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Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.
Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P. Pozo N, et al. Among authors: hagiwara m. J Clin Invest. 2013 Jun;123(6):2475-87. doi: 10.1172/JCI63623. Epub 2013 May 1. J Clin Invest. 2013. PMID: 23635774 Free PMC article.
DYRK1A and cognition: A lifelong relationship.
Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM. Arbones ML, et al. Among authors: hagiwara m. Pharmacol Ther. 2019 Feb;194:199-221. doi: 10.1016/j.pharmthera.2018.09.010. Epub 2018 Sep 28. Pharmacol Ther. 2019. PMID: 30268771 Review.
CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses.
Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T, Ito N, Hosoya T, Hagiwara M. Yamamoto M, et al. Among authors: hagiwara m. J Clin Invest. 2014 Aug;124(8):3479-88. doi: 10.1172/JCI73805. Epub 2014 Jul 8. J Clin Invest. 2014. PMID: 25003190 Free PMC article.
Selective inhibition of the kinase DYRK1A by targeting its folding process.
Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, Hagiwara M. Kii I, et al. Among authors: hagiwara m. Nat Commun. 2016 Apr 22;7:11391. doi: 10.1038/ncomms11391. Nat Commun. 2016. PMID: 27102360 Free PMC article.
940 results