Halpert JR - Search Results

1

Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Duignan DB, Sipes IG, Leonard TB, Halpert JR. Duignan DB, et al. Among authors: halpert jr. Arch Biochem Biophys. 1987 Jun;255(2):290-303. doi: 10.1016/0003-9861(87)90396-1. Arch Biochem Biophys. 1987. PMID: 3109323

2

Functional role of residues in the helix B' region of cytochrome P450 2B1.

Honma W, Li W, Liu H, Scott EE, Halpert JR. Honma W, et al. Among authors: halpert jr. Arch Biochem Biophys. 2005 Mar 1;435(1):157-65. doi: 10.1016/j.abb.2004.12.014. Arch Biochem Biophys. 2005. PMID: 15680917

3

Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.

Davydov DR, Davydova NY, Tsalkova TN, Halpert JR. Davydov DR, et al. Among authors: halpert jr. Arch Biochem Biophys. 2008 Mar 15;471(2):134-45. doi: 10.1016/j.abb.2008.01.001. Epub 2008 Jan 11. Arch Biochem Biophys. 2008. PMID: 18206979 Free PMC article.

4

Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.

Fernando H, Halpert JR, Davydov DR. Fernando H, et al. Among authors: halpert jr. Arch Biochem Biophys. 2008 Mar 1;471(1):20-31. doi: 10.1016/j.abb.2007.11.020. Epub 2007 Dec 7. Arch Biochem Biophys. 2008. PMID: 18086551 Free PMC article.

5

Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.

Fernando H, Davydov DR, Chin CC, Halpert JR. Fernando H, et al. Among authors: halpert jr. Arch Biochem Biophys. 2007 Apr 1;460(1):129-40. doi: 10.1016/j.abb.2006.12.025. Epub 2007 Jan 12. Arch Biochem Biophys. 2007. PMID: 17274942 Free PMC article.

6

Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.

Hernandez CE, Kumar S, Liu H, Halpert JR. Hernandez CE, et al. Among authors: halpert jr. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7. doi: 10.1016/j.abb.2006.08.024. Epub 2006 Sep 25. Arch Biochem Biophys. 2006. PMID: 17027909 Free PMC article.

7

An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

Davydov DR, Botchkareva AE, Kumar S, He YQ, Halpert JR. Davydov DR, et al. Among authors: halpert jr. Biochemistry. 2004 Jun 1;43(21):6475-85. doi: 10.1021/bi036260l. Biochemistry. 2004. PMID: 15157081

8

Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling.

He YA, Roussel F, Halpert JR. He YA, et al. Among authors: halpert jr. Arch Biochem Biophys. 2003 Jan 1;409(1):92-101. doi: 10.1016/s0003-9861(02)00484-8. Arch Biochem Biophys. 2003. PMID: 12464248

9

Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.

Domanski TL, He YA, Khan KK, Roussel F, Wang Q, Halpert JR. Domanski TL, et al. Among authors: halpert jr. Biochemistry. 2001 Aug 28;40(34):10150-60. doi: 10.1021/bi010758a. Biochemistry. 2001. PMID: 11513592

10

The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins.

Domanski TL, He YQ, Scott EE, Wang Q, Halpert JR. Domanski TL, et al. Among authors: halpert jr. Arch Biochem Biophys. 2001 Oct 1;394(1):21-8. doi: 10.1006/abbi.2001.2504. Arch Biochem Biophys. 2001. PMID: 11566023

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