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Pain versus analgesia: TAOK3 as a pharmacogene.
Cook-Sather SD, Li J, Hakonarson H. Cook-Sather SD, et al. Among authors: hakonarson h. Pain. 2017 Aug;158(8):1622-1623. doi: 10.1097/j.pain.0000000000000946. Pain. 2017. PMID: 28715357 Free PMC article. No abstract available.
TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
Cook-Sather SD, Li J, Goebel TK, Sussman EM, Rehman MA, Hakonarson H. Cook-Sather SD, et al. Among authors: hakonarson h. Pain. 2014 Sep;155(9):1773-1783. doi: 10.1016/j.pain.2014.05.032. Epub 2014 Jun 5. Pain. 2014. PMID: 24909733 Free PMC article.
Modulatory effects of TAOK3 variants on morphine requirement in acute postoperative pain: an early genome wide association study contribution to the field of pediatric pain.
Cook-Sather SD, Li J, Hakonarson H. Cook-Sather SD, et al. Among authors: hakonarson h. Pain. 2014 Nov;155(11):2435-2437. doi: 10.1016/j.pain.2014.09.010. Epub 2014 Nov 18. Pain. 2014. PMID: 25456570 No abstract available.
CYP2B6*6 or Not CYP2B6*6-That Remains a Question for Precision Medicine and Ketamine!
Cook-Sather SD, Adamson PC, Li J, Hakonarson H. Cook-Sather SD, et al. Among authors: hakonarson h. Anesthesiology. 2016 Dec;125(6):1085-1087. doi: 10.1097/ALN.0000000000001399. Anesthesiology. 2016. PMID: 27763886 Free PMC article. No abstract available.
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.
Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Smith AH, et al. Among authors: hakonarson h. Mol Psychiatry. 2017 Mar;22(3):346-352. doi: 10.1038/mp.2016.257. Epub 2017 Jan 24. Mol Psychiatry. 2017. PMID: 28115739 Free PMC article.
Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits.
Li J, Wei Z, Zhang J, Hakonarson H, Cook-Sather SD. Li J, et al. Among authors: hakonarson h. Pharmacogenomics J. 2019 Dec;19(6):570-581. doi: 10.1038/s41397-019-0074-4. Epub 2019 Feb 14. Pharmacogenomics J. 2019. PMID: 30760877 Free PMC article.
Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.
Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LO, Bradfield J, Schurmann C, Fine RS, Preuss MH, Kutalik Z, Wittemans LBL, Lu Y, Metz S, Willems SM, Li-Gao R, Grarup N, Wang S, Molnos S, Sandoval-Zárate AA, Nalls MA, Lange LA, Haesser J, Guo X, Lyytikäinen LP, Feitosa MF, Sitlani CM, Venturini C, Mahajan A, Kacprowski T, Wang CA, Chasman DI, Amin N, Broer L, Robertson N, Young KL, Allison M, Auer PL, Blüher M, Borja JB, Bork-Jensen J, Carrasquilla GD, Christofidou P, Demirkan A, Doege CA, Garcia ME, Graff M, Guo K, Hakonarson H, Hong J, Ida Chen YD, Jackson R, Jakupović H, Jousilahti P, Justice AE, Kähönen M, Kizer JR, Kriebel J, LeDuc CA, Li J, Lind L, Luan J, Mackey DA, Mangino M, Männistö S, Martin Carli JF, Medina-Gomez C, Mook-Kanamori DO, Morris AP, de Mutsert R, Nauck M, Prokic I, Pennell CE, Pradhan AD, Psaty BM, Raitakari OT, Scott RA, Skaaby T, Strauch K, Taylor KD, Teumer A, Uitterlinden AG, Wu Y, Yao J, Walker M, North KE, Kovacs P, Ikram MA, van Duijn CM, Ridker PM, Lye S, Homuth G, Ingelsson E, Spector TD, McKnight B, Province MA, Lehtimäki T, Adair LS, Rotter JI, Reiner AP, Wilson JG, Harris TB, Ripatti S, Grallert H, Meigs JB, Salomaa V, Hansen T, Willems van Dijk K, Wareham NJ, Grant SFA, Langenberg C, Frayling TM, Lindgren CM, Mohlke KL, Leibel RL, Loos RJF, Kilpeläinen TO. Yaghootkar H, et al. Among authors: hakonarson h. Diabetes. 2020 Dec;69(12):2806-2818. doi: 10.2337/db20-0070. Epub 2020 Sep 11. Diabetes. 2020. PMID: 32917775
Association of novel rare coding variants with juvenile idiopathic arthritis.
Meng X, Hou X, Wang P, Glessner JT, Qu HQ, March ME, Zhang S, Qi X, Zhu C, Nguyen K, Gao X, Li X, Liu Y, Zhou W, Zhang S, Li J, Sun Y, Yang J, Sleiman PMA, Xia Q, Hakonarson H, Li J. Meng X, et al. Among authors: hakonarson h. Ann Rheum Dis. 2021 Jan 6:annrheumdis-2020-218359. doi: 10.1136/annrheumdis-2020-218359. Online ahead of print. Ann Rheum Dis. 2021. PMID: 33408077
Assessing the functional consequence of loss of function variants using electronic medical record and large-scale genomics consortium efforts.
Sleiman P, Bradfield J, Mentch F, Almoguera B, Connolly J, Hakonarson H. Sleiman P, et al. Among authors: hakonarson h. Front Genet. 2014 Apr 29;5:105. doi: 10.3389/fgene.2014.00105. eCollection 2014. Front Genet. 2014. PMID: 24808909 Free PMC article.
Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes.
Almoguera B, Vazquez L, Connolly JJ, Bradfield J, Sleiman P, Keating B, Hakonarson H. Almoguera B, et al. Among authors: hakonarson h. Front Genet. 2014 May 12;5:96. doi: 10.3389/fgene.2014.00096. eCollection 2014. Front Genet. 2014. PMID: 24860591 Free PMC article.
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