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Imaging the default mode network in aging and dementia.
Hafkemeijer A, van der Grond J, Rombouts SA. Hafkemeijer A, et al. Biochim Biophys Acta. 2012 Mar;1822(3):431-41. doi: 10.1016/j.bbadis.2011.07.008. Epub 2011 Jul 23. Biochim Biophys Acta. 2012. PMID: 21807094 Review.
The majority of studies show a decreased DMN functional connectivity and task-induced DMN deactivations along a continuum from normal aging to mild cognitive impairment and to Alzheimer's disease (AD). ...While fMRI is a useful tool for detecting changes in D …
The majority of studies show a decreased DMN functional connectivity and task-induced DMN deactivations along a continuum from …
Cholesterol and synaptic compensatory mechanisms in Alzheimer's disease mice brain during aging.
Jansen D, Janssen CI, Vanmierlo T, Dederen PJ, van Rooij D, Zinnhardt B, Nobelen CL, Janssen AL, Hafkemeijer A, Mutsaers MP, Doedée AM, Kuipers AA, Broersen LM, Mulder M, Kiliaan AJ. Jansen D, et al. J Alzheimers Dis. 2012;31(4):813-26. doi: 10.3233/JAD-2012-120298. J Alzheimers Dis. 2012. PMID: 22717611
These findings suggest a synaptic compensatory response to maintain connectivity during aging. We hypothesize that high cholesterol intake may cause impaired cerebral blood flow inducing ischemia, fortifying the above mentioned hypothesis of a compensatory mechanism …
These findings suggest a synaptic compensatory response to maintain connectivity during aging. We hypothesize that high cholesterol i …
Increased functional connectivity and brain atrophy in elderly with subjective memory complaints.
Hafkemeijer A, Altmann-Schneider I, Oleksik AM, van de Wiel L, Middelkoop HA, van Buchem MA, van der Grond J, Rombouts SA. Hafkemeijer A, et al. Brain Connect. 2013;3(4):353-62. doi: 10.1089/brain.2013.0144. Epub 2013 Jun 21. Brain Connect. 2013. PMID: 23627661 Free PMC article.
This suggests that self-reported SMC is a reflection of objective alterations in brain function. Furthermore, our results indicate that functional imaging, in addition to structural imaging, can be a useful tool to objectively determine a difference in brain …
This suggests that self-reported SMC is a reflection of objective alterations in brain function. Furthermore, our results indicate th …
A longitudinal study of cognition, proton MR spectroscopy and synaptic and neuronal pathology in aging wild-type and AβPPswe-PS1dE9 mice.
Jansen D, Zerbi V, Janssen CI, Dederen PJ, Mutsaers MP, Hafkemeijer A, Janssen AL, Nobelen CL, Veltien A, Asten JJ, Heerschap A, Kiliaan AJ. Jansen D, et al. PLoS One. 2013 May 22;8(5):e63643. doi: 10.1371/journal.pone.0063643. Print 2013. PLoS One. 2013. PMID: 23717459 Free PMC article.
Proton magnetic resonance spectroscopy ((1)H MRS) is a valuable tool in Alzheimer's disease research, investigating the functional integrity of the brain. ...Furthermore, correlation analyses suggest a possible role of Aβ in inflammatory processes, synaptic dysfunct …
Proton magnetic resonance spectroscopy ((1)H MRS) is a valuable tool in Alzheimer's disease research, investigating the functional in …
Associations between age and gray matter volume in anatomical brain networks in middle-aged to older adults.
Hafkemeijer A, Altmann-Schneider I, de Craen AJ, Slagboom PE, van der Grond J, Rombouts SA. Hafkemeijer A, et al. Aging Cell. 2014 Dec;13(6):1068-74. doi: 10.1111/acel.12271. Epub 2014 Sep 25. Aging Cell. 2014. PMID: 25257192 Free PMC article.
For each of 370 subjects, we acquired a T1-weighted anatomical MRI scan. After segmentation of structural MRI scans, nine anatomical networks were defined based on structural covariance of gray matter volume among subjects. ...Age was negatively associated with gray matter …
For each of 370 subjects, we acquired a T1-weighted anatomical MRI scan. After segmentation of structural MRI scans, nine anatomical …
Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease.
Hafkemeijer A, Möller C, Dopper EG, Jiskoot LC, Schouten TM, van Swieten JC, van der Flier WM, Vrenken H, Pijnenburg YA, Barkhof F, Scheltens P, van der Grond J, Rombouts SA. Hafkemeijer A, et al. Front Hum Neurosci. 2015 Sep 8;9:474. doi: 10.3389/fnhum.2015.00474. eCollection 2015. Front Hum Neurosci. 2015. PMID: 26441584 Free PMC article.
A general linear model approach was used to study group differences, while controlling for physiological noise, age, gender, study center, and regional gray matter volume. RESULTS: Given gray matter differences, we observed decreased network-to-region connectivity in bvFTD
A general linear model approach was used to study group differences, while controlling for physiological noise, age, gender, study ce
Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD: A two-center study.
Möller C, Hafkemeijer A, Pijnenburg YA, Rombouts SA, van der Grond J, Dopper E, van Swieten J, Versteeg A, Pouwels PJ, Barkhof F, Scheltens P, Vrenken H, van der Flier WM. Möller C, et al. Neuroimage Clin. 2015 Sep 9;9:418-29. doi: 10.1016/j.nicl.2015.08.022. eCollection 2015. Neuroimage Clin. 2015. PMID: 26594624 Free PMC article. Clinical Trial.
Alzheimer Disease and Behavioral Variant Frontotemporal Dementia: Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis.
Möller C, Pijnenburg YA, van der Flier WM, Versteeg A, Tijms B, de Munck JC, Hafkemeijer A, Rombouts SA, van der Grond J, van Swieten J, Dopper E, Scheltens P, Barkhof F, Vrenken H, Wink AM. Möller C, et al. Radiology. 2016 Jun;279(3):838-48. doi: 10.1148/radiol.2015150220. Epub 2015 Dec 11. Radiology. 2016. PMID: 26653846
Training of a support vector machine (SVM) classifier used diagnostic status and GM density maps and produced voxelwise discrimination maps. ...Conclusion The SVM can be used in single-subject discrimination and can help the clinician arrive at a diagnosis. The SVM …
Training of a support vector machine (SVM) classifier used diagnostic status and GM density maps and produced voxelwise discriminatio …
Differences in structural covariance brain networks between behavioral variant frontotemporal dementia and Alzheimer's disease.
Hafkemeijer A, Möller C, Dopper EG, Jiskoot LC, van den Berg-Huysmans AA, van Swieten JC, van der Flier WM, Vrenken H, Pijnenburg YA, Barkhof F, Scheltens P, van der Grond J, Rombouts SA. Hafkemeijer A, et al. Hum Brain Mapp. 2016 Mar;37(3):978-88. doi: 10.1002/hbm.23081. Epub 2015 Dec 10. Hum Brain Mapp. 2016. PMID: 26660857 Free PMC article. Clinical Trial.
Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease.
Möller C, Hafkemeijer A, Pijnenburg YAL, Rombouts SARB, van der Grond J, Dopper E, van Swieten J, Versteeg A, Steenwijk MD, Barkhof F, Scheltens P, Vrenken H, van der Flier WM. Möller C, et al. Neurobiol Aging. 2016 Feb;38:21-31. doi: 10.1016/j.neurobiolaging.2015.10.020. Epub 2015 Oct 30. Neurobiol Aging. 2016. PMID: 26827640
Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had …
Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease o …
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