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Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations?
Hammarlund-Udenaes M. Hammarlund-Udenaes M. Basic Clin Pharmacol Toxicol. 2010 Mar;106(3):215-20. doi: 10.1111/j.1742-7843.2009.00517.x. Epub 2009 Dec 30. Basic Clin Pharmacol Toxicol. 2010. PMID: 20050843 Review.
The postoperative pharmacokinetics of codeine.
Persson K, Hammarlund-Udenaes M, Mortimer O, Rane A. Persson K, et al. Eur J Clin Pharmacol. 1992;42(6):663-6. doi: 10.1007/BF00265933. Eur J Clin Pharmacol. 1992. PMID: 1623909
Estimation of unbound concentrations of morphine from microdialysate concentrations by use of nonlinear regression analysis in vivo and in vitro during steady state conditions.
Ekblom M, Gårdmark M, Hammarlund-Udenaes M. Ekblom M, et al. Life Sci. 1992;51(6):449-60. doi: 10.1016/0024-3205(92)90413-j. Life Sci. 1992. PMID: 1635423
Remoxipride: pharmacokinetics and effect on plasma prolactin.
Movin-Osswald G, Hammarlund-Udenaes M. Movin-Osswald G, et al. Br J Clin Pharmacol. 1991 Sep;32(3):355-60. doi: 10.1111/j.1365-2125.1991.tb03911.x. Br J Clin Pharmacol. 1991. PMID: 1685665 Free PMC article. Clinical Trial.
Studies of meclofenamic acid and two metabolites in horses--pharmacokinetics and effects on exercise tolerance.
Johansson IM, Kallings P, Hammarlund-Udenaes M. Johansson IM, et al. J Vet Pharmacol Ther. 1991 Sep;14(3):235-42. doi: 10.1111/j.1365-2885.1991.tb00832.x. J Vet Pharmacol Ther. 1991. PMID: 1744932
Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan.
Persson K, Sjöström S, Sigurdardottir I, Molnár V, Hammarlund-Udenaes M, Rane A. Persson K, et al. Br J Clin Pharmacol. 1995 Feb;39(2):182-6. doi: 10.1111/j.1365-2125.1995.tb04428.x. Br J Clin Pharmacol. 1995. PMID: 7742159 Free PMC article.
Quantification of effect delay and acute tolerance development to morphine in the rat.
Gårdmark M, Ekblom M, Bouw R, Hammarlund-Udenaes M. Gårdmark M, et al. J Pharmacol Exp Ther. 1993 Dec;267(3):1061-7. J Pharmacol Exp Ther. 1993. PMID: 8263765
The pharmacokinetics of remoxipride and metabolites in patients with various degrees of renal function.
Movin-Osswald G, Boelaert J, Hammarlund-Udenaes M, Nilsson LB. Movin-Osswald G, et al. Br J Clin Pharmacol. 1993 Jun;35(6):615-22. doi: 10.1111/j.1365-2125.1993.tb04191.x. Br J Clin Pharmacol. 1993. PMID: 8329289 Free PMC article.
Modeling of tolerance development and rebound effect during different intravenous administrations of morphine to rats.
Ekblom M, Hammarlund-Udenaes M, Paalzow L. Ekblom M, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):244-52. J Pharmacol Exp Ther. 1993. PMID: 8331561
Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method.
Hammarlund-Udenaes M, Paalzow LK, de Lange EC. Hammarlund-Udenaes M, et al. Pharm Res. 1997 Feb;14(2):128-34. doi: 10.1023/a:1012080106490. Pharm Res. 1997. PMID: 9090698
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