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27 results
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Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs.
Hallifax D, Houston JB. Hallifax D, et al. J Pharm Sci. 2012 Aug;101(8):2645-52. doi: 10.1002/jps.23202. Epub 2012 Jun 14. J Pharm Sci. 2012. PMID: 22700322
Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes.
Jones HM, Hallifax D, Houston JB. Jones HM, et al. Among authors: hallifax d. Drug Metab Dispos. 2004 May;32(5):572-80. doi: 10.1124/dmd.32.5.572. Drug Metab Dispos. 2004. PMID: 15100181
Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.
Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G. Collett A, et al. Among authors: hallifax d. Pharm Res. 2004 May;21(5):819-26. doi: 10.1023/b:pham.0000026434.82855.69. Pharm Res. 2004. PMID: 15180340
Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.
Galetin A, Brown C, Hallifax D, Ito K, Houston JB. Galetin A, et al. Among authors: hallifax d. Drug Metab Dispos. 2004 Dec;32(12):1411-20. doi: 10.1124/dmd.104.000844. Epub 2004 Sep 1. Drug Metab Dispos. 2004. PMID: 15342470
CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions.
Galetin A, Ito K, Hallifax D, Houston JB. Galetin A, et al. Among authors: hallifax d. J Pharmacol Exp Ther. 2005 Jul;314(1):180-90. doi: 10.1124/jpet.104.082826. Epub 2005 Mar 22. J Pharmacol Exp Ther. 2005. PMID: 15784650
Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.
Ito K, Hallifax D, Obach RS, Houston JB. Ito K, et al. Among authors: hallifax d. Drug Metab Dispos. 2005 Jun;33(6):837-44. doi: 10.1124/dmd.104.003715. Drug Metab Dispos. 2005. PMID: 15897600
Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines.
Hallifax D, Rawden HC, Hakooz N, Houston JB. Hallifax D, et al. Drug Metab Dispos. 2005 Dec;33(12):1852-8. doi: 10.1124/dmd.105.005389. Epub 2005 Sep 20. Drug Metab Dispos. 2005. PMID: 16174807
Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans.
Rawden HC, Carlile DJ, Tindall A, Hallifax D, Galetin A, Ito K, Houston JB. Rawden HC, et al. Among authors: hallifax d. Xenobiotica. 2005 Jun;35(6):603-25. doi: 10.1080/00498250500162870. Xenobiotica. 2005. PMID: 16192111
Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance.
Hallifax D, Houston JB. Hallifax D, et al. Drug Metab Dispos. 2006 Nov;34(11):1829-36. doi: 10.1124/dmd.106.010413. Epub 2006 Aug 1. Drug Metab Dispos. 2006. PMID: 16882765
Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.
Brown HS, Galetin A, Hallifax D, Houston JB. Brown HS, et al. Among authors: hallifax d. Clin Pharmacokinet. 2006;45(10):1035-50. doi: 10.2165/00003088-200645100-00006. Clin Pharmacokinet. 2006. PMID: 16984215
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