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Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibody.
Klimpel GR, Eaves-Pyles T, Moen ST, Taormina J, Peterson JW, Chopra AK, Niesel DW, Carness P, Haithcoat JL, Kirtley M, Nasr AB. Klimpel GR, et al. Among authors: haithcoat jl. Vaccine. 2008 Dec 9;26(52):6874-82. doi: 10.1016/j.vaccine.2008.09.077. Epub 2008 Oct 16. Vaccine. 2008. PMID: 18930100 Free PMC article.
Critical role for serum opsonins and complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by human dendritic cells (DC): uptake of Francisella leads to activation of immature DC and intracellular survival of the bacteria.
Ben Nasr A, Haithcoat J, Masterson JE, Gunn JS, Eaves-Pyles T, Klimpel GR. Ben Nasr A, et al. J Leukoc Biol. 2006 Oct;80(4):774-86. doi: 10.1189/jlb.1205755. Epub 2006 Jul 20. J Leukoc Biol. 2006. PMID: 16857732