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Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy.
Martinsson T, Eriksson T, Abrahamsson J, Caren H, Hansson M, Kogner P, Kamaraj S, Schönherr C, Weinmar J, Ruuth K, Palmer RH, Hallberg B. Martinsson T, et al. Among authors: hallberg b. Cancer Res. 2011 Jan 1;71(1):98-105. doi: 10.1158/0008-5472.CAN-10-2366. Epub 2010 Nov 8. Cancer Res. 2011. PMID: 21059859
The neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo.
Schönherr C, Ruuth K, Eriksson T, Yamazaki Y, Ottmann C, Combaret V, Vigny M, Kamaraj S, Palmer RH, Hallberg B. Schönherr C, et al. Among authors: hallberg b. Transl Oncol. 2011 Aug;4(4):258-65. doi: 10.1593/tlo.11139. Epub 2011 Aug 1. Transl Oncol. 2011. PMID: 21804922 Free PMC article.
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