Hamel E - Search Results

1

Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

Bai RL, Lin CM, Nguyen NY, Liu TY, Hamel E. Bai RL, et al. Among authors: hamel e. Biochemistry. 1989 Jun 27;28(13):5606-12. doi: 10.1021/bi00439a040. Biochemistry. 1989. PMID: 2775724

Shown in previous studies to inhibit tubulin polymerization [Abraham, I., Dion, R. L., Duanmu, C., Gottesman, M. M., & Hamel, E. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 6839-6843] and to form a covalent bond preferentially with beta-tubulin [Bai, R., Duanmu, C. …

Shown in previous studies to inhibit tubulin polymerization [Abraham, I., Dion, R. L., Duanmu, C., Gottesman, M. M., & Hamel, …

2

Tubulin-dependent hydrolysis of guanosine triphosphate as a screening test to identify new antitubulin compounds with potential as antimitotic agents: application to carbamates of aromatic amines.

Chi DM, Shahrik LK, Ho HH, Hamel E. Chi DM, et al. Among authors: hamel e. Cancer Res. 1989 Mar 15;49(6):1344-8. Cancer Res. 1989. PMID: 2924291

3

Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1.

Bai R, Durso NA, Sackett DL, Hamel E. Bai R, et al. Among authors: hamel e. Biochemistry. 1999 Oct 26;38(43):14302-10. doi: 10.1021/bi991323e. Biochemistry. 1999. PMID: 10572005

4

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

Hamel E, Sackett DL, Vourloumis D, Nicolaou KC. Hamel E, et al. Biochemistry. 1999 Apr 27;38(17):5490-8. doi: 10.1021/bi983023n. Biochemistry. 1999. PMID: 10220336

5

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

ter Haar E, Kowalski RJ, Hamel E, Lin CM, Longley RE, Gunasekera SP, Rosenkranz HS, Day BW. ter Haar E, et al. Among authors: hamel e. Biochemistry. 1996 Jan 9;35(1):243-50. doi: 10.1021/bi9515127. Biochemistry. 1996. PMID: 8555181

6

Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers.

Hamel E, Lin CM, Flynn E, D'Amato RJ. Hamel E, et al. Biochemistry. 1996 Jan 30;35(4):1304-10. doi: 10.1021/bi951559s. Biochemistry. 1996. PMID: 8573587

7

2,4-Dichlorobenzyl thiocyanate, an antimitotic agent that alters microtubule morphology.

Abraham I, Dion RL, Chi DM, Gottesman MM, Hamel E. Abraham I, et al. Among authors: hamel e. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6839-43. doi: 10.1073/pnas.83.18.6839. Proc Natl Acad Sci U S A. 1986. PMID: 3462730 Free PMC article.

8

Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.

Verdier-Pinard P, Sitachitta N, Rossi JV, Sackett DL, Gerwick WH, Hamel E. Verdier-Pinard P, et al. Among authors: hamel e. Arch Biochem Biophys. 1999 Oct 1;370(1):51-8. doi: 10.1006/abbi.1999.1363. Arch Biochem Biophys. 1999. PMID: 10496976

9

Partial synthesis and antitubulin activity of minor colchicum alkaloids: N-acetoacetyl-deacetylcolchicine and 2-demethylspeciosine (speciocolchine).

Muzaffar A, Brossi A, Hamel E. Muzaffar A, et al. Among authors: hamel e. J Nat Prod. 1990 Jul-Aug;53(4):1021-4. doi: 10.1021/np50070a044. J Nat Prod. 1990. PMID: 2095370

10

N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties.

Kang GJ, Getahun Z, Muzaffar A, Brossi A, Hamel E. Kang GJ, et al. Among authors: hamel e. J Biol Chem. 1990 Jun 25;265(18):10255-9. J Biol Chem. 1990. PMID: 2191947

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