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The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven't lived up to expectations, and where do we go from here?
Peters R, Dodge HH, James S, Jicha GA, Meyer PF, Richards M, Smith AD, Yassine HN, Abner E, Hainsworth AH, Kehoe PG, Beckett N, Anderson CS, Anstey KJ. Peters R, et al. Among authors: hainsworth ah. Alzheimers Dement. 2022 Mar;18(3):507-512. doi: 10.1002/alz.12393. Epub 2021 Nov 2. Alzheimers Dement. 2022. PMID: 34726352
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM. Horsburgh K, et al. Among authors: hainsworth ah. Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Clin Sci (Lond). 2018. PMID: 29712883 Free PMC article.
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings.
McFall A, Hietamies TM, Bernard A, Aimable M, Allan SM, Bath PM, Brezzo G, Carare RO, Carswell HV, Clarkson AN, Currie G, Farr TD, Fowler JH, Good M, Hainsworth AH, Hall C, Horsburgh K, Kalaria R, Kehoe P, Lawrence C, Macleod M, McColl BW, McNeilly A, Miller AA, Miners S, Mok V, O'Sullivan M, Platt B, Sena ES, Sharp M, Strangward P, Szymkowiak S, Touyz RM, Trueman RC, White C, McCabe C, Work LM, Quinn TJ. McFall A, et al. Among authors: hainsworth ah. J Cereb Blood Flow Metab. 2020 Jul;40(7):1402-1414. doi: 10.1177/0271678X20910552. Epub 2020 Mar 9. J Cereb Blood Flow Metab. 2020. PMID: 32151228 Free PMC article.
Dementia risk reduction: why haven't the pharmacological risk reduction trials worked? An in-depth exploration of seven established risk factors.
Peters R, Breitner J, James S, Jicha GA, Meyer PF, Richards M, Smith AD, Yassine HN, Abner E, Hainsworth AH, Kehoe PG, Beckett N, Weber C, Anderson C, Anstey KJ, Dodge HH. Peters R, et al. Among authors: hainsworth ah. Alzheimers Dement (N Y). 2021 Dec 8;7(1):e12202. doi: 10.1002/trc2.12202. eCollection 2021. Alzheimers Dement (N Y). 2021. PMID: 34934803 Free PMC article. Review.
The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment.
Pauls MMH, Binnie LR, Benjamin P, Betteridge S, Clarke B, Dhillon MK, Ghatala R, Hainsworth FAH, Howe FA, Khan U, Kruuse C, Madigan JB, Moynihan B, Patel B, Pereira AC, Rostrup E, Shtaya ABY, Spilling CA, Trippier S, Williams R, Young R, Barrick TR, Isaacs JD, Hainsworth AH. Pauls MMH, et al. Among authors: hainsworth ah, hainsworth fah. Alzheimers Dement. 2022 Dec;18(12):2393-2402. doi: 10.1002/alz.12559. Epub 2022 Feb 8. Alzheimers Dement. 2022. PMID: 35135037 Free PMC article. Clinical Trial.
White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.
Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. Alber J, et al. Among authors: hainsworth ah. Alzheimers Dement (N Y). 2019 Apr 9;5:107-117. doi: 10.1016/j.trci.2019.02.001. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31011621 Free PMC article. Review.
EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel.
Babiloni C, Arakaki X, Bonanni L, Bujan A, Carrillo MC, Del Percio C, Edelmayer RM, Egan G, Elahh FM, Evans A, Ferri R, Frisoni GB, Güntekin B, Hainsworth A, Hampel H, Jelic V, Jeong J, Kim DK, Kramberger M, Kumar S, Lizio R, Nobili F, Noce G, Puce A, Ritter P, Smit DJA, Soricelli A, Teipel S, Tucci F, Sachdev P, Valdes-Sosa M, Valdes-Sosa P, Vergallo A, Yener G. Babiloni C, et al. Neurobiol Aging. 2021 Jul;103:78-97. doi: 10.1016/j.neurobiolaging.2021.03.003. Epub 2021 Mar 10. Neurobiol Aging. 2021. PMID: 33845399 Review.
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98 results