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The functional impact of SLC6 transporter genetic variation.
Hahn MK, Blakely RD. Hahn MK, et al. Annu Rev Pharmacol Toxicol. 2007;47:401-41. doi: 10.1146/annurev.pharmtox.47.120505.105242. Annu Rev Pharmacol Toxicol. 2007. PMID: 17067279 Review.
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.
Kim CH, Hahn MK, Joung Y, Anderson SL, Steele AH, Mazei-Robinson MS, Gizer I, Teicher MH, Cohen BM, Robertson D, Waldman ID, Blakely RD, Kim KS. Kim CH, et al. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19164-9. doi: 10.1073/pnas.0510836103. Epub 2006 Dec 4. Proc Natl Acad Sci U S A. 2006. PMID: 17146058 Free PMC article.
Novel and functional norepinephrine transporter protein variants identified in attention-deficit hyperactivity disorder.
Hahn MK, Steele A, Couch RS, Stein MA, Krueger JJ. Hahn MK, et al. Neuropharmacology. 2009 Dec;57(7-8):694-701. doi: 10.1016/j.neuropharm.2009.08.002. Epub 2009 Aug 19. Neuropharmacology. 2009. PMID: 19698724 Free PMC article. Clinical Trial.
Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.
Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D. Kohli U, et al. Physiol Genomics. 2015 Sep;47(9):400-6. doi: 10.1152/physiolgenomics.00124.2014. Epub 2015 Jun 9. Physiol Genomics. 2015. PMID: 26058836 Free PMC article.
Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis.
Ma Y, Krueger JJ, Redmon SN, Uppuganti S, Nyman JS, Hahn MK, Elefteriou F. Ma Y, et al. J Biol Chem. 2013 Oct 18;288(42):30105-13. doi: 10.1074/jbc.M113.481309. Epub 2013 Sep 4. J Biol Chem. 2013. PMID: 24005671 Free PMC article.
Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice.
Davis GL, Stewart A, Stanwood GD, Gowrishankar R, Hahn MK, Blakely RD. Davis GL, et al. Behav Brain Res. 2018 Jan 30;337:61-69. doi: 10.1016/j.bbr.2017.09.043. Epub 2017 Sep 28. Behav Brain Res. 2018. PMID: 28964912 Free PMC article.
The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.
Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD. Mergy MA, et al. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4779-88. doi: 10.1073/pnas.1417294111. Epub 2014 Oct 20. Proc Natl Acad Sci U S A. 2014. PMID: 25331903 Free PMC article.
Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder.
Mergy MA, Gowrishankar R, Davis GL, Jessen TN, Wright J, Stanwood GD, Hahn MK, Blakely RD. Mergy MA, et al. Neurochem Int. 2014 Jul;73:56-70. doi: 10.1016/j.neuint.2013.11.009. Epub 2013 Dec 8. Neurochem Int. 2014. PMID: 24332984 Free PMC article. Review.
Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome.
Shirey-Rice JK, Klar R, Fentress HM, Redmon SN, Sabb TR, Krueger JJ, Wallace NM, Appalsamy M, Finney C, Lonce S, Diedrich A, Hahn MK. Shirey-Rice JK, et al. Dis Model Mech. 2013 Jul;6(4):1001-11. doi: 10.1242/dmm.012203. Epub 2013 Apr 4. Dis Model Mech. 2013. PMID: 23580201 Free PMC article.
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