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Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?
Caldwell GW, Masucci JA, Yan Z, Hageman W. Caldwell GW, et al. Among authors: hageman w. Eur J Drug Metab Pharmacokinet. 2004 Apr-Jun;29(2):133-43. doi: 10.1007/BF03190588. Eur J Drug Metab Pharmacokinet. 2004. PMID: 15230342
The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens.
Caldwell GW, Ritchie DM, Masucci JA, Hageman W, Cotto C, Hall J, Hasting B, Jones W. Caldwell GW, et al. Among authors: hageman w. Eur J Drug Metab Pharmacokinet. 2005 Jan-Jun;30(1-2):75-83. doi: 10.1007/BF03226411. Eur J Drug Metab Pharmacokinet. 2005. PMID: 16010865
Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery.
Lang W, Masucci JA, Caldwell GW, Hageman W, Hall J, Jones WJ, Rafferty BM. Lang W, et al. Among authors: hageman w. Anal Biochem. 2004 Oct 1;333(1):79-87. doi: 10.1016/j.ab.2004.07.001. Anal Biochem. 2004. PMID: 15351283
Improved pharmacokinetic and bioavailability support of drug discovery using serial blood sampling in mice.
Peng SX, Rockafellow BA, Skedzielewski TM, Huebert ND, Hageman W. Peng SX, et al. Among authors: hageman w. J Pharm Sci. 2009 May;98(5):1877-84. doi: 10.1002/jps.21533. J Pharm Sci. 2009. PMID: 18803263
The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery.
Caldwell GW, Ritchie DM, Masucci JA, Hageman W, Yan Z. Caldwell GW, et al. Among authors: hageman w. Curr Top Med Chem. 2001 Nov;1(5):353-66. doi: 10.2174/1568026013394949. Curr Top Med Chem. 2001. PMID: 11899102 Review.
Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin.
Matthews JM, Liotta F, Hageman W, Rivero RA, Westover L, Yang M, Xu J, Demarest K. Matthews JM, et al. Among authors: hageman w. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1155-9. doi: 10.1016/j.bmcl.2003.12.071. Bioorg Med Chem Lett. 2004. PMID: 14980655
Characterization of RWJ-351647, a novel nonpeptide vasopressin V2 receptor antagonist.
Gunnet JW, Matthews JM, Maryanoff BE, de Garavilla L, Andrade-Gordon P, Damiano B, Hageman W, Look R, Stahle P, Streeter AJ, Wines PG, Demarest KT. Gunnet JW, et al. Among authors: hageman w. Clin Exp Pharmacol Physiol. 2006 Apr;33(4):320-6. doi: 10.1111/j.1440-1681.2006.04369.x. Clin Exp Pharmacol Physiol. 2006. PMID: 16620295
Discovery of the first non-peptide antagonist of the motilin receptor.
Beavers MP, Gunnet JW, Hageman W, Miller W, Moore JB, Zhou L, Chen RH, Xiang A, Urbanski M, Combs DW, Mayo KH, Demarest KT. Beavers MP, et al. Among authors: hageman w. Drug Des Discov. 2001;17(3):243-51. Drug Des Discov. 2001. PMID: 11469754
Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity.
Dyatkin AB, Hoekstra WJ, Hlasta DJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Gunnet JW, Hageman W, Look R, Maryanoff BE. Dyatkin AB, et al. Among authors: hageman w. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3081-4. doi: 10.1016/s0960-894x(02)00649-2. Bioorg Med Chem Lett. 2002. PMID: 12372506
1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability.
Ghosh S, Santulli RJ, Kinney WA, Decorte BL, Liu L, Lewis JM, Proost JC, Leo GC, Masucci J, Hageman WE, Thompson AS, Chen I, Kawahama R, Tuman RW, Galemmo RA Jr, Johnson DL, Damiano BP, Maryanoff BE. Ghosh S, et al. Among authors: hageman we. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41. doi: 10.1016/j.bmcl.2004.08.067. Bioorg Med Chem Lett. 2004. PMID: 15501072
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