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Lysophosphatidylcholine increases neutrophil bactericidal activity by enhancement of azurophil granule-phagosome fusion via glycine.GlyR alpha 2/TRPM2/p38 MAPK signaling.
Hong CW, Kim TK, Ham HY, Nam JS, Kim YH, Zheng H, Pang B, Min TK, Jung JS, Lee SN, Cho HJ, Kim EJ, Hong IH, Kang TC, Lee J, Oh SB, Jung SJ, Kim SJ, Song DK. Hong CW, et al. Among authors: ham hy. J Immunol. 2010 Apr 15;184(8):4401-13. doi: 10.4049/jimmunol.0902814. Epub 2010 Mar 17. J Immunol. 2010. PMID: 20237295
Lys1110 of TRPM2 is critical for channel activation.
Kim TK, Nam JH, Ahn WG, Kim NH, Ham HY, Hong CW, Nam JS, Lee J, Huh SO, So I, Kim SJ, Song DK. Kim TK, et al. Among authors: ham hy. Biochem J. 2013 Nov 1;455(3):319-27. doi: 10.1042/BJ20130303. Biochem J. 2013. PMID: 23957292