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Page 1
Discovery of a steroid 11α-hydroxylase from Rhizopus oryzae and its biotechnological application.
Petrič S, Hakki T, Bernhardt R, Zigon D, Crešnar B. Petrič S, et al. Among authors: hakki t. J Biotechnol. 2010 Nov;150(3):428-37. doi: 10.1016/j.jbiotec.2010.09.928. Epub 2010 Sep 17. J Biotechnol. 2010. PMID: 20850485
Coexpression of redox partners increases the hydrocortisone (cortisol) production efficiency in CYP11B1 expressing fission yeast Schizosaccharomyces pombe.
Hakki T, Zearo S, Drăgan CA, Bureik M, Bernhardt R. Hakki T, et al. J Biotechnol. 2008 Feb 1;133(3):351-9. doi: 10.1016/j.jbiotec.2007.06.022. Epub 2007 Jul 14. J Biotechnol. 2008. PMID: 17935813
Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations.
Tin MK, Hakki T, Bernhardt R. Tin MK, et al. Among authors: hakki t. J Steroid Biochem Mol Biol. 2011 Mar;124(1-2):31-7. doi: 10.1016/j.jsbmb.2011.01.002. Epub 2011 Jan 13. J Steroid Biochem Mol Biol. 2011. PMID: 21237269
ROS production by adrenodoxin does not cause apoptosis in fission yeast.
Derouet-Hümbert E, Drăgan CA, Hakki T, Bureik M. Derouet-Hümbert E, et al. Among authors: hakki t. Apoptosis. 2007 Dec;12(12):2135-42. doi: 10.1007/s10495-007-0133-1. Apoptosis. 2007. PMID: 17885803
Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols.
Lebouvier N, Pagniez F, Na YM, Shi D, Pinson P, Marchivie M, Guillon J, Hakki T, Bernhardt R, Yee SW, Simons C, Lézé MP, Hartmann RW, Mularoni A, Le Baut G, Krimm I, Abagyan R, Le Pape P, Le Borgne M. Lebouvier N, et al. Among authors: hakki t. Pharmaceuticals (Basel). 2020 Aug 8;13(8):186. doi: 10.3390/ph13080186. Pharmaceuticals (Basel). 2020. PMID: 32784450 Free PMC article.
The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Hakki T, Hübel K, Waldmann H, Bernhardt R. Hakki T, et al. J Steroid Biochem Mol Biol. 2011 May;125(1-2):120-8. doi: 10.1016/j.jsbmb.2010.12.011. Epub 2010 Dec 28. J Steroid Biochem Mol Biol. 2011. PMID: 21193036
CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets.
Hakki T, Bernhardt R. Hakki T, et al. Pharmacol Ther. 2006 Jul;111(1):27-52. doi: 10.1016/j.pharmthera.2005.07.006. Epub 2006 Jan 19. Pharmacol Ther. 2006. PMID: 16426683 Review.
The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status.
Obeid R, Hakki T, Jouma M, Herrmann W. Obeid R, et al. Among authors: hakki t. Clin Chem Lab Med. 2003 Oct;41(10):1357-62. doi: 10.1515/CCLM.2003.208. Clin Chem Lab Med. 2003. PMID: 14580166
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