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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.
Burbelo PD, Drechsel D, Hall A. Burbelo PD, et al. Among authors: hall a. J Biol Chem. 1995 Dec 8;270(49):29071-4. doi: 10.1074/jbc.270.49.29071. J Biol Chem. 1995. PMID: 7493928
Here we have used a motif-based search method to identify putative effector proteins for Rac and Cdc42. A search of the GenBankTM data base for similarity with the minimum Cdc42/Rac interactive binding (CRIB) region of a potential effector protein p65PAK has …
Here we have used a motif-based search method to identify putative effector proteins for Rac and Cdc42. A search of the GenBan …
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis.
Jaffe AB, Kaji N, Durgan J, Hall A. Jaffe AB, et al. Among authors: hall a. J Cell Biol. 2008 Nov 17;183(4):625-33. doi: 10.1083/jcb.200807121. Epub 2008 Nov 10. J Cell Biol. 2008. PMID: 19001128 Free PMC article.
The establishment of apical-basal polarity within a single cell and throughout a growing tissue is a key feature of epithelial morphogenesis. To examine the underlying mechanisms, the human intestinal epithelial cell line Caco-2 was grown in a three-di …
The establishment of apical-basal polarity within a single cell and throughout a growing tissue is a key feature of epi …
Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization.
Etienne-Manneville S, Manneville JB, Nicholls S, Ferenczi MA, Hall A. Etienne-Manneville S, et al. Among authors: hall a. J Cell Biol. 2005 Sep 12;170(6):895-901. doi: 10.1083/jcb.200412172. J Cell Biol. 2005. PMID: 16157700 Free PMC article.
Cell polarization is essential in a wide range of biological processes such as morphogenesis, asymmetric division, and directed migration. ...
Cell polarization is essential in a wide range of biological processes such as morphogenesis, asymmetric division, and directed migra …
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity.
Etienne-Manneville S, Hall A. Etienne-Manneville S, et al. Among authors: hall a. Nature. 2003 Feb 13;421(6924):753-6. doi: 10.1038/nature01423. Epub 2003 Jan 29. Nature. 2003. PMID: 12610628
Cell polarity is a fundamental property of all cells. In higher eukaryotes, the small GTPase Cdc42, acting through a Par6-atypical protein kinase C (aPKC) complex, is required to establish cellular asymmetry during epithelial morphogenesis, asymmetric cell division …
Cell polarity is a fundamental property of all cells. In higher eukaryotes, the small GTPase Cdc42, acting through a Par6-atyp …
Cell migration: Rho GTPases lead the way.
Raftopoulou M, Hall A. Raftopoulou M, et al. Among authors: hall a. Dev Biol. 2004 Jan 1;265(1):23-32. doi: 10.1016/j.ydbio.2003.06.003. Dev Biol. 2004. PMID: 14697350 Review.
Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and ves …
Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are b …
Rho GTPases: biochemistry and biology.
Jaffe AB, Hall A. Jaffe AB, et al. Among authors: hall a. Annu Rev Cell Dev Biol. 2005;21:247-69. doi: 10.1146/annurev.cellbio.21.020604.150721. Annu Rev Cell Dev Biol. 2005. PMID: 16212495 Review.
Through a series of complex biochemical networks, these highly conserved molecular switches control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division. In the first part of this re …
Through a series of complex biochemical networks, these highly conserved molecular switches control some of the most fundamental proc …
Snails, Swiss, and serum: the solution for Rac 'n' Rho.
Ridley AJ, Hall A. Ridley AJ, et al. Among authors: hall a. Cell. 2004 Jan 23;116(2 Suppl):S23-5, 2 p following S25. doi: 10.1016/s0092-8674(04)00048-0. Cell. 2004. PMID: 15055577 No abstract available.
The activity of the plexin-A1 receptor is regulated by Rac.
Turner LJ, Nicholls S, Hall A. Turner LJ, et al. Among authors: hall a. J Biol Chem. 2004 Aug 6;279(32):33199-205. doi: 10.1074/jbc.M402943200. Epub 2004 Jun 8. J Biol Chem. 2004. PMID: 15187088
Sema3A/Plexin-A1-induced growth cone collapse, for example, requires Rac activity, which is a surprising result given that this GTPase is usually associated with membrane protrusions. ...However, collapse induced by a constitutively activated version of Plexin-A1 do …
Sema3A/Plexin-A1-induced growth cone collapse, for example, requires Rac activity, which is a surprising result given that this GTPas …
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity.
Schlessinger K, McManus EJ, Hall A. Schlessinger K, et al. Among authors: hall a. J Cell Biol. 2007 Jul 30;178(3):355-61. doi: 10.1083/jcb.200701083. Epub 2007 Jul 23. J Cell Biol. 2007. PMID: 17646398 Free PMC article.
We previously reported that centrosomal reorientation and microtubule polarization depend on a Cdc42-regulated signal transduction pathway involving activation of the Par6/aPKC complex followed by inhibition of GSK-3beta and accumulation of the adenomatous polyposis coli ( …
We previously reported that centrosomal reorientation and microtubule polarization depend on a Cdc42-regulated signal transduction pa …
Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.
Schmidt A, Durgan J, Magalhaes A, Hall A. Schmidt A, et al. Among authors: hall a. EMBO J. 2007 Mar 21;26(6):1624-36. doi: 10.1038/sj.emboj.7601637. Epub 2007 Mar 1. EMBO J. 2007. PMID: 17332740 Free PMC article.
We now report that PRK2/PKN2, a Ser/Thr kinase and Rho/Rac effector protein, is an essential regulator of both entry into mitosis and exit from cytokinesis in HeLa S3 cells. ...
We now report that PRK2/PKN2, a Ser/Thr kinase and Rho/Rac effector protein, is an essential regulator of both entry into mitosis and …
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