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Year Number of Results
1993 1
2000 1
2001 1
2003 1
2004 2
2009 1
2011 1
2014 2
2015 1
2018 1
2019 1
2024 1
2026 4

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17 results

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Page 1
Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models.
García-Rodríguez I, Moreni G, Capendale PE, Mulder L, Aknouch I, Vieira de Sá R, Johannesson N, Freeze E, van Eijk H, Koen G, Wolthers KC, Pajkrt D, Sridhar A, Calitz C. García-Rodríguez I, et al. Antiviral Res. 2024 Feb;222:105798. doi: 10.1016/j.antiviral.2024.105798. Epub 2024 Jan 6. Antiviral Res. 2024. PMID: 38190972 Free article.
Halofuginone hydrobromide has shown potent antiviral efficacy against a variety of viruses such as SARS-CoV-2, dengue, or chikungunya virus, and has, therefore, been hypothesized to have broad-spectrum antiviral activity. In this paper, we tested this broad-s …
Halofuginone hydrobromide has shown potent antiviral efficacy against a variety of viruses such as SARS-CoV-2, dengue, or chik …
Recent advances in antiviral drugs for Chikungunya virus (CHIKV): Targets, mechanisms, and development strategies.
Jiang X, Zhao Y, Lu H, Li K, Gao H. Jiang X, et al. Acta Pharm Sin B. 2026 Jun;16(6):3257-3291. doi: 10.1016/j.apsb.2026.03.044. Epub 2026 Mar 30. Acta Pharm Sin B. 2026. PMID: 42368589 Free PMC article. Review.
This review systematically summarizes recent progress in antiviral research on CHIKV, focusing on key target proteins in the viral life cycle, such as non-structural proteins nsP1, nsP2, nsP3, nsP4, and structural protein E1-E2 complexes, as well as the mechanisms of actio …
This review systematically summarizes recent progress in antiviral research on CHIKV, focusing on key target proteins in the viral li …
Halofuginone suppresses HSV-2 through direct viral inhibition and host ProRS inhibition.
Pan Z, Chen Z, Huang X, Lin Y, Li L, Liu S, Tan S. Pan Z, et al. Biochem Pharmacol. 2026 Sep;251(Pt 1):118061. doi: 10.1016/j.bcp.2026.118061. Epub 2026 May 14. Biochem Pharmacol. 2026. PMID: 42140445
Because current therapy still relies largely on nucleoside analogues and resistant isolates continue to emerge, alternative antiviral strategies are needed. In this study, halofuginone (HF), a halogenated analogue of the febrifugine scaffold, inhibited both wild-typ …
Because current therapy still relies largely on nucleoside analogues and resistant isolates continue to emerge, alternative antiviral …
Hepatitis C and liver fibrosis.
Schuppan D, Krebs A, Bauer M, Hahn EG. Schuppan D, et al. Cell Death Differ. 2003 Jan;10 Suppl 1:S59-67. doi: 10.1038/sj.cdd.4401163. Cell Death Differ. 2003. PMID: 12655347 Review.
This knowledge will make it possible to identify those patients who are most likely to progress and who need antiviral or antifibrotic therapies most urgently. However, even the best available treatment, the combination of pegylated interferon and ribavirin, which is costl …
This knowledge will make it possible to identify those patients who are most likely to progress and who need antiviral or antifibroti …
Novel therapy in the treatment of scleroderma.
Wigley FM, Sule SD. Wigley FM, et al. Expert Opin Investig Drugs. 2001 Jan;10(1):31-48. doi: 10.1517/13543784.10.1.31. Expert Opin Investig Drugs. 2001. PMID: 11116279 Review.
Wound-healing modulation in upper airway stenosis-Myths and facts.
Hirshoren N, Eliashar R. Hirshoren N, et al. Head Neck. 2009 Jan;31(1):111-26. doi: 10.1002/hed.20925. Head Neck. 2009. PMID: 18767172 Review.
The relevant Pubmed and Ovid databases from 1960 to 2007 were systematically searched. Several modulating agents have been tested. Most of them were poorly investigated. Three modalities were thoroughly studied-steroids and antibiotics, mitomycin, and antireflux medication …
The relevant Pubmed and Ovid databases from 1960 to 2007 were systematically searched. Several modulating agents have been tested. Mo …
Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone.
Nagler A, Ohana M, Shibolet O, Shapira MY, Alper R, Vlodavsky I, Pines M, Ilan Y. Nagler A, et al. Eur J Cancer. 2004 Jun;40(9):1397-403. doi: 10.1016/j.ejca.2003.11.036. Eur J Cancer. 2004. PMID: 15177499
Halofuginone also suppresses extracellular matrix deposition and fibroblast proliferation. ...Halofuginone treatment induced almost complete tumour suppression in treated mice. Mortality rates were 10% and 50%, in halofuginone-treated and control mice, respec …
Halofuginone also suppresses extracellular matrix deposition and fibroblast proliferation. ...Halofuginone treatment induced a …
Potential nonhormonal therapeutics for medical treatment of leiomyomas.
Young SL, Al-Hendy A, Copland JA. Young SL, et al. Semin Reprod Med. 2004 May;22(2):121-30. doi: 10.1055/s-2004-828618. Semin Reprod Med. 2004. PMID: 15164307 Review.
Other laboratories have evaluated pirfenidone, halofuginone, heparin, and interferon-alpha (IFN-alpha). Recent work in our laboratory suggests potential use of two additional classes of compounds, thiazolidinediones and tocopherol analogs. ...
Other laboratories have evaluated pirfenidone, halofuginone, heparin, and interferon-alpha (IFN-alpha). Recent work in our laboratory …
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.
Hwang J, Jiang A, Fikrig E. Hwang J, et al. Antiviral Res. 2019 Jan;161:163-168. doi: 10.1016/j.antiviral.2018.11.017. Epub 2018 Dec 3. Antiviral Res. 2019. PMID: 30521835 Free PMC article.
Due to the increasing likelihood of co-circulation and co-infection with viruses, we aimed to identify a pharmacologically targetable host factor that can inhibit multiple viruses and show that a potent antagonist of prolyl tRNA synthetase (halofuginone) suppresses both Ch …
Due to the increasing likelihood of co-circulation and co-infection with viruses, we aimed to identify a pharmacologically targetable host f …
[Infectious diarrhea of calves: therapeutic and preventive possibilities based on etiological, pathophysiological and immunological data].
Vanopdenbosch E, Pohl P. Vanopdenbosch E, et al. Tijdschr Diergeneeskd. 1993 Nov 15;118(22):731-4. Tijdschr Diergeneeskd. 1993. PMID: 8266306 Review. Dutch.
To obtain a maximum level of E.coli antibodies in colostrum, the last vaccination has to be administered at least 8 weeks before parturition. Prolonged excretion of antiviral antibodies in the milk for several weeks, can be achieved by a 'priming' vaccination with an adjuv …
To obtain a maximum level of E.coli antibodies in colostrum, the last vaccination has to be administered at least 8 weeks before parturition …
17 results