kriek M, Peeters-Scholte CMPCD, Terhal PA, van Gassen KL, Verbeek N, Henry S, Scott Schwoerer J, Malik S, Revencu N, Ferreira CR, Macnamara E, Braakman HMH, Brimble E, Ruzhnikov MRZ, Wagner M, Harrer P, Wieczorek D, Kuechler A, Tziperman B, Barel O, de Vries BBA, Gordon CT, Janssens V, Vissers LELM. Reynhout S, et al. Among authors: haesen d. Am J Hum Genet. 2019 Jan 3;104(1):139-156. doi: 10.1016/j.ajhg.2018.12.002. Epub 2018 Dec 27. Am J Hum Genet. 2019. PMID: 30595372 Free PMC article.
PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.
Sents W, Meeusen B, Kalev P, Radaelli E, Sagaert X, Miermans E, Haesen D, Lambrecht C, Dewerchin M, Carmeliet P, Westermarck J, Sablina A, Janssens V. Sents W, et al. Among authors: haesen d. Cancer Res. 2017 Dec 15;77(24):6825-6837. doi: 10.1158/0008-5472.CAN-16-2911. Epub 2017 Oct 18. Cancer Res. 2017. PMID: 29046336 Free article.
Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.
Haesen D, Abbasi Asbagh L, Derua R, Hubert A, Schrauwen S, Hoorne Y, Amant F, Waelkens E, Sablina A, Janssens V. Haesen D, et al. Cancer Res. 2016 Oct 1;76(19):5719-5731. doi: 10.1158/0008-5472.CAN-15-3342. Epub 2016 Aug 2. Cancer Res. 2016. PMID: 27485451 Free article.
The Basic Biology of PP2A in Hematologic Cells and Malignancies.
Haesen D, Sents W, Lemaire K, Hoorne Y, Janssens V. Haesen D, et al. Front Oncol. 2014 Dec 11;4:347. doi: 10.3389/fonc.2014.00347. eCollection 2014. Front Oncol. 2014. PMID: 25566494 Free PMC article. Review.
Structure, regulation, and pharmacological modulation of PP2A phosphatases.
Lambrecht C, Haesen D, Sents W, Ivanova E, Janssens V. Lambrecht C, et al. Among authors: haesen d. Methods Mol Biol. 2013;1053:283-305. doi: 10.1007/978-1-62703-562-0_17. Methods Mol Biol. 2013. PMID: 23860660 Review.
De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.
Reynhout S, Jansen S, Haesen D, van Belle S, de Munnik SA, Bongers EMHF, Schieving JH, Marcelis C, Amiel J, Rio M, Mclaughlin H, Ladda R, Sell S, Kriek M, Peeters-Scholte CMPCD, Terhal PA, van Gassen KL, Verbeek N, Henry S, Schwoerer JS, Malik S, Revencu N, Ferreira CR, Macnamara E, Braakman HMH, Brimble E, Ruzhnikov MRZ, Wagner M, Harrer P, Wieczorek D, Kuechler A, Tziperman B, Barel O, de Vries BBA, Gordon CT, Janssens V, Vissers LELM. Reynhout S, et al. Among authors: haesen d. Am J Hum Genet. 2019 Feb 7;104(2):357. doi: 10.1016/j.ajhg.2019.01.003. Am J Hum Genet. 2019. PMID: 30735662 Free PMC article. No abstract available.
Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras.
Peeters K, Van Leemputte F, Fischer B, Bonini BM, Quezada H, Tsytlonok M, Haesen D, Vanthienen W, Bernardes N, Gonzalez-Blas CB, Janssens V, Tompa P, Versées W, Thevelein JM. Peeters K, et al. Among authors: haesen d. Nat Commun. 2017 Oct 13;8(1):922. doi: 10.1038/s41467-017-01019-z. Nat Commun. 2017. PMID: 29030545 Free PMC article.
B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.
Houge G, Haesen D, Vissers LE, Mehta S, Parker MJ, Wright M, Vogt J, McKee S, Tolmie JL, Cordeiro N, Kleefstra T, Willemsen MH, Reijnders MR, Berland S, Hayman E, Lahat E, Brilstra EH, van Gassen KL, Zonneveld-Huijssoon E, de Bie CI, Hoischen A, Eichler EE, Holdhus R, Steen VM, Døskeland SO, Hurles ME, FitzPatrick DR, Janssens V. Houge G, et al. Among authors: haesen d. J Clin Invest. 2015 Aug 3;125(8):3051-62. doi: 10.1172/JCI79860. Epub 2015 Jul 13. J Clin Invest. 2015. PMID: 26168268 Free PMC article.
Endovascular treatment of atherosclerotic lesions in the superficial femoral artery and proximal popliteal artery using the sinus-SuperFlex-635 stent: twelve-month results from the HERO Registry.
Hendriks JM, Dubois M, Lauwers P, de Vleeschauwer P, Vanbetsbrugge M, Deleersnijder R, Wustenberghs K, Robijn J, Jacobs B, Willaert W, Vandekerkhof J, Keirse K, Gabriëls K, Hoppenbrouwers M, Haesen D. Hendriks JM, et al. Among authors: haesen d. J Cardiovasc Surg (Torino). 2020 Feb;61(1):84-92. doi: 10.23736/S0021-9509.19.11028-2. J Cardiovasc Surg (Torino). 2020. PMID: 32079379
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