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Dim light at night provokes depression-like behaviors and reduces CA1 dendritic spine density in female hamsters.
Bedrosian TA, Fonken LK, Walton JC, Haim A, Nelson RJ. Bedrosian TA, et al. Psychoneuroendocrinology. 2011 Aug;36(7):1062-9. doi: 10.1016/j.psyneuen.2011.01.004. Epub 2011 Feb 2. Psychoneuroendocrinology. 2011. PMID: 21292405
Ovariectomized adult female Siberian hamsters (Phodopus sungorus) were housed for 8 weeks in either a light/dark cycle (LD) or a light/dim light cycle (DM), and then behavior was assayed. ...
Ovariectomized adult female Siberian hamsters (Phodopus sungorus) were housed for 8 weeks in either a light/dark cycle (LD) or a
Light at night increases body mass by shifting the time of food intake.
Fonken LK, Workman JL, Walton JC, Weil ZM, Morris JS, Haim A, Nelson RJ. Fonken LK, et al. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18664-9. doi: 10.1073/pnas.1008734107. Epub 2010 Oct 11. Proc Natl Acad Sci U S A. 2010. PMID: 20937863 Free PMC article.
To determine whether a causal relationship exists between nighttime light exposure and obesity, we examined the effects of LAN on body mass in male mice. Mice housed in either bright (LL) or dim (DM) LAN have significantly increased body mass and reduced glucose tolerance …
To determine whether a causal relationship exists between nighttime light exposure and obesity, we examined the effects of LAN on bod …
Does artificial light-at-night exposure contribute to the worldwide obesity pandemic?
Rybnikova NA, Haim A, Portnov BA. Rybnikova NA, et al. Int J Obes (Lond). 2016 May;40(5):815-23. doi: 10.1038/ijo.2015.255. Epub 2016 Jan 22. Int J Obes (Lond). 2016. PMID: 26795746
Increasing exposure to artificial light-at-night (ALAN) may influence body mass, by suppression of melatonin production and disruption of daily rhythms, resulting in physiological or behavioral changes in the human body, and may thus become a driving force behind worldwide …
Increasing exposure to artificial light-at-night (ALAN) may influence body mass, by suppression of melatonin production and disruption of da …
Altered metabolic and hormonal responses in male rats exposed to acute bright light-at-night associated with global DNA hypo-methylation.
Yonis M, Haim A, Zubidat AE. Yonis M, et al. J Photochem Photobiol B. 2019 May;194:107-118. doi: 10.1016/j.jphotobiol.2019.03.020. Epub 2019 Mar 28. J Photochem Photobiol B. 2019. PMID: 30953912
The flexibility of epigenetic modifications provides a potential therapeutic target for rectifying ALAN adverse effects by epigenetic markers such as melatonin and behavioral lifestyle interventions for confining ALAN exposures as much as possible....
The flexibility of epigenetic modifications provides a potential therapeutic target for rectifying ALAN adverse effects by epigenetic …
Artificial light at night: melatonin as a mediator between the environment and epigenome.
Haim A, Zubidat AE. Haim A, et al. Philos Trans R Soc Lond B Biol Sci. 2015 May 5;370(1667):20140121. doi: 10.1098/rstb.2014.0121. Philos Trans R Soc Lond B Biol Sci. 2015. PMID: 25780234 Free PMC article. Review.
Here we propose a possible genetic link between environmental exposure and tumorigenesis processes. We discuss evidence related to the relationship between epigenetic remodelling and oncogene expression. ...A putative mechanism of action involving epigenetic modific …
Here we propose a possible genetic link between environmental exposure and tumorigenesis processes. We discuss evidence related to th …
Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways.
Zubidat AE, Fares B, Fares F, Haim A. Zubidat AE, et al. Cancer Control. 2018 Jan-Dec;25(1):1073274818812908. doi: 10.1177/1073274818812908. Cancer Control. 2018. PMID: 30477310 Free PMC article.
Evening light exposure to computer screens disrupts human sleep, biological rhythms, and attention abilities.
Green A, Cohen-Zion M, Haim A, Dagan Y. Green A, et al. Chronobiol Int. 2017;34(7):855-865. doi: 10.1080/07420528.2017.1324878. Epub 2017 May 26. Chronobiol Int. 2017. PMID: 28548897
Light intensity seemed to independently affect sleep as well, but to a lesser degree. Both light intensity and wavelength negatively affected morning attention. In sum, light wavelength seems to have a greater influence than light intensity on sleep and a wid …
Light intensity seemed to independently affect sleep as well, but to a lesser degree. Both light intensity and wavelength negatively …
Comparing the response to acute and chronic exposure to short wavelength lighting emitted from computer screens.
Green A, Cohen-Zion M, Haim A, Dagan Y. Green A, et al. Chronobiol Int. 2018 Jan;35(1):90-100. doi: 10.1080/07420528.2017.1387555. Epub 2017 Nov 7. Chronobiol Int. 2018. PMID: 29111816
As a result, humans are continuously exposed to unintentional artificial light. We explored the effects of acute and chronic exposure to artificial light at night (ALAN) via screen illumination on sleep, circadian rhythms, and related functional outcomes. Nineteen particip …
As a result, humans are continuously exposed to unintentional artificial light. We explored the effects of acute and chronic exposure …
Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation.
Schwimmer H, Metzer A, Pilosof Y, Szyf M, Machnes ZM, Fares F, Harel O, Haim A. Schwimmer H, et al. Chronobiol Int. 2014 Feb;31(1):144-50. doi: 10.3109/07420528.2013.842925. Epub 2013 Oct 16. Chronobiol Int. 2014. PMID: 24131150
Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tu …
Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coi …
Light and the City: Breast Cancer Risk Factors Differ Between Urban and Rural Women in Israel.
Keshet-Sitton A, Or-Chen K, Yitzhak S, Tzabary I, Haim A. Keshet-Sitton A, et al. Integr Cancer Ther. 2017 Jun;16(2):176-187. doi: 10.1177/1534735416660194. Epub 2016 Jul 20. Integr Cancer Ther. 2017. PMID: 27440788 Free PMC article.
We examined indoor and outdoor light habits of BC patients and controls that had lived in urban and rural areas in a 5-year period, 10 to 15 years before the time of the study. Individual data, night time sleeping habits and individual exposure to ALAN habits were collecte …
We examined indoor and outdoor light habits of BC patients and controls that had lived in urban and rural areas in a 5-year period, 1 …
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