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Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.
Ridley AJ, Hall A. Ridley AJ, et al. Among authors: hall a. EMBO J. 1994 Jun 1;13(11):2600-10. EMBO J. 1994. PMID: 7516876 Free PMC article.
Lysophosphatidic acid (LPA) and bombesin rapidly stimulate the formation of focal adhesions and actin stress fibres in serum-starved Swiss 3T3 fibroblasts, a process regulated by the small GTP binding protein Rho. ...This suggests a model where Rho-induced activatio …
Lysophosphatidic acid (LPA) and bombesin rapidly stimulate the formation of focal adhesions and actin stress fibres in serum-starved Swiss 3 …
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.
Durgan J, Tao G, Walters MS, Florey O, Schmidt A, Arbelaez V, Rosen N, Crystal RG, Hall A. Durgan J, et al. Among authors: hall a. EMBO Rep. 2015 Jan;16(1):87-96. doi: 10.15252/embr.201439218. Epub 2014 Nov 13. EMBO Rep. 2015. PMID: 25394671 Free PMC article.
The human airway is lined with respiratory epithelial cells, which create a critical barrier through the formation of apical tight junctions. ...EMP1 is indispensable for tight junction formation and function in 16HBE cells and in a human airway basal progenitor-lik …
The human airway is lined with respiratory epithelial cells, which create a critical barrier through the formation of apical tight ju …
p27Kip1 modulates cell migration through the regulation of RhoA activation.
Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM. Besson A, et al. Among authors: hall a. Genes Dev. 2004 Apr 15;18(8):862-76. doi: 10.1101/gad.1185504. Epub 2004 Apr 12. Genes Dev. 2004. PMID: 15078817 Free PMC article.
The tumor suppressor p27(Kip1) is an inhibitor of cyclin/cyclin-dependent kinase (CDK) complexes and plays a crucial role in cell cycle regulation. ...Together, the data suggest a novel role for p27(Kip1) in regulating cell migration via modulation of the Rho pathwa …
The tumor suppressor p27(Kip1) is an inhibitor of cyclin/cyclin-dependent kinase (CDK) complexes and plays a crucial role in cell cyc …
Cell migration: Rho GTPases lead the way.
Raftopoulou M, Hall A. Raftopoulou M, et al. Among authors: hall a. Dev Biol. 2004 Jan 1;265(1):23-32. doi: 10.1016/j.ydbio.2003.06.003. Dev Biol. 2004. PMID: 14697350 Review.
Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and ves …
Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are b …
Rho GTPases: biochemistry and biology.
Jaffe AB, Hall A. Jaffe AB, et al. Among authors: hall a. Annu Rev Cell Dev Biol. 2005;21:247-69. doi: 10.1146/annurev.cellbio.21.020604.150721. Annu Rev Cell Dev Biol. 2005. PMID: 16212495 Review.
Through a series of complex biochemical networks, these highly conserved molecular switches control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division. In the first part of this re …
Through a series of complex biochemical networks, these highly conserved molecular switches control some of the most fundamental proc …
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity.
Schlessinger K, McManus EJ, Hall A. Schlessinger K, et al. Among authors: hall a. J Cell Biol. 2007 Jul 30;178(3):355-61. doi: 10.1083/jcb.200701083. Epub 2007 Jul 23. J Cell Biol. 2007. PMID: 17646398 Free PMC article.
We previously reported that centrosomal reorientation and microtubule polarization depend on a Cdc42-regulated signal transduction pathway involving activation of the Par6/aPKC complex followed by inhibition of GSK-3beta and accumulation of the adenomatous polyposis coli ( …
We previously reported that centrosomal reorientation and microtubule polarization depend on a Cdc42-regulated signal transduction pa …
Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.
Schmidt A, Durgan J, Magalhaes A, Hall A. Schmidt A, et al. Among authors: hall a. EMBO J. 2007 Mar 21;26(6):1624-36. doi: 10.1038/sj.emboj.7601637. Epub 2007 Mar 1. EMBO J. 2007. PMID: 17332740 Free PMC article.
We now report that PRK2/PKN2, a Ser/Thr kinase and Rho/Rac effector protein, is an essential regulator of both entry into mitosis and exit from cytokinesis in HeLa S3 cells. ...
We now report that PRK2/PKN2, a Ser/Thr kinase and Rho/Rac effector protein, is an essential regulator of both entry into mitosis and …
Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways.
Cau J, Hall A. Cau J, et al. Among authors: hall a. J Cell Sci. 2005 Jun 15;118(Pt 12):2579-87. doi: 10.1242/jcs.02385. Epub 2005 May 31. J Cell Sci. 2005. PMID: 15928049
Cdc42, a Rho family GTPase, is a key regulator of cell polarity. In Saccharomyces cerevisiae, it is required for polarized bud formation and pheromone gradient sensing, while in higher eukaryotes, it participates in asymmetric cell division, directional sensing duri …
Cdc42, a Rho family GTPase, is a key regulator of cell polarity. In Saccharomyces cerevisiae, it is required for polarized bud …
Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho.
Jaffe AB, Hall A, Schmidt A. Jaffe AB, et al. Among authors: hall a. Curr Biol. 2005 Mar 8;15(5):405-12. doi: 10.1016/j.cub.2004.12.082. Curr Biol. 2005. PMID: 15753034
BACKGROUND: Rho is a small GTPase that controls signal transduction pathways in response to a large number of extracellular stimuli. With over 15 potential Rho target proteins identified to date, however, it is not clear how distinct signaling outputs can be generat …
BACKGROUND: Rho is a small GTPase that controls signal transduction pathways in response to a large number of extracellular st …
Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways.
Jaffe AB, Aspenström P, Hall A. Jaffe AB, et al. Among authors: hall a. Mol Cell Biol. 2004 Feb;24(4):1736-46. doi: 10.1128/mcb.24.4.1736-1746.2004. Mol Cell Biol. 2004. PMID: 14749388 Free PMC article.
Rho family GTPases act as molecular switches to control a variety of cellular responses, including cytoskeletal rearrangements, changes in gene expression, and cell transformation. ...A mutant hCNK1, which is unable to bind to Rho, or depletion of endogenous hCNK1 b …
Rho family GTPases act as molecular switches to control a variety of cellular responses, including cytoskeletal rearrangements, chang …
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