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Gestational and Lactational Exposure to an Environmentally-relevant Mixture of Brominated Flame Retardants Down-regulates Junctional Proteins, Thyroid Hormone Receptor α1 Expression and the Proliferation-Apoptosis Balance in Mammary Glands Post Puberty.
Gouesse RJ, Lavoie M, Dianati E, Wade M, Hales B, Robaire B, Plante I. Gouesse RJ, et al. Among authors: hales b. Toxicol Sci. 2019 Jun 26;171(1):13-31. doi: 10.1093/toxsci/kfz147. Online ahead of print. Toxicol Sci. 2019. PMID: 31241157
In utero exposure to venlafaxine, a serotonin-norepinephrine reuptake inhibitor, increases cardiac anomalies and alters placental and heart serotonin signaling in the rat.
Laurent L, Huang C, Ernest SR, Berard A, Vaillancourt C, Hales BF. Laurent L, et al. Among authors: hales bf. Birth Defects Res A Clin Mol Teratol. 2016 Dec;106(12):1044-1055. doi: 10.1002/bdra.23537. Epub 2016 Jul 7. Birth Defects Res A Clin Mol Teratol. 2016. PMID: 27384265
Developmental toxicity of glyceryl trinitrate in quail embryos.
Bardai GK, Hales BF, Sunahara GI. Bardai GK, et al. Among authors: hales bf. Birth Defects Res A Clin Mol Teratol. 2011 Apr;91(4):230-40. doi: 10.1002/bdra.20801. Epub 2011 Apr 6. Birth Defects Res A Clin Mol Teratol. 2011. PMID: 21472843
The oxidative stress response is region specific in organogenesis stage mouse embryos exposed to 5-bromo-2'-deoxyuridine.
Gnanabakthan N, Hales BF. Gnanabakthan N, et al. Among authors: hales bf. Birth Defects Res A Clin Mol Teratol. 2009 Mar;85(3):202-10. doi: 10.1002/bdra.20543. Birth Defects Res A Clin Mol Teratol. 2009. PMID: 19161159
BACKGROUND: The exposure of mouse embryos to 5-bromo-2'-deoxyuridine (BrdU), a model teratogen, generates oxidative stress, induces c-Fos dependent activator protein-1 (AP-1) DNA binding activity, and causes skeletal malformations (Sahambi and Hales, 2006). ...
BACKGROUND: The exposure of mouse embryos to 5-bromo-2'-deoxyuridine (BrdU), a model teratogen, generates oxidative stress, induces c-Fos de …
Deprenyl enhances the teratogenicity of hydroxyurea in organogenesis stage mouse embryos.
Schlisser AE, Hales BF. Schlisser AE, et al. Among authors: hales bf. Toxicol Sci. 2013 Aug;134(2):391-9. doi: 10.1093/toxsci/kft115. Epub 2013 May 21. Toxicol Sci. 2013. PMID: 23696560 Free PMC article.
Glyceryl trinitrate metabolism in the quail embryo by the glutathione S-transferases leads to a perturbation in redox status and embryotoxicity.
Bardai GK, Hales BF, Sunahara GI. Bardai GK, et al. Among authors: hales bf. Comp Biochem Physiol B Biochem Mol Biol. 2013 Jul;165(3):153-64. doi: 10.1016/j.cbpb.2013.04.001. Epub 2013 Apr 12. Comp Biochem Physiol B Biochem Mol Biol. 2013. PMID: 23587908
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