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Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B.
Hamel E. Hamel E. Pharmacol Ther. 1992;55(1):31-51. doi: 10.1016/0163-7258(92)90028-x. Pharmacol Ther. 1992. PMID: 1287674 Review.
Tubulin-dependent hydrolysis of guanosine triphosphate as a screening test to identify new antitubulin compounds with potential as antimitotic agents: application to carbamates of aromatic amines.
Chi DM, Shahrik LK, Ho HH, Hamel E. Chi DM, et al. Among authors: hamel e. Cancer Res. 1989 Mar 15;49(6):1344-8. Cancer Res. 1989. PMID: 2924291
There were no false negatives (i.e., no agent inactive in the GTPase assay inhibited tubulin polymerization). The true positives were examined for effects on cell growth and mitosis, and four compounds had 50% inhibitory concentration values of 2 microM or less with L1210 …
There were no false negatives (i.e., no agent inactive in the GTPase assay inhibited tubulin polymerization). The true positives were …
Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1.
Bai R, Durso NA, Sackett DL, Hamel E. Bai R, et al. Among authors: hamel e. Biochemistry. 1999 Oct 26;38(43):14302-10. doi: 10.1021/bi991323e. Biochemistry. 1999. PMID: 10572005
The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.
Hamel E, Sackett DL, Vourloumis D, Nicolaou KC. Hamel E, et al. Biochemistry. 1999 Apr 27;38(17):5490-8. doi: 10.1021/bi983023n. Biochemistry. 1999. PMID: 10220336
We examined interactions with purified tubulin of synthetic sarcodictyins A and B and eleutherobin (coral-derived antimitotic agents) and of compound 1, an analogue of sarcodictyin A methylated at the C-3 oxygen atom (i.e., the methyl ketal analogue of sarcodictyin A and t …
We examined interactions with purified tubulin of synthetic sarcodictyins A and B and eleutherobin (coral-derived antimitotic agents) and of …
Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers.
Hamel E, Lin CM, Flynn E, D'Amato RJ. Hamel E, et al. Biochemistry. 1996 Jan 30;35(4):1304-10. doi: 10.1021/bi951559s. Biochemistry. 1996. PMID: 8573587
Derivatives of 5,6-diphenylpyridazin-3-one: synthetic antimitotic agents which interact with plant and mammalian tubulin at a new drug-binding site.
Batra JK, Powers LJ, Hess FD, Hamel E. Batra JK, et al. Among authors: hamel e. Cancer Res. 1986 Apr;46(4 Pt 2):1889-93. Cancer Res. 1986. PMID: 3948171
Partial synthesis and antitubulin activity of minor colchicum alkaloids: N-acetoacetyl-deacetylcolchicine and 2-demethylspeciosine (speciocolchine).
Muzaffar A, Brossi A, Hamel E. Muzaffar A, et al. Among authors: hamel e. J Nat Prod. 1990 Jul-Aug;53(4):1021-4. doi: 10.1021/np50070a044. J Nat Prod. 1990. PMID: 2095370
Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin.
Hamel E, Lin CM, Plowman J, Wang HK, Lee KH, Paull KD. Hamel E, et al. Biochem Pharmacol. 1996 Jan 12;51(1):53-9. doi: 10.1016/0006-2952(95)02156-6. Biochem Pharmacol. 1996. PMID: 8534268
Binding of maytansine to tubulin: competition with other mitotic inhibitors.
Lin CM, Hamel E, Wolpert-DeFilippes MK. Lin CM, et al. Among authors: hamel e. Res Commun Chem Pathol Pharmacol. 1981 Mar;31(3):443-51. Res Commun Chem Pathol Pharmacol. 1981. PMID: 7255878
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
Kowalski RJ, Giannakakou P, Gunasekera SP, Longley RE, Day BW, Hamel E. Kowalski RJ, et al. Among authors: hamel e. Mol Pharmacol. 1997 Oct;52(4):613-22. Mol Pharmacol. 1997. PMID: 9380024
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