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Evaluation of the global impacts of mitigation on persistent, bioaccumulative and toxic pollutants in marine fish.
Bonito LT, Hamdoun A, Sandin SA. Bonito LT, et al. PeerJ. 2016 Jan 28;4:e1573. doi: 10.7717/peerj.1573. eCollection 2016. PeerJ. 2016. PMID: 26839747 Free PMC article.
Although persistent, bioaccumulative and toxic pollutants (PBTs) are well-studied individually, their distribution and variability on a global scale are largely unknown, particularly in marine fish. ...We further examined patterns of change in PBT concentration as a
Although persistent, bioaccumulative and toxic pollutants (PBTs) are well-studied individually, their distribution and variability on a
Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure.
Nicklisch SC, Rees SD, McGrath AP, Gökirmak T, Bonito LT, Vermeer LM, Cregger C, Loewen G, Sandin S, Chang G, Hamdoun A. Nicklisch SC, et al. Sci Adv. 2016 Apr 15;2(4):e1600001. doi: 10.1126/sciadv.1600001. eCollection 2016 Apr. Sci Adv. 2016. PMID: 27152359 Free PMC article.
The world's oceans are a global reservoir of persistent organic pollutants to which humans and other animals are exposed. Although it is well known that these pollutants are potentially hazardous to human and environmental health, their impacts remain incompletely understo …
The world's oceans are a global reservoir of persistent organic pollutants to which humans and other animals are exposed. Although it …
Mercury levels of yellowfin tuna (Thunnus albacares) are associated with capture location.
Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. Nicklisch SCT, et al. Environ Pollut. 2017 Oct;229:87-93. doi: 10.1016/j.envpol.2017.05.070. Epub 2017 May 31. Environ Pollut. 2017. PMID: 28577385 Free PMC article.
Less accounted for is the variation within species, and the potential role of the geographic origin of a fish in determining its mercury level. ...Mean mercury levels were only weakly associated with fish size (R(2) < 0.1461) or lipid content (R(2) < 0.00007) but var …
Less accounted for is the variation within species, and the potential role of the geographic origin of a fish in determining its merc …
Geographic Differences in Persistent Organic Pollutant Levels of Yellowfin Tuna.
Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. Nicklisch SCT, et al. Environ Health Perspect. 2017 Jun 26;125(6):067014. doi: 10.1289/EHP518. Environ Health Perspect. 2017. PMID: 28686554 Free PMC article.
BACKGROUND: Fish are a source of persistent organic pollutants (POPs) in the human diet. Although species, trophic level, and means of production are typically considered in predicting fish pollutant load, and thus recommendations of consumption, capture location is usuall …
BACKGROUND: Fish are a source of persistent organic pollutants (POPs) in the human diet. Although species, trophic level, and means o …
Migration of sea urchin primordial germ cells.
Campanale JP, Gökirmak T, Espinoza JA, Oulhen N, Wessel GM, Hamdoun A. Campanale JP, et al. Dev Dyn. 2014 Jul;243(7):917-27. doi: 10.1002/dvdy.24133. Epub 2014 Apr 30. Dev Dyn. 2014. PMID: 24677545 Free PMC article.
By 54 HPF, they begin moving in the plane of the blastoderm, often in a directed fashion, towards the coelomic pouches. Isolated small micromeres also produced blebs and filopodia. ...
By 54 HPF, they begin moving in the plane of the blastoderm, often in a directed fashion, towards the coelomic pouches. Isolated smal …
Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos.
Gökirmak T, Shipp LE, Campanale JP, Nicklisch SC, Hamdoun A. Gökirmak T, et al. Mol Reprod Dev. 2014 Sep;81(9):778-93. doi: 10.1002/mrd.22357. Epub 2014 Aug 22. Mol Reprod Dev. 2014. PMID: 25156004 Free PMC article. Review.
Functional diversification of sea urchin ABCC1 (MRP1) by alternative splicing.
Gökirmak T, Campanale JP, Reitzel AM, Shipp LE, Moy GW, Hamdoun A. Gökirmak T, et al. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C911-20. doi: 10.1152/ajpcell.00029.2016. Epub 2016 Apr 6. Am J Physiol Cell Physiol. 2016. PMID: 27053522 Free PMC article.
The multidrug resistance protein (MRP) family encodes a diverse repertoire of ATP-binding cassette (ABC) transporters with multiple roles in development, disease, and homeostasis. ...Phylogenetic comparisons also indicate that while MRP1, MRP3, and MRP6 transporters potent …
The multidrug resistance protein (MRP) family encodes a diverse repertoire of ATP-binding cassette (ABC) transporters with multiple r …
Programmed reduction of ABC transporter activity in sea urchin germline progenitors.
Campanale JP, Hamdoun A. Campanale JP, et al. Development. 2012 Feb;139(4):783-92. doi: 10.1242/dev.076752. Development. 2012. PMID: 22274698 Free PMC article.
Unexpectedly, we found small micromeres accumulate 2.32 times more of the ABC transporter substrates calcein-AM, CellTrace RedOrange, BoDipy-verapamil and BoDipy-vinblastine, than any other cell in the embryo, indicating a reduction in multidrug efflux activity. The reduct …
Unexpectedly, we found small micromeres accumulate 2.32 times more of the ABC transporter substrates calcein-AM, CellTrace RedOrange, BoDipy …
Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli.
Whalen K, Reitzel AM, Hamdoun A. Whalen K, et al. Mol Biol Cell. 2012 Sep;23(18):3663-72. doi: 10.1091/mbc.E12-06-0438. Epub 2012 Aug 1. Mol Biol Cell. 2012. PMID: 22855533 Free PMC article.
In sea urchins, these changes include polymerization of cortical actin and a coincident, switch-like increase in the activity of the multidrug efflux transporter ABCB1a. ...Finally, interference with Rab11, a regulator of apical recycling, inhibits activation of eff …
In sea urchins, these changes include polymerization of cortical actin and a coincident, switch-like increase in the activity of the …
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