Hamatake R - Search Results

1

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.

Cheney IW, Yan S, Appleby T, Walker H, Vo T, Yao N, Hamatake R, Hong Z, Wu JZ. Cheney IW, et al. Among authors: hamatake r. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83. doi: 10.1016/j.bmcl.2006.12.086. Epub 2007 Jan 4. Bioorg Med Chem Lett. 2007. PMID: 17251021

2

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.

Varaprasad CV, Barawkar D, El Abdellaoui H, Chakravarty S, Allan M, Chen H, Zhang W, Wu JZ, Tam R, Hamatake R, Lang S, Hong Z. Varaprasad CV, et al. Among authors: hamatake r. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. doi: 10.1016/j.bmcl.2006.05.019. Epub 2006 May 24. Bioorg Med Chem Lett. 2006. PMID: 16725322

3

Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase.

De La Rosa M, Kim HW, Gunic E, Jenket C, Boyle U, Koh YH, Korboukh I, Allan M, Zhang W, Chen H, Xu W, Nilar S, Yao N, Hamatake R, Lang SA, Hong Z, Zhang Z, Girardet JL. De La Rosa M, et al. Among authors: hamatake r. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4444-9. doi: 10.1016/j.bmcl.2006.06.048. Epub 2006 Jun 27. Bioorg Med Chem Lett. 2006. PMID: 16806925

4

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.

Yan S, Appleby T, Larson G, Wu JZ, Hamatake R, Hong Z, Yao N. Yan S, et al. Among authors: hamatake r. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5888-91. doi: 10.1016/j.bmcl.2006.08.056. Epub 2006 Aug 24. Bioorg Med Chem Lett. 2006. PMID: 16934455

5

Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.

El Abdellaoui H, Varaprasad CV, Barawkar D, Chakravarty S, Maderna A, Tam R, Chen H, Allan M, Wu JZ, Appleby T, Yan S, Zhang W, Lang S, Yao N, Hamatake R, Hong Z. El Abdellaoui H, et al. Among authors: hamatake r. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5561-6. doi: 10.1016/j.bmcl.2006.08.048. Epub 2006 Aug 24. Bioorg Med Chem Lett. 2006. PMID: 16934458

6

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure.

Yan S, Larson G, Wu JZ, Appleby T, Ding Y, Hamatake R, Hong Z, Yao N. Yan S, et al. Among authors: hamatake r. Bioorg Med Chem Lett. 2007 Jan 1;17(1):63-7. doi: 10.1016/j.bmcl.2006.09.095. Epub 2006 Oct 4. Bioorg Med Chem Lett. 2007. PMID: 17049849

7

Isothiazoles as active-site inhibitors of HCV NS5B polymerase.

Yan S, Appleby T, Gunic E, Shim JH, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N. Yan S, et al. Among authors: hamatake r. Bioorg Med Chem Lett. 2007 Jan 1;17(1):28-33. doi: 10.1016/j.bmcl.2006.10.002. Epub 2006 Oct 5. Bioorg Med Chem Lett. 2007. PMID: 17049853

8

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study.

Yan S, Appleby T, Larson G, Wu JZ, Hamatake RK, Hong Z, Yao N. Yan S, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1991-5. doi: 10.1016/j.bmcl.2007.01.024. Epub 2007 Jan 19. Bioorg Med Chem Lett. 2007. PMID: 17276060

9

6-Hydrazinopurine 2'-methyl ribonucleosides and their 5'-monophosphate prodrugs as potent hepatitis C virus inhibitors.

Gunic E, Chow S, Rong F, Ramasamy K, Raney A, Li DY, Huang J, Hamatake RK, Hong Z, Girardet JL. Gunic E, et al. Bioorg Med Chem Lett. 2007 May 1;17(9):2456-8. doi: 10.1016/j.bmcl.2007.02.029. Epub 2007 Feb 14. Bioorg Med Chem Lett. 2007. PMID: 17331718

10

Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication.

Gunic E, Girardet JL, Ramasamy K, Stoisavljevic-Petkov V, Chow S, Yeh LT, Hamatake RK, Raney A, Hong Z. Gunic E, et al. Bioorg Med Chem Lett. 2007 May 1;17(9):2452-5. doi: 10.1016/j.bmcl.2007.02.030. Epub 2007 Feb 14. Bioorg Med Chem Lett. 2007. PMID: 17331721

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